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HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.

Hadley, David; Hagopian, William; Liu, Edwin; She, Jin-Xiong; Simell, Olli; Akolkar, Beena; Ziegler, Anette-G; Rewers, Marian; Krischer, Jeffrey P and Chen, Wei-Min, et al. (2015) In American Journal of Gastroenterology 110(6). p.915-920
Abstract
Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.
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publication status
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American Journal of Gastroenterology
volume
110
issue
6
pages
915 - 920
publisher
Wiley-Blackwell
external identifiers
  • pmid:26010309
  • wos:000357081800021
  • scopus:84930757675
ISSN
1572-0241
DOI
10.1038/ajg.2015.150
language
English
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yes
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c5986bd0-fc7e-43d1-9965-955105472205 (old id 5442297)
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http://www.ncbi.nlm.nih.gov/pubmed/26010309?dopt=Abstract
date added to LUP
2015-06-05 13:37:57
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2017-07-30 03:19:42
@article{c5986bd0-fc7e-43d1-9965-955105472205,
  abstract     = {Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.},
  author       = {Hadley, David and Hagopian, William and Liu, Edwin and She, Jin-Xiong and Simell, Olli and Akolkar, Beena and Ziegler, Anette-G and Rewers, Marian and Krischer, Jeffrey P and Chen, Wei-Min and Onengut-Gumuscu, Suna and Bugawan, Teodorica L and Rich, Stephen S and Erlich, Henry and Agardh, Daniel},
  issn         = {1572-0241},
  language     = {eng},
  number       = {6},
  pages        = {915--920},
  publisher    = {Wiley-Blackwell},
  series       = {American Journal of Gastroenterology},
  title        = {HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.},
  url          = {http://dx.doi.org/10.1038/ajg.2015.150},
  volume       = {110},
  year         = {2015},
}