HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study
(2023) In Diabetes Care 46(10). p.1839-1847- Abstract
OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).
RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.
RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an... (More)
OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).
RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.
RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA.
CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2023-08-14
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 46
- issue
- 10
- pages
- 1839 - 1847
- publisher
- American Diabetes Association
- external identifiers
-
- scopus:85171901402
- pmid:37579501
- ISSN
- 1935-5548
- DOI
- 10.2337/dc23-0417
- language
- English
- LU publication?
- yes
- additional info
- © 2023 by the American Diabetes Association.
- id
- 55338dc4-fdd5-4a3a-9743-d98475fd7dc2
- date added to LUP
- 2023-08-18 14:41:04
- date last changed
- 2024-10-28 12:32:01
@article{55338dc4-fdd5-4a3a-9743-d98475fd7dc2, abstract = {{<p>OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).</p><p>RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.</p><p>RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA.</p><p>CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.</p>}}, author = {{Uusitalo, Ulla and Mramba, Lazarus K and Aronsson, CarinAndrén and Vehik, Kendra and Yang, Jimin and Hummel, Sandra and Lernmark, Åke and Rewers, Marian and Hagopian, William and McIndoe, Richard and Toppari, Jorma and Ziegler, Anette-G and Akolkar, Beena and Krischer, Jeffrey P and Virtanen, Suvi M and Norris, Jill M}}, issn = {{1935-5548}}, language = {{eng}}, month = {{08}}, number = {{10}}, pages = {{1839--1847}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study}}, url = {{http://dx.doi.org/10.2337/dc23-0417}}, doi = {{10.2337/dc23-0417}}, volume = {{46}}, year = {{2023}}, }