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Long-term retention of 177Lu/177mLu-Dotatate in patients investigated by gamma spectrometry and gamma camera imaging.

Sjögreen Gleisner, Katarina LU ; Brolin, Gustav LU ; Sundlöv, Anna LU ; Mjekiqi, Edita; Östlund, Karl LU ; Tennvall, Jan LU and Larsson, Erik LU (2015) In Journal of Nuclear Medicine 56(7). p.976-984
Abstract
Dosimetry in peptide receptor radionuclide therapy using (177)Lu-Dotatate is based on patient imaging during the first week after administration, and determination of the activity retention as a function of time for different tissues. For calculation of the absorbed dose it is generally assumed that the long-term activity retention follows the pattern determined from the first week. This work aims to investigate the validity of this assumption by performing additional patient measurements between 5 and 10 weeks after administration. A further aim is to investigate to what extent absorbed dose values are affected when including these measurements, also taking into account the radionuclide impurity of (177)mLu and build-up of secondary... (More)
Dosimetry in peptide receptor radionuclide therapy using (177)Lu-Dotatate is based on patient imaging during the first week after administration, and determination of the activity retention as a function of time for different tissues. For calculation of the absorbed dose it is generally assumed that the long-term activity retention follows the pattern determined from the first week. This work aims to investigate the validity of this assumption by performing additional patient measurements between 5 and 10 weeks after administration. A further aim is to investigate to what extent absorbed dose values are affected when including these measurements, also taking into account the radionuclide impurity of (177)mLu and build-up of secondary (177)Lu from the (177)mLu decay. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
56
issue
7
pages
976 - 984
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:25999429
  • wos:000357754600025
  • scopus:84936747451
ISSN
0161-5505
DOI
10.2967/jnumed.115.155390
language
English
LU publication?
yes
id
e79e46ef-8538-41d0-b251-12131da6704a (old id 5442650)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25999429?dopt=Abstract
date added to LUP
2015-06-05 12:11:21
date last changed
2017-03-12 03:09:53
@article{e79e46ef-8538-41d0-b251-12131da6704a,
  abstract     = {Dosimetry in peptide receptor radionuclide therapy using (177)Lu-Dotatate is based on patient imaging during the first week after administration, and determination of the activity retention as a function of time for different tissues. For calculation of the absorbed dose it is generally assumed that the long-term activity retention follows the pattern determined from the first week. This work aims to investigate the validity of this assumption by performing additional patient measurements between 5 and 10 weeks after administration. A further aim is to investigate to what extent absorbed dose values are affected when including these measurements, also taking into account the radionuclide impurity of (177)mLu and build-up of secondary (177)Lu from the (177)mLu decay.},
  author       = {Sjögreen Gleisner, Katarina and Brolin, Gustav and Sundlöv, Anna and Mjekiqi, Edita and Östlund, Karl and Tennvall, Jan and Larsson, Erik},
  issn         = {0161-5505},
  language     = {eng},
  number       = {7},
  pages        = {976--984},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {Long-term retention of 177Lu/177mLu-Dotatate in patients investigated by gamma spectrometry and gamma camera imaging.},
  url          = {http://dx.doi.org/10.2967/jnumed.115.155390},
  volume       = {56},
  year         = {2015},
}