Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.

Hadley, David ; Hagopian, William ; Liu, Edwin ; She, Jin-Xiong ; Simell, Olli ; Akolkar, Beena ; Ziegler, Anette-G ; Rewers, Marian ; Krischer, Jeffrey P and Chen, Wei-Min , et al. (2015) In American Journal of Gastroenterology 110(6). p.915-920
Abstract
Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Gastroenterology
volume
110
issue
6
pages
915 - 920
publisher
Wolters Kluwer
external identifiers
  • pmid:26010309
  • wos:000357081800021
  • scopus:84930757675
  • pmid:26010309
ISSN
1572-0241
DOI
10.1038/ajg.2015.150
language
English
LU publication?
yes
id
c5986bd0-fc7e-43d1-9965-955105472205 (old id 5442297)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26010309?dopt=Abstract
date added to LUP
2016-04-01 10:42:00
date last changed
2022-01-26 01:41:25
@article{c5986bd0-fc7e-43d1-9965-955105472205,
  abstract     = {{Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.}},
  author       = {{Hadley, David and Hagopian, William and Liu, Edwin and She, Jin-Xiong and Simell, Olli and Akolkar, Beena and Ziegler, Anette-G and Rewers, Marian and Krischer, Jeffrey P and Chen, Wei-Min and Onengut-Gumuscu, Suna and Bugawan, Teodorica L and Rich, Stephen S and Erlich, Henry and Agardh, Daniel}},
  issn         = {{1572-0241}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{915--920}},
  publisher    = {{Wolters Kluwer}},
  series       = {{American Journal of Gastroenterology}},
  title        = {{HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.}},
  url          = {{http://dx.doi.org/10.1038/ajg.2015.150}},
  doi          = {{10.1038/ajg.2015.150}},
  volume       = {{110}},
  year         = {{2015}},
}