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Family Genetic-Risk Profiles Associated With Divorce

Salvatore, Jessica E. ; Ohlsson, Henrik LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Kendler, Kenneth S. (2024) In Clinical Psychological Science
Abstract

We used Swedish national-register data (N = 2,828,777) to examine divorce and its associated patterns of family genetic-risk scores (FGRSs; personalized measures of genetic risk inferred from diagnoses in relatives) across 10 psychiatric disorders: major depression, anxiety disorders, obsessive compulsive disorder, bipolar disorder, schizophrenia, anorexia nervosa, alcohol use disorder, drug use disorder, attention-deficit/hyperactive disorder, and autism spectrum disorder. Individuals who divorced had elevated FGRSs across all disorders compared with individuals who were stably married or never married. FGRSs for all disorders were higher among divorced females compared with divorced males and among individuals who did not go on to... (More)

We used Swedish national-register data (N = 2,828,777) to examine divorce and its associated patterns of family genetic-risk scores (FGRSs; personalized measures of genetic risk inferred from diagnoses in relatives) across 10 psychiatric disorders: major depression, anxiety disorders, obsessive compulsive disorder, bipolar disorder, schizophrenia, anorexia nervosa, alcohol use disorder, drug use disorder, attention-deficit/hyperactive disorder, and autism spectrum disorder. Individuals who divorced had elevated FGRSs across all disorders compared with individuals who were stably married or never married. FGRSs for all disorders were higher among divorced females compared with divorced males and among individuals who did not go on to have a stable second marriage compared with individuals who had a stable second marriage and increased as the cumulative number of divorces increased. In summary, genetic predispositions for psychiatric disorders are associated with the propensity to divorce and with several differences as a function of sex, remarriage, and the cumulative number of divorce transitions.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
divorce, family genetic-risk scores, psychiatric disorders, remarriage
in
Clinical Psychological Science
publisher
SAGE Publications
external identifiers
  • scopus:85184446948
ISSN
2167-7026
DOI
10.1177/21677026231214204
language
English
LU publication?
yes
id
554e7229-bd68-4296-9db1-6d14f02dcfce
date added to LUP
2024-03-08 12:35:46
date last changed
2024-03-08 12:36:14
@article{554e7229-bd68-4296-9db1-6d14f02dcfce,
  abstract     = {{<p>We used Swedish national-register data (N = 2,828,777) to examine divorce and its associated patterns of family genetic-risk scores (FGRSs; personalized measures of genetic risk inferred from diagnoses in relatives) across 10 psychiatric disorders: major depression, anxiety disorders, obsessive compulsive disorder, bipolar disorder, schizophrenia, anorexia nervosa, alcohol use disorder, drug use disorder, attention-deficit/hyperactive disorder, and autism spectrum disorder. Individuals who divorced had elevated FGRSs across all disorders compared with individuals who were stably married or never married. FGRSs for all disorders were higher among divorced females compared with divorced males and among individuals who did not go on to have a stable second marriage compared with individuals who had a stable second marriage and increased as the cumulative number of divorces increased. In summary, genetic predispositions for psychiatric disorders are associated with the propensity to divorce and with several differences as a function of sex, remarriage, and the cumulative number of divorce transitions.</p>}},
  author       = {{Salvatore, Jessica E. and Ohlsson, Henrik and Sundquist, Jan and Sundquist, Kristina and Kendler, Kenneth S.}},
  issn         = {{2167-7026}},
  keywords     = {{divorce; family genetic-risk scores; psychiatric disorders; remarriage}},
  language     = {{eng}},
  publisher    = {{SAGE Publications}},
  series       = {{Clinical Psychological Science}},
  title        = {{Family Genetic-Risk Profiles Associated With Divorce}},
  url          = {{http://dx.doi.org/10.1177/21677026231214204}},
  doi          = {{10.1177/21677026231214204}},
  year         = {{2024}},
}