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Bone Traits Seem to Develop Also During the Third Decade in Life-Normative Cross-Sectional Data on 1083 Men Aged 18-28 Years

Lindgren, Erik LU ; Karlsson, Magnus K. LU ; Lorentzon, Mattias and Rosengren, Björn LU (2017) In Journal of Clinical Densitometry 20(1). p.32-43
Abstract

By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined separately. Because each of these traits contributes independently to bone strength, it is probable that pQCT provides an even better fracture risk estimation than DXA. Currently, the clinical applications of pQCT are limited partly because comprehensive normative pQCT data, especially in young men, are not readily available. We therefore set up a... (More)

By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined separately. Because each of these traits contributes independently to bone strength, it is probable that pQCT provides an even better fracture risk estimation than DXA. Currently, the clinical applications of pQCT are limited partly because comprehensive normative pQCT data, especially in young men, are not readily available. We therefore set up a study in young men with the following objectives: (1) to identify peak ages in pQCT bone traits with special reference to PBM and peak bone strength; and (2) to provide normative pQCT data. We measured volumetric bone mineral density and structural parameters at . ultradistal (trabecular bone) and . diaphyseal radius and . tibia (cortical bone) by pQCT scans (Stratec XCT2000®; Stratec Medizintechnik GmbH, Pforzheim, Germany) in a population-based age-stratified sample of 1083 men aged 18-28 yr residing in greater Malmö, Sweden. Group differences in 1-yr classes were evaluated by analysis of variance. We found similar bone traits in age groups at . ultradistal sites whereas most bone traits at . diaphyseal sites were higher with higher ages, however with different increment patterns depending on the specific trait. In Swedish young adult men, we found that different bone traits continued to change after age 18, but at different rates, indicating that peak areal bone mineral density (as measured by DXA) and peak bone strength may be reached at different ages.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone mass, Bone size, Males, Normative, PQCT
in
Journal of Clinical Densitometry
volume
20
issue
1
pages
32 - 43
publisher
Elsevier
external identifiers
  • scopus:84995902331
  • wos:000395849400006
ISSN
1094-6950
DOI
10.1016/j.jocd.2016.07.002
language
English
LU publication?
yes
id
54a83eea-ccd9-4a0d-bc89-725496f00892
date added to LUP
2016-12-02 13:38:52
date last changed
2018-01-07 11:38:07
@article{54a83eea-ccd9-4a0d-bc89-725496f00892,
  abstract     = {<p>By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined separately. Because each of these traits contributes independently to bone strength, it is probable that pQCT provides an even better fracture risk estimation than DXA. Currently, the clinical applications of pQCT are limited partly because comprehensive normative pQCT data, especially in young men, are not readily available. We therefore set up a study in young men with the following objectives: (1) to identify peak ages in pQCT bone traits with special reference to PBM and peak bone strength; and (2) to provide normative pQCT data. We measured volumetric bone mineral density and structural parameters at . ultradistal (trabecular bone) and . diaphyseal radius and . tibia (cortical bone) by pQCT scans (Stratec XCT2000®; Stratec Medizintechnik GmbH, Pforzheim, Germany) in a population-based age-stratified sample of 1083 men aged 18-28 yr residing in greater Malmö, Sweden. Group differences in 1-yr classes were evaluated by analysis of variance. We found similar bone traits in age groups at . ultradistal sites whereas most bone traits at . diaphyseal sites were higher with higher ages, however with different increment patterns depending on the specific trait. In Swedish young adult men, we found that different bone traits continued to change after age 18, but at different rates, indicating that peak areal bone mineral density (as measured by DXA) and peak bone strength may be reached at different ages.</p>},
  author       = {Lindgren, Erik and Karlsson, Magnus K. and Lorentzon, Mattias and Rosengren, Björn},
  issn         = {1094-6950},
  keyword      = {Bone mass,Bone size,Males,Normative,PQCT},
  language     = {eng},
  number       = {1},
  pages        = {32--43},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Densitometry},
  title        = {Bone Traits Seem to Develop Also During the Third Decade in Life-Normative Cross-Sectional Data on 1083 Men Aged 18-28 Years},
  url          = {http://dx.doi.org/10.1016/j.jocd.2016.07.002},
  volume       = {20},
  year         = {2017},
}