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Coffee, tea and melanoma risk : findings from the European Prospective Investigation into Cancer and Nutrition

Caini, Saverio; Masala, Giovanna; Saieva, Calogero; Kvaskoff, Marina; Savoye, Isabelle; Sacerdote, Carlotta; Hemmingsson, Oskar; Hammer Bech, Bodil; Overvad, Kim and Tjønneland, Anne, et al. (2017) In International Journal of Cancer 140(10). p.2246-2255
Abstract

In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25–70 years from ten European countries in 1992–2000. Information on coffee and tea drinking was collected at baseline using validated country-specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios... (More)

In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25–70 years from ten European countries in 1992–2000. Information on coffee and tea drinking was collected at baseline using validated country-specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) for the associations between coffee and tea consumption and melanoma risk. Overall, 2,712 melanoma cases were identified during a median follow-up of 14.9 years among 476,160 study participants. Consumption of caffeinated coffee was inversely associated with melanoma risk among men (HR for highest quartile of consumption vs. non-consumers 0.31, 95% CI 0.14–0.69) but not among women (HR 0.96, 95% CI 0.62–1.47). There were no statistically significant associations between consumption of decaffeinated coffee or tea and the risk of melanoma among both men and women. The consumption of caffeinated coffee was inversely associated with melanoma risk among men in this large cohort study. Further investigations are warranted to confirm our findings and clarify the possible role of caffeine and other coffee compounds in reducing the risk of melanoma.

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keywords
coffee, cohort study, melanoma, risk, tea
in
International Journal of Cancer
volume
140
issue
10
pages
10 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85014749425
  • pmid:28218395
  • wos:000399313200008
ISSN
0020-7136
DOI
10.1002/ijc.30659
language
English
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yes
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5485d25b-8040-4a1e-ac4e-89edc8510bb2
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2017-04-10 15:56:00
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2018-10-16 02:31:59
@article{5485d25b-8040-4a1e-ac4e-89edc8510bb2,
  abstract     = {<p>In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25–70 years from ten European countries in 1992–2000. Information on coffee and tea drinking was collected at baseline using validated country-specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) for the associations between coffee and tea consumption and melanoma risk. Overall, 2,712 melanoma cases were identified during a median follow-up of 14.9 years among 476,160 study participants. Consumption of caffeinated coffee was inversely associated with melanoma risk among men (HR for highest quartile of consumption vs. non-consumers 0.31, 95% CI 0.14–0.69) but not among women (HR 0.96, 95% CI 0.62–1.47). There were no statistically significant associations between consumption of decaffeinated coffee or tea and the risk of melanoma among both men and women. The consumption of caffeinated coffee was inversely associated with melanoma risk among men in this large cohort study. Further investigations are warranted to confirm our findings and clarify the possible role of caffeine and other coffee compounds in reducing the risk of melanoma.</p>},
  author       = {Caini, Saverio and Masala, Giovanna and Saieva, Calogero and Kvaskoff, Marina and Savoye, Isabelle and Sacerdote, Carlotta and Hemmingsson, Oskar and Hammer Bech, Bodil and Overvad, Kim and Tjønneland, Anne and Petersen, Kristina E N and Mancini, Francesca Romana and Boutron-Ruault,, Marie-Christine and Cervenka, Iris and Kaaks, Rudolf and Kühn, Tilman and Boeing, Heiner and Floegel, Anna and Trichopoulou, Antonia and Valanou, Elisavet and Kritikou, Maria and Tagliabue, Giovanna and Panico, Salvatore and Tumino, Rosario and Bueno-De-Mesquita, Bas H. and Peeters, Petra H. and Veierød, Marit B. and Ghiasvand, Reza and Lukic, Marko and Quirós, José Ramón and Chirlaque, Maria Dolores and Ardanaz, Eva and Salamanca Fernández, Elena and Larrañaga, Nerea and Zamora-Ros, Raul and Maria Nilsson, Lena and Ljuslinder, Ingrid and Jirström, Karin and Sonestedt, Emily and Key, Timothy J and Wareham, Nick and Khaw, Kay Tee and Gunter, Marc and Huybrechts, Inge and Murphy, Neil and Tsilidis, Konstantinos K. and Weiderpass, Elisabete and Palli, Domenico},
  issn         = {0020-7136},
  keyword      = {coffee,cohort study,melanoma,risk,tea},
  language     = {eng},
  month        = {05},
  number       = {10},
  pages        = {2246--2255},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Coffee, tea and melanoma risk : findings from the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.30659},
  volume       = {140},
  year         = {2017},
}