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Serum Iodine and Breast Cancer Risk : A Prospective Nested Case-Control Study Stratified for Selenium Levels

Manjer, Jonas LU ; Sandsveden, Malte LU and Borgquist, Signe LU (2020) In Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29(7). p.1335-1340
Abstract

BACKGROUND: Iodine has been suggested to protect against breast cancer, but there are no epidemiologic studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g., Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g., United States), or in areas where both are low (e.g., Northern Europe). The aim of this study was to investigate the association between prediagnostic serum iodine levels and subsequent breast cancer risk, and to investigate if this potential association was modified by selenium levels. METHODS: The Malmö Diet and Cancer Study provided prediagnostic serum samples and the current analysis included 1,159... (More)

BACKGROUND: Iodine has been suggested to protect against breast cancer, but there are no epidemiologic studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g., Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g., United States), or in areas where both are low (e.g., Northern Europe). The aim of this study was to investigate the association between prediagnostic serum iodine levels and subsequent breast cancer risk, and to investigate if this potential association was modified by selenium levels. METHODS: The Malmö Diet and Cancer Study provided prediagnostic serum samples and the current analysis included 1,159 breast cancer cases and 1,136 controls. Levels of baseline serum iodine and selenium were analyzed. A logistic regression analysis yielded ORs with 95% confidence intervals adjusted for potential confounders. RESULTS: There was no evidence of an overall association between iodine levels and risk of breast cancer. Among women with high selenium levels (above the median), high iodine levels were associated with a lower risk of breast cancer; the OR for above versus below the median was 0.75 (0.57-0.99). The corresponding OR for women with low selenium was 1.15 (0.87-1.50), and the Pinteraction was 0.06. CONCLUSIONS: The combination of high serum iodine levels and high selenium levels was associated with a lower risk of breast cancer. IMPACT: A high iodine and selenium exposure may decrease the risk of breast cancer.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
volume
29
issue
7
pages
6 pages
publisher
American Association for Cancer Research
external identifiers
  • pmid:32457181
  • scopus:85087531008
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-20-0122
language
English
LU publication?
yes
id
54e22227-bcf5-4b84-8865-8a9188ddf567
date added to LUP
2020-07-15 12:24:08
date last changed
2024-04-03 10:39:03
@article{54e22227-bcf5-4b84-8865-8a9188ddf567,
  abstract     = {{<p>BACKGROUND: Iodine has been suggested to protect against breast cancer, but there are no epidemiologic studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g., Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g., United States), or in areas where both are low (e.g., Northern Europe). The aim of this study was to investigate the association between prediagnostic serum iodine levels and subsequent breast cancer risk, and to investigate if this potential association was modified by selenium levels. METHODS: The Malmö Diet and Cancer Study provided prediagnostic serum samples and the current analysis included 1,159 breast cancer cases and 1,136 controls. Levels of baseline serum iodine and selenium were analyzed. A logistic regression analysis yielded ORs with 95% confidence intervals adjusted for potential confounders. RESULTS: There was no evidence of an overall association between iodine levels and risk of breast cancer. Among women with high selenium levels (above the median), high iodine levels were associated with a lower risk of breast cancer; the OR for above versus below the median was 0.75 (0.57-0.99). The corresponding OR for women with low selenium was 1.15 (0.87-1.50), and the Pinteraction was 0.06. CONCLUSIONS: The combination of high serum iodine levels and high selenium levels was associated with a lower risk of breast cancer. IMPACT: A high iodine and selenium exposure may decrease the risk of breast cancer.</p>}},
  author       = {{Manjer, Jonas and Sandsveden, Malte and Borgquist, Signe}},
  issn         = {{1538-7755}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1335--1340}},
  publisher    = {{American Association for Cancer Research}},
  series       = {{Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}},
  title        = {{Serum Iodine and Breast Cancer Risk : A Prospective Nested Case-Control Study Stratified for Selenium Levels}},
  url          = {{http://dx.doi.org/10.1158/1055-9965.EPI-20-0122}},
  doi          = {{10.1158/1055-9965.EPI-20-0122}},
  volume       = {{29}},
  year         = {{2020}},
}