The effects of sociodemographic factors and comorbidities on sepsis: A nationwide Swedish cohort study
Stenberg, Henning LU ; Li, Xinjun LU ; Pello-Esso, Wazah LU ; Lönn, Sara Larsson LU ; Thønnings, Sara ; Khoshnood, Ardavan LU
; Knudsen, Jenny Dahl
; Sundquist, Kristina
LU
and Jansåker, Filip
LU
(2023)
In Preventive Medicine Reports
35(October).
- Abstract
- Sepsis is a severe condition, representing a significant public health concern, especially in the elderly. There is, however, little insight into the potential effects of sociodemographic factors and comorbidities on sepsis incidence and how these factors interact. This was a nationwide open cohort study including individuals (N = 6746010) in Sweden ≥ 18 years of age spanning from 1997 to 2018, with 116175995 person years of follow-up. The outcome was time to first occurrence of sepsis. The following variables were included in the analysis: sociodemographic factors (age, sex, income, education, marital status, region of residency, and country of origin), severe mental disorders (schizophrenia and bipolar disorders), and Charlson... (More)
- Sepsis is a severe condition, representing a significant public health concern, especially in the elderly. There is, however, little insight into the potential effects of sociodemographic factors and comorbidities on sepsis incidence and how these factors interact. This was a nationwide open cohort study including individuals (N = 6746010) in Sweden ≥ 18 years of age spanning from 1997 to 2018, with 116175995 person years of follow-up. The outcome was time to first occurrence of sepsis. The following variables were included in the analysis: sociodemographic factors (age, sex, income, education, marital status, region of residency, and country of origin), severe mental disorders (schizophrenia and bipolar disorders), and Charlson Comorbidity Index. Interaction tests were conducted. A total of 161558 individuals were diagnosed with sepsis during the study period, corresponding to an incidence rate of 13.9 per 10000 person years (95% CI: 13.8 – 14.0). The main findings were that male sex, high age, low education, and comorbid conditions were positively associated with sepsis, after adjustments for the other covariates. Being aged 80 years and above yielded a HR of 18.19 (95% CI: 17.84 – 18.55) and the effect of high age was more than twice as high in men than in women. In conclusion, this large nationwide cohort found that several sociodemographic factors and comorbid conditions were independently associated with sepsis and men were more affected by higher age than women. These findings can help improve sepsis awareness and preventive work in risk groups. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5586c86b-f50b-4900-8319-119ffc6d1ae7
- author
- Stenberg, Henning
LU
; Li, Xinjun
LU
; Pello-Esso, Wazah
LU
; Lönn, Sara Larsson
LU
; Thønnings, Sara
; Khoshnood, Ardavan
LU
; Knudsen, Jenny Dahl
; Sundquist, Kristina
LU
and Jansåker, Filip
LU
- organization
- publishing date
- 2023-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epidemiology, Risk factors, Sepsis, Severe mental disorders, Sociodemographic factors
- in
- Preventive Medicine Reports
- volume
- 35
- issue
- October
- article number
- 102326
- publisher
- Elsevier
- external identifiers
-
- scopus:85165431922
- pmid:37519448
- ISSN
- 2211-3355
- DOI
- 10.1016/j.pmedr.2023.102326
- language
- English
- LU publication?
- yes
- id
- 5586c86b-f50b-4900-8319-119ffc6d1ae7
- date added to LUP
- 2023-07-23 22:16:02
- date last changed
- 2024-02-19 21:54:35
@article{5586c86b-f50b-4900-8319-119ffc6d1ae7,
abstract = {{Sepsis is a severe condition, representing a significant public health concern, especially in the elderly. There is, however, little insight into the potential effects of sociodemographic factors and comorbidities on sepsis incidence and how these factors interact. This was a nationwide open cohort study including individuals (N = 6746010) in Sweden ≥ 18 years of age spanning from 1997 to 2018, with 116175995 person years of follow-up. The outcome was time to first occurrence of sepsis. The following variables were included in the analysis: sociodemographic factors (age, sex, income, education, marital status, region of residency, and country of origin), severe mental disorders (schizophrenia and bipolar disorders), and Charlson Comorbidity Index. Interaction tests were conducted. A total of 161558 individuals were diagnosed with sepsis during the study period, corresponding to an incidence rate of 13.9 per 10000 person years (95% CI: 13.8 – 14.0). The main findings were that male sex, high age, low education, and comorbid conditions were positively associated with sepsis, after adjustments for the other covariates. Being aged 80 years and above yielded a HR of 18.19 (95% CI: 17.84 – 18.55) and the effect of high age was more than twice as high in men than in women. In conclusion, this large nationwide cohort found that several sociodemographic factors and comorbid conditions were independently associated with sepsis and men were more affected by higher age than women. These findings can help improve sepsis awareness and preventive work in risk groups.}},
author = {{Stenberg, Henning and Li, Xinjun and Pello-Esso, Wazah and Lönn, Sara Larsson and Thønnings, Sara and Khoshnood, Ardavan and Knudsen, Jenny Dahl and Sundquist, Kristina and Jansåker, Filip}},
issn = {{2211-3355}},
keywords = {{Epidemiology; Risk factors; Sepsis; Severe mental disorders; Sociodemographic factors}},
language = {{eng}},
number = {{October}},
publisher = {{Elsevier}},
series = {{Preventive Medicine Reports}},
title = {{The effects of sociodemographic factors and comorbidities on sepsis: A nationwide Swedish cohort study}},
url = {{http://dx.doi.org/10.1016/j.pmedr.2023.102326}},
doi = {{10.1016/j.pmedr.2023.102326}},
volume = {{35}},
year = {{2023}},
}