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HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study

Uusitalo, Ulla ; Mramba, Lazarus K ; Aronsson, CarinAndrén LU orcid ; Vehik, Kendra LU ; Yang, Jimin ; Hummel, Sandra ; Lernmark, Åke LU orcid ; Rewers, Marian ; Hagopian, William and McIndoe, Richard , et al. (2023) In Diabetes Care 46(10). p.1839-1847
Abstract

OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).

RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.

RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an... (More)

OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).

RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.

RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA.

CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
46
issue
10
pages
1839 - 1847
publisher
American Diabetes Association
external identifiers
  • scopus:85171901402
  • pmid:37579501
ISSN
1935-5548
DOI
10.2337/dc23-0417
language
English
LU publication?
yes
additional info
© 2023 by the American Diabetes Association.
id
55338dc4-fdd5-4a3a-9743-d98475fd7dc2
date added to LUP
2023-08-18 14:41:04
date last changed
2024-10-28 12:32:01
@article{55338dc4-fdd5-4a3a-9743-d98475fd7dc2,
  abstract     = {{<p>OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).</p><p>RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.</p><p>RESULTS: Any solid food introduced early (&lt;6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA.</p><p>CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.</p>}},
  author       = {{Uusitalo, Ulla and Mramba, Lazarus K and Aronsson, CarinAndrén and Vehik, Kendra and Yang, Jimin and Hummel, Sandra and Lernmark, Åke and Rewers, Marian and Hagopian, William and McIndoe, Richard and Toppari, Jorma and Ziegler, Anette-G and Akolkar, Beena and Krischer, Jeffrey P and Virtanen, Suvi M and Norris, Jill M}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{10}},
  pages        = {{1839--1847}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study}},
  url          = {{http://dx.doi.org/10.2337/dc23-0417}},
  doi          = {{10.2337/dc23-0417}},
  volume       = {{46}},
  year         = {{2023}},
}