Genetic Effects on Old-Age Cognitive Functioning: A Population-Based Study
(2013) In Psychology and Aging 28(1). p.262-274- Abstract
- Associations between genotypes and cognitive outcomes may provide clues as to which mechanisms cause individual differences in old-age cognitive performance. We investigated the effects of five polymorphisms on cognitive functioning in a population-based sample of 2,694 persons without dementia (60-102 years). A structural equation model (SEM) was fit to the cognitive data, yielding five specific latent factors (perceptual speed, episodic memory, semantic memory, category fluency, and letter fluency), as well as a global cognitive factor. These factors showed the expected associations with chronological age. Genotyping was performed for five single-nucleotide polymorphisms that have been associated with cognitive performance: APOE... (More)
- Associations between genotypes and cognitive outcomes may provide clues as to which mechanisms cause individual differences in old-age cognitive performance. We investigated the effects of five polymorphisms on cognitive functioning in a population-based sample of 2,694 persons without dementia (60-102 years). A structural equation model (SEM) was fit to the cognitive data, yielding five specific latent factors (perceptual speed, episodic memory, semantic memory, category fluency, and letter fluency), as well as a global cognitive factor. These factors showed the expected associations with chronological age. Genotyping was performed for five single-nucleotide polymorphisms that have been associated with cognitive performance: APOE (rs429358), COMT (rs4680), BDNF (rs6265), KIBRA (rs17070145), and CLSTN2 (rs6439886). After controlling for age, gender, and education, as well as correcting for multiple comparisons, we observed negative effects of being an APOE epsilon 4 carrier on episodic memory and perceptual speed. Furthermore, being a CLSTN2 TT carrier was associated with poorer semantic memory. For the global factor, the same pattern of results was observed. In addition, being a BDNF any A carrier was associated with better cognitive performance. Also, older age was associated with stronger genetic effects of APOE on global cognition. However, this interaction effect was partly driven by the presence of preclinical dementia cases in our sample. Similarly, excluding future dementia cases attenuated the effects of APOE on episodic memory and global cognition, suggesting that part of the effects of APOE on old-age cognitive performance may be driven by dementia-related processes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3761033
- author
- Laukka, Erika J. ; Lövdén, Martin LU ; Herlitz, Agneta ; Karlsson, Sari ; Ferencz, Beata ; Pantzar, Alexandra ; Keller, Lina ; Graff, Caroline ; Fratiglioni, Laura and Backman, Lars
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cognitive aging, genetic, cognition, APOE, perceptual speed, memory
- in
- Psychology and Aging
- volume
- 28
- issue
- 1
- pages
- 262 - 274
- publisher
- American Psychological Association (APA)
- external identifiers
-
- wos:000316591500027
- scopus:84881246581
- pmid:23276211
- ISSN
- 0882-7974
- DOI
- 10.1037/a0030829
- language
- English
- LU publication?
- yes
- id
- 5579b4af-316c-4842-9328-8f43d9a60991 (old id 3761033)
- date added to LUP
- 2016-04-01 13:14:24
- date last changed
- 2022-03-29 06:18:48
@article{5579b4af-316c-4842-9328-8f43d9a60991,
abstract = {{Associations between genotypes and cognitive outcomes may provide clues as to which mechanisms cause individual differences in old-age cognitive performance. We investigated the effects of five polymorphisms on cognitive functioning in a population-based sample of 2,694 persons without dementia (60-102 years). A structural equation model (SEM) was fit to the cognitive data, yielding five specific latent factors (perceptual speed, episodic memory, semantic memory, category fluency, and letter fluency), as well as a global cognitive factor. These factors showed the expected associations with chronological age. Genotyping was performed for five single-nucleotide polymorphisms that have been associated with cognitive performance: APOE (rs429358), COMT (rs4680), BDNF (rs6265), KIBRA (rs17070145), and CLSTN2 (rs6439886). After controlling for age, gender, and education, as well as correcting for multiple comparisons, we observed negative effects of being an APOE epsilon 4 carrier on episodic memory and perceptual speed. Furthermore, being a CLSTN2 TT carrier was associated with poorer semantic memory. For the global factor, the same pattern of results was observed. In addition, being a BDNF any A carrier was associated with better cognitive performance. Also, older age was associated with stronger genetic effects of APOE on global cognition. However, this interaction effect was partly driven by the presence of preclinical dementia cases in our sample. Similarly, excluding future dementia cases attenuated the effects of APOE on episodic memory and global cognition, suggesting that part of the effects of APOE on old-age cognitive performance may be driven by dementia-related processes.}},
author = {{Laukka, Erika J. and Lövdén, Martin and Herlitz, Agneta and Karlsson, Sari and Ferencz, Beata and Pantzar, Alexandra and Keller, Lina and Graff, Caroline and Fratiglioni, Laura and Backman, Lars}},
issn = {{0882-7974}},
keywords = {{cognitive aging; genetic; cognition; APOE; perceptual speed; memory}},
language = {{eng}},
number = {{1}},
pages = {{262--274}},
publisher = {{American Psychological Association (APA)}},
series = {{Psychology and Aging}},
title = {{Genetic Effects on Old-Age Cognitive Functioning: A Population-Based Study}},
url = {{http://dx.doi.org/10.1037/a0030829}},
doi = {{10.1037/a0030829}},
volume = {{28}},
year = {{2013}},
}