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It doesn’t always pay to be fit : success landscapes

Phan, Trung V. ; Wang, Gao ; Do, Tuan K. ; Kevrekidis, Ioannis G. ; Amend, Sarah ; Hammarlund, Emma LU ; Pienta, Ken ; Brown, Joel ; Liu, Liyu and Austin, Robert H. (2021) In Journal of Biological Physics 47(4). p.387-400
Abstract

Landscapes play an important role in many areas of biology, in which biological lives are deeply entangled. Here we discuss a form of landscape in evolutionary biology which takes into account (1) initial growth rates, (2) mutation rates, (3) resource consumption by organisms, and (4) cyclic changes in the resources with time. The long-term equilibrium number of surviving organisms as a function of these four parameters forms what we call a success landscape, a landscape we would claim is qualitatively different from fitness landscapes which commonly do not include mutations or resource consumption/changes in mapping genomes to the final number of survivors. Although our analysis is purely theoretical, we believe the results have... (More)

Landscapes play an important role in many areas of biology, in which biological lives are deeply entangled. Here we discuss a form of landscape in evolutionary biology which takes into account (1) initial growth rates, (2) mutation rates, (3) resource consumption by organisms, and (4) cyclic changes in the resources with time. The long-term equilibrium number of surviving organisms as a function of these four parameters forms what we call a success landscape, a landscape we would claim is qualitatively different from fitness landscapes which commonly do not include mutations or resource consumption/changes in mapping genomes to the final number of survivors. Although our analysis is purely theoretical, we believe the results have possibly strong connections to how we might treat diseases such as cancer in the future with a deeper understanding of the interplay between resource degradation, mutation, and uncontrolled cell growth.

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; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer, Evolution dynamics, Extinction, Fitness, Landscapes, Mutations, Resources
in
Journal of Biological Physics
volume
47
issue
4
pages
387 - 400
publisher
Springer
external identifiers
  • scopus:85118214394
  • pmid:34709534
ISSN
0092-0606
DOI
10.1007/s10867-021-09589-2
language
English
LU publication?
yes
additional info
Funding Information: We would like to thank Hans Frauenfelder, without whom this subject would have remained strictly the province of ecologists, and probably not a success. This work was supported in part by the National Science Foundation, through the Center for the Physics of Biological Function (PHY-1734030). Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature B.V.
id
5579256a-744e-4cc1-8ebe-5530b5134c8c
date added to LUP
2021-11-24 14:52:53
date last changed
2024-06-15 21:29:30
@article{5579256a-744e-4cc1-8ebe-5530b5134c8c,
  abstract     = {{<p>Landscapes play an important role in many areas of biology, in which biological lives are deeply entangled. Here we discuss a form of landscape in evolutionary biology which takes into account (1) initial growth rates, (2) mutation rates, (3) resource consumption by organisms, and (4) cyclic changes in the resources with time. The long-term equilibrium number of surviving organisms as a function of these four parameters forms what we call a success landscape, a landscape we would claim is qualitatively different from fitness landscapes which commonly do not include mutations or resource consumption/changes in mapping genomes to the final number of survivors. Although our analysis is purely theoretical, we believe the results have possibly strong connections to how we might treat diseases such as cancer in the future with a deeper understanding of the interplay between resource degradation, mutation, and uncontrolled cell growth.</p>}},
  author       = {{Phan, Trung V. and Wang, Gao and Do, Tuan K. and Kevrekidis, Ioannis G. and Amend, Sarah and Hammarlund, Emma and Pienta, Ken and Brown, Joel and Liu, Liyu and Austin, Robert H.}},
  issn         = {{0092-0606}},
  keywords     = {{Cancer; Evolution dynamics; Extinction; Fitness; Landscapes; Mutations; Resources}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{387--400}},
  publisher    = {{Springer}},
  series       = {{Journal of Biological Physics}},
  title        = {{It doesn’t always pay to be fit : success landscapes}},
  url          = {{http://dx.doi.org/10.1007/s10867-021-09589-2}},
  doi          = {{10.1007/s10867-021-09589-2}},
  volume       = {{47}},
  year         = {{2021}},
}