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Men With Late Effects of Polio Decline More Than Women in Lower Limb Muscle Strength: A 4-Year Longitudinal Study.

Flansbjer, Ulla-Britt LU ; Brogårdh, Christina LU ; Horstmann, Vibeke LU and Lexell, Jan LU (2015) In PM&R 7(11). p.1127-1136
Abstract
In persons with prior paralytic poliomyelitis, progressive muscle weakness can occur after a stable period of at least 15 years. Knowledge is limited about which factors influence changes in lower limb muscle strength in these persons. Objective. To assess changes in lower limb muscle strength annually over 4 years in persons with late effects of polio and to identify prognostic factors for changes in muscle strength. A prospective, longitudinal study. University hospital outpatient program. Fifty-two ambulant persons (mean age ± standard deviation: 64 ± 6 years) with verified late effects of polio.

Mixed linear models were used to analyze changes in muscle strength and to identify determinants among the following covariates:... (More)
In persons with prior paralytic poliomyelitis, progressive muscle weakness can occur after a stable period of at least 15 years. Knowledge is limited about which factors influence changes in lower limb muscle strength in these persons. Objective. To assess changes in lower limb muscle strength annually over 4 years in persons with late effects of polio and to identify prognostic factors for changes in muscle strength. A prospective, longitudinal study. University hospital outpatient program. Fifty-two ambulant persons (mean age ± standard deviation: 64 ± 6 years) with verified late effects of polio.

Mixed linear models were used to analyze changes in muscle strength and to identify determinants among the following covariates: gender, age, age at acute polio infection, time with late effects of polio, body mass index, and estimated baseline muscle weakness.

Knee extensor and flexor and ankle dorsiflexor muscle strength were measured annually with a Biodex dynamometer.

The men (n = 28) had significant linear change over time for all knee muscle strength measurements, from −1.4% (P < .05) per year for isokinetic knee flexion in the less-affected lower limb to −4.2% (P < .001) for isokinetic knee extension in the more-affected lower limb, and for 2 ankle dorsiflexor muscle strength measurements (−3.3%-1.4% per year [P < .05]). The women (n = 24) had a significant linear change over time only for ankle dorsiflexor measurements (4.0%-5.5% per year [P < .01]). Gender was the strongest factor that predicted a change in muscle strength over time.Over 4 years, men had a greater decline in muscle strength than did women, but the rate of decline did not accelerate. This finding indicates that gender could be a contributing factor to the progressive decline in muscle strength in persons with late effects of polio. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PM&R
volume
7
issue
11
pages
1127 - 1136
publisher
Elsevier
external identifiers
  • pmid:25978946
  • wos:000365074300003
  • scopus:84947865787
ISSN
1934-1563
DOI
10.1016/j.pmrj.2015.05.005
language
English
LU publication?
yes
id
f11e8cf7-60da-4cd1-a73f-e4f877cd8482 (old id 5453155)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25978946?dopt=Abstract
date added to LUP
2015-06-04 20:35:48
date last changed
2017-10-29 03:01:05
@article{f11e8cf7-60da-4cd1-a73f-e4f877cd8482,
  abstract     = {In persons with prior paralytic poliomyelitis, progressive muscle weakness can occur after a stable period of at least 15 years. Knowledge is limited about which factors influence changes in lower limb muscle strength in these persons. Objective. To assess changes in lower limb muscle strength annually over 4 years in persons with late effects of polio and to identify prognostic factors for changes in muscle strength. A prospective, longitudinal study. University hospital outpatient program. Fifty-two ambulant persons (mean age ± standard deviation: 64 ± 6 years) with verified late effects of polio.<br/><br>
Mixed linear models were used to analyze changes in muscle strength and to identify determinants among the following covariates: gender, age, age at acute polio infection, time with late effects of polio, body mass index, and estimated baseline muscle weakness.<br/><br>
Knee extensor and flexor and ankle dorsiflexor muscle strength were measured annually with a Biodex dynamometer.<br/><br>
The men (n = 28) had significant linear change over time for all knee muscle strength measurements, from −1.4% (P &lt; .05) per year for isokinetic knee flexion in the less-affected lower limb to −4.2% (P &lt; .001) for isokinetic knee extension in the more-affected lower limb, and for 2 ankle dorsiflexor muscle strength measurements (−3.3%-1.4% per year [P &lt; .05]). The women (n = 24) had a significant linear change over time only for ankle dorsiflexor measurements (4.0%-5.5% per year [P &lt; .01]). Gender was the strongest factor that predicted a change in muscle strength over time.Over 4 years, men had a greater decline in muscle strength than did women, but the rate of decline did not accelerate. This finding indicates that gender could be a contributing factor to the progressive decline in muscle strength in persons with late effects of polio.},
  author       = {Flansbjer, Ulla-Britt and Brogårdh, Christina and Horstmann, Vibeke and Lexell, Jan},
  issn         = {1934-1563},
  language     = {eng},
  number       = {11},
  pages        = {1127--1136},
  publisher    = {Elsevier},
  series       = {PM&R},
  title        = {Men With Late Effects of Polio Decline More Than Women in Lower Limb Muscle Strength: A 4-Year Longitudinal Study.},
  url          = {http://dx.doi.org/10.1016/j.pmrj.2015.05.005},
  volume       = {7},
  year         = {2015},
}