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Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis

Jons, Daniel ; Zetterberg, Henrik ; Biström, Martin ; Alonso-Magdalena, Lucia LU ; Gunnarsson, Martin ; Vrethem, Magnus ; Blennow, Kaj LU ; Nilsson, Staffan ; Sundström, Peter and Andersen, Oluf (2022) In Annals of Clinical and Translational Neurology 9(6). p.882-887
Abstract

Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Clinical and Translational Neurology
volume
9
issue
6
pages
882 - 887
publisher
Wiley-Blackwell
external identifiers
  • pmid:35502756
  • scopus:85129266300
ISSN
2328-9503
DOI
10.1002/acn3.51568
language
English
LU publication?
yes
id
55a09bbb-96f7-46d8-a479-6d13cb75e6e8
date added to LUP
2022-08-15 12:40:07
date last changed
2024-07-11 20:43:34
@article{55a09bbb-96f7-46d8-a479-6d13cb75e6e8,
  abstract     = {{<p>Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p &lt; 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.</p>}},
  author       = {{Jons, Daniel and Zetterberg, Henrik and Biström, Martin and Alonso-Magdalena, Lucia and Gunnarsson, Martin and Vrethem, Magnus and Blennow, Kaj and Nilsson, Staffan and Sundström, Peter and Andersen, Oluf}},
  issn         = {{2328-9503}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{882--887}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Annals of Clinical and Translational Neurology}},
  title        = {{Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis}},
  url          = {{http://dx.doi.org/10.1002/acn3.51568}},
  doi          = {{10.1002/acn3.51568}},
  volume       = {{9}},
  year         = {{2022}},
}