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Cancer of unknown primary is associated with diabetes.

Hemminki, Kari LU ; Försti, Asta LU ; Sundquist, Kristina LU and Li, Xinjun LU (2016) In European Journal of Cancer Prevention 25(3). p.246-251
Abstract
The incidences of both type 1 diabetes (T1D) and T2D are increasing worldwide. T2D is associated with many cancers. However, no data are available on cancer of unknown primary (CUP), a relatively common, fatal cancer for which tobacco smoking is the only known risk factor. At diagnosis, CUP metastases are found in various organs, which has implications for prognosis. We carried out a nationwide study on the association of CUP with T1D and T2D. 32 600 T1D patients and 178 000 T2D patients were identified from the national healthcare registers and these were linked to the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP from 1997 through 2010 using anyone without diabetes as a reference. The SIR of CUP in... (More)
The incidences of both type 1 diabetes (T1D) and T2D are increasing worldwide. T2D is associated with many cancers. However, no data are available on cancer of unknown primary (CUP), a relatively common, fatal cancer for which tobacco smoking is the only known risk factor. At diagnosis, CUP metastases are found in various organs, which has implications for prognosis. We carried out a nationwide study on the association of CUP with T1D and T2D. 32 600 T1D patients and 178 000 T2D patients were identified from the national healthcare registers and these were linked to the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP from 1997 through 2010 using anyone without diabetes as a reference. The SIR of CUP in 421 diabetic patients was 1.71, highest for CUP with liver (2.17) and respiratory system (1.95) metastases. The SIR was 2.91 for T1D, but with a small number of patients, 1.38 for T2D with insulin treatment, and 1.78 for the main group of T2D. CUP with liver and respiratory system metastases increased for each diabetic type; however, for T2D, CUP with gastrointestinal and bone metastases also increased. The results provide the first demonstration that CUP is one of the cancers associated with diabetes, with definite evidence on T2D. CUP has a poor prognosis, which may be even worse when diabetes is the underlying comorbidity. A mechanistic question for future work is to determine whether diabetes promotes primaries that escape detection or their metastatic spread. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer Prevention
volume
25
issue
3
pages
246 - 251
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:26011105
  • scopus:84962124102
  • wos:000374759100011
ISSN
1473-5709
DOI
10.1097/CEJ.0000000000000165
language
English
LU publication?
yes
id
0f4d7093-26f1-4226-820a-d52f5069e0c5 (old id 5442222)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26011105?dopt=Abstract
date added to LUP
2015-06-05 15:14:23
date last changed
2017-04-09 04:28:11
@article{0f4d7093-26f1-4226-820a-d52f5069e0c5,
  abstract     = {The incidences of both type 1 diabetes (T1D) and T2D are increasing worldwide. T2D is associated with many cancers. However, no data are available on cancer of unknown primary (CUP), a relatively common, fatal cancer for which tobacco smoking is the only known risk factor. At diagnosis, CUP metastases are found in various organs, which has implications for prognosis. We carried out a nationwide study on the association of CUP with T1D and T2D. 32 600 T1D patients and 178 000 T2D patients were identified from the national healthcare registers and these were linked to the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP from 1997 through 2010 using anyone without diabetes as a reference. The SIR of CUP in 421 diabetic patients was 1.71, highest for CUP with liver (2.17) and respiratory system (1.95) metastases. The SIR was 2.91 for T1D, but with a small number of patients, 1.38 for T2D with insulin treatment, and 1.78 for the main group of T2D. CUP with liver and respiratory system metastases increased for each diabetic type; however, for T2D, CUP with gastrointestinal and bone metastases also increased. The results provide the first demonstration that CUP is one of the cancers associated with diabetes, with definite evidence on T2D. CUP has a poor prognosis, which may be even worse when diabetes is the underlying comorbidity. A mechanistic question for future work is to determine whether diabetes promotes primaries that escape detection or their metastatic spread.},
  author       = {Hemminki, Kari and Försti, Asta and Sundquist, Kristina and Li, Xinjun},
  issn         = {1473-5709},
  language     = {eng},
  number       = {3},
  pages        = {246--251},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cancer Prevention},
  title        = {Cancer of unknown primary is associated with diabetes.},
  url          = {http://dx.doi.org/10.1097/CEJ.0000000000000165},
  volume       = {25},
  year         = {2016},
}