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Clinically meaningful parameters of progression and long-term outcome of Parkinson disease: An international consensus statement.

Puschmann, Andreas LU ; Brighina, Laura; Markopoulou, Katerina; Aasly, Jan; Chung, Sun Ju; Frigerio, Roberta; Hadjigeorgiou, Georgios; Kõks, Sulev; Krüger, Rejko and Siuda, Joanna, et al. (2015) In Parkinsonism & Related Disorders 21(7). p.675-682
Abstract
Parkinson disease (PD) is associated with a clinical course of variable duration, severity, and a combination of motor and non-motor features. Recent PD research has focused primarily on etiology rather than clinical progression and long-term outcomes. For the PD patient, caregivers, and clinicians, information on expected clinical progression and long-term outcomes is of great importance. Today, it remains largely unknown what factors influence long-term clinical progression and outcomes in PD; recent data indicate that the factors that increase the risk to develop PD differ, at least partly, from those that accelerate clinical progression and lead to worse outcomes. Prospective studies will be required to identify factors that influence... (More)
Parkinson disease (PD) is associated with a clinical course of variable duration, severity, and a combination of motor and non-motor features. Recent PD research has focused primarily on etiology rather than clinical progression and long-term outcomes. For the PD patient, caregivers, and clinicians, information on expected clinical progression and long-term outcomes is of great importance. Today, it remains largely unknown what factors influence long-term clinical progression and outcomes in PD; recent data indicate that the factors that increase the risk to develop PD differ, at least partly, from those that accelerate clinical progression and lead to worse outcomes. Prospective studies will be required to identify factors that influence progression and outcome. We suggest that data for such studies is collected during routine office visits in order to guarantee high external validity of such research. We report here the results of a consensus meeting of international movement disorder experts from the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium, who convened to define which long-term outcomes are of interest to patients, caregivers and clinicians, and what is presently known about environmental or genetic factors influencing clinical progression or long-term outcomes in PD. We propose a panel of rating scales that collects a significant amount of phenotypic information, can be performed in the routine office visit and allows international standardization. Research into the progression and long-term outcomes of PD aims at providing individual prognostic information early, adapting treatment choices, and taking specific measures to provide care optimized to the individual patient's needs. (Less)
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Contribution to journal
publication status
published
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Parkinsonism & Related Disorders
volume
21
issue
7
pages
675 - 682
publisher
Elsevier
external identifiers
  • pmid:25952959
  • wos:000357360000002
  • scopus:84930761245
ISSN
1873-5126
DOI
10.1016/j.parkreldis.2015.04.029
language
English
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yes
id
6d835d4d-f89e-417e-a446-f2365761310e (old id 5456660)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25952959?dopt=Abstract
date added to LUP
2015-06-04 14:44:22
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2017-02-05 03:05:19
@article{6d835d4d-f89e-417e-a446-f2365761310e,
  abstract     = {Parkinson disease (PD) is associated with a clinical course of variable duration, severity, and a combination of motor and non-motor features. Recent PD research has focused primarily on etiology rather than clinical progression and long-term outcomes. For the PD patient, caregivers, and clinicians, information on expected clinical progression and long-term outcomes is of great importance. Today, it remains largely unknown what factors influence long-term clinical progression and outcomes in PD; recent data indicate that the factors that increase the risk to develop PD differ, at least partly, from those that accelerate clinical progression and lead to worse outcomes. Prospective studies will be required to identify factors that influence progression and outcome. We suggest that data for such studies is collected during routine office visits in order to guarantee high external validity of such research. We report here the results of a consensus meeting of international movement disorder experts from the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium, who convened to define which long-term outcomes are of interest to patients, caregivers and clinicians, and what is presently known about environmental or genetic factors influencing clinical progression or long-term outcomes in PD. We propose a panel of rating scales that collects a significant amount of phenotypic information, can be performed in the routine office visit and allows international standardization. Research into the progression and long-term outcomes of PD aims at providing individual prognostic information early, adapting treatment choices, and taking specific measures to provide care optimized to the individual patient's needs.},
  author       = {Puschmann, Andreas and Brighina, Laura and Markopoulou, Katerina and Aasly, Jan and Chung, Sun Ju and Frigerio, Roberta and Hadjigeorgiou, Georgios and Kõks, Sulev and Krüger, Rejko and Siuda, Joanna and Wider, Christian and Zesiewicz, Theresa A and Maraganore, Demetrius M},
  issn         = {1873-5126},
  language     = {eng},
  number       = {7},
  pages        = {675--682},
  publisher    = {Elsevier},
  series       = {Parkinsonism & Related Disorders},
  title        = {Clinically meaningful parameters of progression and long-term outcome of Parkinson disease: An international consensus statement.},
  url          = {http://dx.doi.org/10.1016/j.parkreldis.2015.04.029},
  volume       = {21},
  year         = {2015},
}