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Cortical burst dynamics predict clinical outcome early in extremely preterm infants.

Iyer, Kartik K; Roberts, James A; Hellström-Westas, Lena LU ; Wikström, Sverre; Pupp, Ingrid LU ; Ley, David LU ; Vanhatalo, Sampsa and Breakspear, Michael (2015) In Brain 138(May 22). p.2206-2218
Abstract
Intermittent bursts of electrical activity are a ubiquitous signature of very early brain activity. Previous studies have largely focused on assessing the amplitudes of these transient cortical bursts or the intervals between them. Recent advances in basic neuroscience have identified the presence of scale-free 'avalanche' processes in bursting patterns of cortical activity in other clinical contexts. Here, we hypothesize that cortical bursts in human preterm infants also exhibit scale-free properties, providing new insights into the nature, temporal evolution, and prognostic value of spontaneous brain activity in the days immediately following preterm birth. We examined electroencephalographic recordings from 43 extremely preterm infants... (More)
Intermittent bursts of electrical activity are a ubiquitous signature of very early brain activity. Previous studies have largely focused on assessing the amplitudes of these transient cortical bursts or the intervals between them. Recent advances in basic neuroscience have identified the presence of scale-free 'avalanche' processes in bursting patterns of cortical activity in other clinical contexts. Here, we hypothesize that cortical bursts in human preterm infants also exhibit scale-free properties, providing new insights into the nature, temporal evolution, and prognostic value of spontaneous brain activity in the days immediately following preterm birth. We examined electroencephalographic recordings from 43 extremely preterm infants (gestational age 22-28 weeks) and demonstrated that their cortical bursts exhibit scale-free properties as early as 12 h after birth. The scaling relationships of cortical bursts correlate significantly with later mental development-particularly within the first 12 h of life. These findings show that early preterm brain activity is characterized by scale-free dynamics which carry developmental significance, hence offering novel means for rapid and early clinical prediction of neurodevelopmental outcomes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Brain
volume
138
issue
May 22
pages
2206 - 2218
publisher
Oxford University Press
external identifiers
  • pmid:26001723
  • wos:000360578700019
  • scopus:84938247186
ISSN
1460-2156
DOI
10.1093/brain/awv129
language
English
LU publication?
yes
id
0de02b69-8df6-4281-bac4-64ff4e6aa9c4 (old id 5442585)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26001723?dopt=Abstract
date added to LUP
2015-06-05 12:25:34
date last changed
2017-11-19 03:03:51
@article{0de02b69-8df6-4281-bac4-64ff4e6aa9c4,
  abstract     = {Intermittent bursts of electrical activity are a ubiquitous signature of very early brain activity. Previous studies have largely focused on assessing the amplitudes of these transient cortical bursts or the intervals between them. Recent advances in basic neuroscience have identified the presence of scale-free 'avalanche' processes in bursting patterns of cortical activity in other clinical contexts. Here, we hypothesize that cortical bursts in human preterm infants also exhibit scale-free properties, providing new insights into the nature, temporal evolution, and prognostic value of spontaneous brain activity in the days immediately following preterm birth. We examined electroencephalographic recordings from 43 extremely preterm infants (gestational age 22-28 weeks) and demonstrated that their cortical bursts exhibit scale-free properties as early as 12 h after birth. The scaling relationships of cortical bursts correlate significantly with later mental development-particularly within the first 12 h of life. These findings show that early preterm brain activity is characterized by scale-free dynamics which carry developmental significance, hence offering novel means for rapid and early clinical prediction of neurodevelopmental outcomes.},
  author       = {Iyer, Kartik K and Roberts, James A and Hellström-Westas, Lena and Wikström, Sverre and Pupp, Ingrid and Ley, David and Vanhatalo, Sampsa and Breakspear, Michael},
  issn         = {1460-2156},
  language     = {eng},
  number       = {May 22},
  pages        = {2206--2218},
  publisher    = {Oxford University Press},
  series       = {Brain},
  title        = {Cortical burst dynamics predict clinical outcome early in extremely preterm infants.},
  url          = {http://dx.doi.org/10.1093/brain/awv129},
  volume       = {138},
  year         = {2015},
}