Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
(2022) In Annals of Clinical and Translational Neurology 9(6). p.882-887- Abstract
Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/55a09bbb-96f7-46d8-a479-6d13cb75e6e8
- author
- Jons, Daniel ; Zetterberg, Henrik ; Biström, Martin ; Alonso-Magdalena, Lucia LU ; Gunnarsson, Martin ; Vrethem, Magnus ; Blennow, Kaj LU ; Nilsson, Staffan ; Sundström, Peter and Andersen, Oluf
- organization
- publishing date
- 2022-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Clinical and Translational Neurology
- volume
- 9
- issue
- 6
- pages
- 882 - 887
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85129266300
- pmid:35502756
- ISSN
- 2328-9503
- DOI
- 10.1002/acn3.51568
- language
- English
- LU publication?
- yes
- id
- 55a09bbb-96f7-46d8-a479-6d13cb75e6e8
- date added to LUP
- 2022-08-15 12:40:07
- date last changed
- 2024-10-18 07:59:36
@article{55a09bbb-96f7-46d8-a479-6d13cb75e6e8, abstract = {{<p>Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.</p>}}, author = {{Jons, Daniel and Zetterberg, Henrik and Biström, Martin and Alonso-Magdalena, Lucia and Gunnarsson, Martin and Vrethem, Magnus and Blennow, Kaj and Nilsson, Staffan and Sundström, Peter and Andersen, Oluf}}, issn = {{2328-9503}}, language = {{eng}}, number = {{6}}, pages = {{882--887}}, publisher = {{Wiley-Blackwell}}, series = {{Annals of Clinical and Translational Neurology}}, title = {{Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis}}, url = {{http://dx.doi.org/10.1002/acn3.51568}}, doi = {{10.1002/acn3.51568}}, volume = {{9}}, year = {{2022}}, }