Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study

Uusitalo, Ulla ; Mramba, Lazarus K ; Aronsson, CarinAndrén LU orcid ; Vehik, Kendra LU ; Yang, Jimin ; Hummel, Sandra ; Lernmark, Åke LU orcid ; Rewers, Marian ; Hagopian, William and McIndoe, Richard , et al. (2023) In Diabetes Care 46(10). p.1839-1847
Abstract

OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).

RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.

RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an... (More)

OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).

RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.

RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA.

CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
46
issue
10
pages
1839 - 1847
publisher
American Diabetes Association
external identifiers
  • scopus:85171901402
  • pmid:37579501
ISSN
1935-5548
DOI
10.2337/dc23-0417
language
English
LU publication?
yes
additional info
© 2023 by the American Diabetes Association.
id
55338dc4-fdd5-4a3a-9743-d98475fd7dc2
date added to LUP
2023-08-18 14:41:04
date last changed
2024-04-14 16:53:13
@article{55338dc4-fdd5-4a3a-9743-d98475fd7dc2,
  abstract     = {{<p>OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).</p><p>RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.</p><p>RESULTS: Any solid food introduced early (&lt;6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA.</p><p>CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.</p>}},
  author       = {{Uusitalo, Ulla and Mramba, Lazarus K and Aronsson, CarinAndrén and Vehik, Kendra and Yang, Jimin and Hummel, Sandra and Lernmark, Åke and Rewers, Marian and Hagopian, William and McIndoe, Richard and Toppari, Jorma and Ziegler, Anette-G and Akolkar, Beena and Krischer, Jeffrey P and Virtanen, Suvi M and Norris, Jill M}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{10}},
  pages        = {{1839--1847}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study}},
  url          = {{http://dx.doi.org/10.2337/dc23-0417}},
  doi          = {{10.2337/dc23-0417}},
  volume       = {{46}},
  year         = {{2023}},
}