Periodontitis and NAFLD-related diseases : A bidirectional two-sample Mendelian randomization study
(2023) In Oral Diseases- Abstract
Background: Epidemiological studies have shown an association between periodontitis and nonalcoholic fatty liver disease (NAFLD)-related diseases. However, a causal relationship between these two diseases remains unclear. To examine the causal relationship between these two diseases, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis using genetic markers as proxies. Methods: Statistical summary was obtained from a large genome-wide association study (GWAS) on NAFLD (N = 342,499), nonalcoholic steatohepatitis (NASH, N = 342,499), fibrosis (N = 339,081), cirrhosis (N = 342,499), fibrosis/cirrhosis (N = 334,553), and periodontitis (N = 34,615) in the European ancestry. The inverse variance weighted (IVW) method... (More)
Background: Epidemiological studies have shown an association between periodontitis and nonalcoholic fatty liver disease (NAFLD)-related diseases. However, a causal relationship between these two diseases remains unclear. To examine the causal relationship between these two diseases, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis using genetic markers as proxies. Methods: Statistical summary was obtained from a large genome-wide association study (GWAS) on NAFLD (N = 342,499), nonalcoholic steatohepatitis (NASH, N = 342,499), fibrosis (N = 339,081), cirrhosis (N = 342,499), fibrosis/cirrhosis (N = 334,553), and periodontitis (N = 34,615) in the European ancestry. The inverse variance weighted (IVW) method was used as the main method to estimate the bidirectional association. Sensitivity analysis was performed to evaluate the rigidity of the results. Results: Limited evidence indicated positive causal associations between genetically predicted NAFLD and periodontitis (IVW odds ratio [OR], 1.094; 95% confidence interval [CI], 1.006–1.189; p = 0.036) and between cirrhosis and periodontitis (IVW OR, 1.138; 95% CI, 1.001–1.294; p = 0.048). However, the opposite trend did not indicate a causative effect of periodontitis on NAFLD-related diseases. The sensitivity analysis revealed no obvious pleiotropy or heterogeneity. Conclusions: Our MR analysis provides new evidence in favor of the moderate causal impact of NAFLD on periodontitis. The causal effects of periodontitis on NAFLD-related diseases warrant further investigation.
(Less)
- author
- Qiao, Feng ; Li, Xiaoyan ; Liu, Yuchang ; Zhang, Shunming LU ; Liu, Dayong and Li, Changyi
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- epidemiological studies, GWAS, Mendelian randomization, NAFLD-related diseases, periodontitis
- in
- Oral Diseases
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:37877540
- scopus:85174625440
- ISSN
- 1354-523X
- DOI
- 10.1111/odi.14785
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2023 Wiley Periodicals LLC.
- id
- 560248a5-c6f6-4764-b0ec-1ccbf9b36f8e
- date added to LUP
- 2023-12-13 10:49:40
- date last changed
- 2024-04-26 04:25:39
@article{560248a5-c6f6-4764-b0ec-1ccbf9b36f8e, abstract = {{<p>Background: Epidemiological studies have shown an association between periodontitis and nonalcoholic fatty liver disease (NAFLD)-related diseases. However, a causal relationship between these two diseases remains unclear. To examine the causal relationship between these two diseases, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis using genetic markers as proxies. Methods: Statistical summary was obtained from a large genome-wide association study (GWAS) on NAFLD (N = 342,499), nonalcoholic steatohepatitis (NASH, N = 342,499), fibrosis (N = 339,081), cirrhosis (N = 342,499), fibrosis/cirrhosis (N = 334,553), and periodontitis (N = 34,615) in the European ancestry. The inverse variance weighted (IVW) method was used as the main method to estimate the bidirectional association. Sensitivity analysis was performed to evaluate the rigidity of the results. Results: Limited evidence indicated positive causal associations between genetically predicted NAFLD and periodontitis (IVW odds ratio [OR], 1.094; 95% confidence interval [CI], 1.006–1.189; p = 0.036) and between cirrhosis and periodontitis (IVW OR, 1.138; 95% CI, 1.001–1.294; p = 0.048). However, the opposite trend did not indicate a causative effect of periodontitis on NAFLD-related diseases. The sensitivity analysis revealed no obvious pleiotropy or heterogeneity. Conclusions: Our MR analysis provides new evidence in favor of the moderate causal impact of NAFLD on periodontitis. The causal effects of periodontitis on NAFLD-related diseases warrant further investigation.</p>}}, author = {{Qiao, Feng and Li, Xiaoyan and Liu, Yuchang and Zhang, Shunming and Liu, Dayong and Li, Changyi}}, issn = {{1354-523X}}, keywords = {{epidemiological studies; GWAS; Mendelian randomization; NAFLD-related diseases; periodontitis}}, language = {{eng}}, publisher = {{Wiley-Blackwell}}, series = {{Oral Diseases}}, title = {{Periodontitis and NAFLD-related diseases : A bidirectional two-sample Mendelian randomization study}}, url = {{http://dx.doi.org/10.1111/odi.14785}}, doi = {{10.1111/odi.14785}}, year = {{2023}}, }