Long-term retention of 177Lu/177mLu-Dotatate in patients investigated by gamma spectrometry and gamma camera imaging.
(2015) In Journal of Nuclear Medicine 56(7). p.976-984- Abstract
- Dosimetry in peptide receptor radionuclide therapy using (177)Lu-Dotatate is based on patient imaging during the first week after administration, and determination of the activity retention as a function of time for different tissues. For calculation of the absorbed dose it is generally assumed that the long-term activity retention follows the pattern determined from the first week. This work aims to investigate the validity of this assumption by performing additional patient measurements between 5 and 10 weeks after administration. A further aim is to investigate to what extent absorbed dose values are affected when including these measurements, also taking into account the radionuclide impurity of (177)mLu and build-up of secondary... (More)
- Dosimetry in peptide receptor radionuclide therapy using (177)Lu-Dotatate is based on patient imaging during the first week after administration, and determination of the activity retention as a function of time for different tissues. For calculation of the absorbed dose it is generally assumed that the long-term activity retention follows the pattern determined from the first week. This work aims to investigate the validity of this assumption by performing additional patient measurements between 5 and 10 weeks after administration. A further aim is to investigate to what extent absorbed dose values are affected when including these measurements, also taking into account the radionuclide impurity of (177)mLu and build-up of secondary (177)Lu from the (177)mLu decay. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5442650
- author
- Sjögreen Gleisner, Katarina LU ; Brolin, Gustav LU ; Sundlöv, Anna LU ; Mjekiqi, Edita ; Östlund, Karl LU ; Tennvall, Jan LU and Larsson, Erik LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Nuclear Medicine
- volume
- 56
- issue
- 7
- pages
- 976 - 984
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- pmid:25999429
- wos:000357754600025
- scopus:84936747451
- pmid:25999429
- ISSN
- 0161-5505
- DOI
- 10.2967/jnumed.115.155390
- language
- English
- LU publication?
- yes
- id
- e79e46ef-8538-41d0-b251-12131da6704a (old id 5442650)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25999429?dopt=Abstract
- date added to LUP
- 2016-04-01 10:26:28
- date last changed
- 2022-04-04 18:02:42
@article{e79e46ef-8538-41d0-b251-12131da6704a, abstract = {{Dosimetry in peptide receptor radionuclide therapy using (177)Lu-Dotatate is based on patient imaging during the first week after administration, and determination of the activity retention as a function of time for different tissues. For calculation of the absorbed dose it is generally assumed that the long-term activity retention follows the pattern determined from the first week. This work aims to investigate the validity of this assumption by performing additional patient measurements between 5 and 10 weeks after administration. A further aim is to investigate to what extent absorbed dose values are affected when including these measurements, also taking into account the radionuclide impurity of (177)mLu and build-up of secondary (177)Lu from the (177)mLu decay.}}, author = {{Sjögreen Gleisner, Katarina and Brolin, Gustav and Sundlöv, Anna and Mjekiqi, Edita and Östlund, Karl and Tennvall, Jan and Larsson, Erik}}, issn = {{0161-5505}}, language = {{eng}}, number = {{7}}, pages = {{976--984}}, publisher = {{Society of Nuclear Medicine}}, series = {{Journal of Nuclear Medicine}}, title = {{Long-term retention of 177Lu/177mLu-Dotatate in patients investigated by gamma spectrometry and gamma camera imaging.}}, url = {{http://dx.doi.org/10.2967/jnumed.115.155390}}, doi = {{10.2967/jnumed.115.155390}}, volume = {{56}}, year = {{2015}}, }