Bone Traits Seem to Develop Also During the Third Decade in Life-Normative Cross-Sectional Data on 1083 Men Aged 18-28 Years
(2017) In Journal of Clinical Densitometry 20(1). p.32-43- Abstract
By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined separately. Because each of these traits contributes independently to bone strength, it is probable that pQCT provides an even better fracture risk estimation than DXA. Currently, the clinical applications of pQCT are limited partly because comprehensive normative pQCT data, especially in young men, are not readily available. We therefore set up a... (More)
By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined separately. Because each of these traits contributes independently to bone strength, it is probable that pQCT provides an even better fracture risk estimation than DXA. Currently, the clinical applications of pQCT are limited partly because comprehensive normative pQCT data, especially in young men, are not readily available. We therefore set up a study in young men with the following objectives: (1) to identify peak ages in pQCT bone traits with special reference to PBM and peak bone strength; and (2) to provide normative pQCT data. We measured volumetric bone mineral density and structural parameters at . ultradistal (trabecular bone) and . diaphyseal radius and . tibia (cortical bone) by pQCT scans (Stratec XCT2000®; Stratec Medizintechnik GmbH, Pforzheim, Germany) in a population-based age-stratified sample of 1083 men aged 18-28 yr residing in greater Malmö, Sweden. Group differences in 1-yr classes were evaluated by analysis of variance. We found similar bone traits in age groups at . ultradistal sites whereas most bone traits at . diaphyseal sites were higher with higher ages, however with different increment patterns depending on the specific trait. In Swedish young adult men, we found that different bone traits continued to change after age 18, but at different rates, indicating that peak areal bone mineral density (as measured by DXA) and peak bone strength may be reached at different ages.
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- author
- Lindgren, Erik LU ; Karlsson, Magnus K. LU ; Lorentzon, Mattias and Rosengren, Björn LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bone mass, Bone size, Males, Normative, PQCT
- in
- Journal of Clinical Densitometry
- volume
- 20
- issue
- 1
- pages
- 32 - 43
- publisher
- Elsevier
- external identifiers
-
- pmid:27546559
- wos:000395849400006
- scopus:84995902331
- ISSN
- 1094-6950
- DOI
- 10.1016/j.jocd.2016.07.002
- project
- Skeletal Development in Young Adults
- language
- English
- LU publication?
- yes
- id
- 54a83eea-ccd9-4a0d-bc89-725496f00892
- date added to LUP
- 2016-12-02 13:38:52
- date last changed
- 2025-01-12 16:28:04
@article{54a83eea-ccd9-4a0d-bc89-725496f00892,
abstract = {{<p>By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined separately. Because each of these traits contributes independently to bone strength, it is probable that pQCT provides an even better fracture risk estimation than DXA. Currently, the clinical applications of pQCT are limited partly because comprehensive normative pQCT data, especially in young men, are not readily available. We therefore set up a study in young men with the following objectives: (1) to identify peak ages in pQCT bone traits with special reference to PBM and peak bone strength; and (2) to provide normative pQCT data. We measured volumetric bone mineral density and structural parameters at . ultradistal (trabecular bone) and . diaphyseal radius and . tibia (cortical bone) by pQCT scans (Stratec XCT2000®; Stratec Medizintechnik GmbH, Pforzheim, Germany) in a population-based age-stratified sample of 1083 men aged 18-28 yr residing in greater Malmö, Sweden. Group differences in 1-yr classes were evaluated by analysis of variance. We found similar bone traits in age groups at . ultradistal sites whereas most bone traits at . diaphyseal sites were higher with higher ages, however with different increment patterns depending on the specific trait. In Swedish young adult men, we found that different bone traits continued to change after age 18, but at different rates, indicating that peak areal bone mineral density (as measured by DXA) and peak bone strength may be reached at different ages.</p>}},
author = {{Lindgren, Erik and Karlsson, Magnus K. and Lorentzon, Mattias and Rosengren, Björn}},
issn = {{1094-6950}},
keywords = {{Bone mass; Bone size; Males; Normative; PQCT}},
language = {{eng}},
number = {{1}},
pages = {{32--43}},
publisher = {{Elsevier}},
series = {{Journal of Clinical Densitometry}},
title = {{Bone Traits Seem to Develop Also During the Third Decade in Life-Normative Cross-Sectional Data on 1083 Men Aged 18-28 Years}},
url = {{http://dx.doi.org/10.1016/j.jocd.2016.07.002}},
doi = {{10.1016/j.jocd.2016.07.002}},
volume = {{20}},
year = {{2017}},
}