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Genetic Effects on Old-Age Cognitive Functioning: A Population-Based Study

Laukka, Erika J. ; Lövdén, Martin LU ; Herlitz, Agneta ; Karlsson, Sari ; Ferencz, Beata ; Pantzar, Alexandra ; Keller, Lina ; Graff, Caroline ; Fratiglioni, Laura and Backman, Lars (2013) In Psychology and Aging 28(1). p.262-274
Abstract
Associations between genotypes and cognitive outcomes may provide clues as to which mechanisms cause individual differences in old-age cognitive performance. We investigated the effects of five polymorphisms on cognitive functioning in a population-based sample of 2,694 persons without dementia (60-102 years). A structural equation model (SEM) was fit to the cognitive data, yielding five specific latent factors (perceptual speed, episodic memory, semantic memory, category fluency, and letter fluency), as well as a global cognitive factor. These factors showed the expected associations with chronological age. Genotyping was performed for five single-nucleotide polymorphisms that have been associated with cognitive performance: APOE... (More)
Associations between genotypes and cognitive outcomes may provide clues as to which mechanisms cause individual differences in old-age cognitive performance. We investigated the effects of five polymorphisms on cognitive functioning in a population-based sample of 2,694 persons without dementia (60-102 years). A structural equation model (SEM) was fit to the cognitive data, yielding five specific latent factors (perceptual speed, episodic memory, semantic memory, category fluency, and letter fluency), as well as a global cognitive factor. These factors showed the expected associations with chronological age. Genotyping was performed for five single-nucleotide polymorphisms that have been associated with cognitive performance: APOE (rs429358), COMT (rs4680), BDNF (rs6265), KIBRA (rs17070145), and CLSTN2 (rs6439886). After controlling for age, gender, and education, as well as correcting for multiple comparisons, we observed negative effects of being an APOE epsilon 4 carrier on episodic memory and perceptual speed. Furthermore, being a CLSTN2 TT carrier was associated with poorer semantic memory. For the global factor, the same pattern of results was observed. In addition, being a BDNF any A carrier was associated with better cognitive performance. Also, older age was associated with stronger genetic effects of APOE on global cognition. However, this interaction effect was partly driven by the presence of preclinical dementia cases in our sample. Similarly, excluding future dementia cases attenuated the effects of APOE on episodic memory and global cognition, suggesting that part of the effects of APOE on old-age cognitive performance may be driven by dementia-related processes. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cognitive aging, genetic, cognition, APOE, perceptual speed, memory
in
Psychology and Aging
volume
28
issue
1
pages
262 - 274
publisher
American Psychological Association (APA)
external identifiers
  • wos:000316591500027
  • scopus:84881246581
  • pmid:23276211
ISSN
0882-7974
DOI
10.1037/a0030829
language
English
LU publication?
yes
id
5579b4af-316c-4842-9328-8f43d9a60991 (old id 3761033)
date added to LUP
2016-04-01 13:14:24
date last changed
2020-12-08 04:14:41
@article{5579b4af-316c-4842-9328-8f43d9a60991,
  abstract     = {Associations between genotypes and cognitive outcomes may provide clues as to which mechanisms cause individual differences in old-age cognitive performance. We investigated the effects of five polymorphisms on cognitive functioning in a population-based sample of 2,694 persons without dementia (60-102 years). A structural equation model (SEM) was fit to the cognitive data, yielding five specific latent factors (perceptual speed, episodic memory, semantic memory, category fluency, and letter fluency), as well as a global cognitive factor. These factors showed the expected associations with chronological age. Genotyping was performed for five single-nucleotide polymorphisms that have been associated with cognitive performance: APOE (rs429358), COMT (rs4680), BDNF (rs6265), KIBRA (rs17070145), and CLSTN2 (rs6439886). After controlling for age, gender, and education, as well as correcting for multiple comparisons, we observed negative effects of being an APOE epsilon 4 carrier on episodic memory and perceptual speed. Furthermore, being a CLSTN2 TT carrier was associated with poorer semantic memory. For the global factor, the same pattern of results was observed. In addition, being a BDNF any A carrier was associated with better cognitive performance. Also, older age was associated with stronger genetic effects of APOE on global cognition. However, this interaction effect was partly driven by the presence of preclinical dementia cases in our sample. Similarly, excluding future dementia cases attenuated the effects of APOE on episodic memory and global cognition, suggesting that part of the effects of APOE on old-age cognitive performance may be driven by dementia-related processes.},
  author       = {Laukka, Erika J. and Lövdén, Martin and Herlitz, Agneta and Karlsson, Sari and Ferencz, Beata and Pantzar, Alexandra and Keller, Lina and Graff, Caroline and Fratiglioni, Laura and Backman, Lars},
  issn         = {0882-7974},
  language     = {eng},
  number       = {1},
  pages        = {262--274},
  publisher    = {American Psychological Association (APA)},
  series       = {Psychology and Aging},
  title        = {Genetic Effects on Old-Age Cognitive Functioning: A Population-Based Study},
  url          = {http://dx.doi.org/10.1037/a0030829},
  doi          = {10.1037/a0030829},
  volume       = {28},
  year         = {2013},
}