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Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.

Chang, Ya-Ting; Tseng, Chi-Nan; Tannenberg, Philip; Eriksson, Linnéa; Yuan, Ke; de Jesus Perez, Vinicio A; Lundberg, Johan; Lengquist, Mariette; Botusan, Ileana Ruxandra and Catrina, Sergiu-Bogdan, et al. (2015) In Cardiovascular Research 107(1). p.20-31
Abstract
Excessive vascular cell proliferation is an important component of pulmonary hypertension (PH). Perlecan is the major heparan sulfate (HS) proteoglycan in the vascular extracellular matrix. It binds growth factors, including FGF2, and either restricts or promotes cell proliferation. In this study, we have explored the effects of perlecan HS deficiency on pulmonary vascular development and in hypoxia-induced PH.
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type
Contribution to journal
publication status
published
subject
in
Cardiovascular Research
volume
107
issue
1
pages
20 - 31
publisher
Elsevier
external identifiers
  • pmid:25952902
  • wos:000359088800006
  • scopus:84936769136
ISSN
1755-3245
DOI
10.1093/cvr/cvv143
language
English
LU publication?
yes
id
9040adae-2619-4a4f-a916-5c6d755474e7 (old id 5456676)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25952902?dopt=Abstract
date added to LUP
2015-06-04 14:47:13
date last changed
2017-03-12 03:20:57
@article{9040adae-2619-4a4f-a916-5c6d755474e7,
  abstract     = {Excessive vascular cell proliferation is an important component of pulmonary hypertension (PH). Perlecan is the major heparan sulfate (HS) proteoglycan in the vascular extracellular matrix. It binds growth factors, including FGF2, and either restricts or promotes cell proliferation. In this study, we have explored the effects of perlecan HS deficiency on pulmonary vascular development and in hypoxia-induced PH.},
  author       = {Chang, Ya-Ting and Tseng, Chi-Nan and Tannenberg, Philip and Eriksson, Linnéa and Yuan, Ke and de Jesus Perez, Vinicio A and Lundberg, Johan and Lengquist, Mariette and Botusan, Ileana Ruxandra and Catrina, Sergiu-Bogdan and Tran, Phan-Kiet and Hedin, Ulf and Tran Lundmark, Karin},
  issn         = {1755-3245},
  language     = {eng},
  number       = {1},
  pages        = {20--31},
  publisher    = {Elsevier},
  series       = {Cardiovascular Research},
  title        = {Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.},
  url          = {http://dx.doi.org/10.1093/cvr/cvv143},
  volume       = {107},
  year         = {2015},
}