Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.
(2015) In Cardiovascular Research 107(1). p.20-31- Abstract
- Excessive vascular cell proliferation is an important component of pulmonary hypertension (PH). Perlecan is the major heparan sulfate (HS) proteoglycan in the vascular extracellular matrix. It binds growth factors, including FGF2, and either restricts or promotes cell proliferation. In this study, we have explored the effects of perlecan HS deficiency on pulmonary vascular development and in hypoxia-induced PH.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5456676
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cardiovascular Research
- volume
- 107
- issue
- 1
- pages
- 20 - 31
- publisher
- Oxford University Press
- external identifiers
-
- pmid:25952902
- wos:000359088800006
- scopus:84936769136
- pmid:25952902
- ISSN
- 1755-3245
- DOI
- 10.1093/cvr/cvv143
- language
- English
- LU publication?
- yes
- id
- 9040adae-2619-4a4f-a916-5c6d755474e7 (old id 5456676)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25952902?dopt=Abstract
- date added to LUP
- 2016-04-01 11:12:49
- date last changed
- 2022-03-12 20:38:14
@article{9040adae-2619-4a4f-a916-5c6d755474e7, abstract = {{Excessive vascular cell proliferation is an important component of pulmonary hypertension (PH). Perlecan is the major heparan sulfate (HS) proteoglycan in the vascular extracellular matrix. It binds growth factors, including FGF2, and either restricts or promotes cell proliferation. In this study, we have explored the effects of perlecan HS deficiency on pulmonary vascular development and in hypoxia-induced PH.}}, author = {{Chang, Ya-Ting and Tseng, Chi-Nan and Tannenberg, Philip and Eriksson, Linnéa and Yuan, Ke and de Jesus Perez, Vinicio A and Lundberg, Johan and Lengquist, Mariette and Botusan, Ileana Ruxandra and Catrina, Sergiu-Bogdan and Tran, Phan-Kiet and Hedin, Ulf and Tran Lundmark, Karin}}, issn = {{1755-3245}}, language = {{eng}}, number = {{1}}, pages = {{20--31}}, publisher = {{Oxford University Press}}, series = {{Cardiovascular Research}}, title = {{Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.}}, url = {{http://dx.doi.org/10.1093/cvr/cvv143}}, doi = {{10.1093/cvr/cvv143}}, volume = {{107}}, year = {{2015}}, }