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Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system

Watabe, Tetsuro ; Takahashi, Kazuki ; Pietras, Kristian LU orcid and Yoshimatsu, Yasuhiro (2023) In Seminars in Cancer Biology 92. p.130-138
Abstract

Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known as endothelial-mesenchymal transition (EndoMT). This plasticity of ECs is mediated by various cytokines, including transforming growth factor-β (TGF-β), and modulated by other stimuli depending on the cellular contexts. Recent lines of evidence have shown that EndoMT is involved in various steps of tumor progression, including tumor... (More)

Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known as endothelial-mesenchymal transition (EndoMT). This plasticity of ECs is mediated by various cytokines, including transforming growth factor-β (TGF-β), and modulated by other stimuli depending on the cellular contexts. Recent lines of evidence have shown that EndoMT is involved in various steps of tumor progression, including tumor angiogenesis, intravasation and extravasation of cancer cells, formation of cancer-associated fibroblasts, and cancer therapy resistance. In this review, we summarize current updates on EndoMT, highlight the roles of EndoMT in tumor progression and metastasis, and underline targeting EndoMT as a potential therapeutic strategy.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer therapy resistance, EMT, EndoMT, Metastasis, TGF-β, Tumor angiogenesis, Tumor microenvironment
in
Seminars in Cancer Biology
volume
92
pages
9 pages
publisher
Academic Press
external identifiers
  • pmid:37068553
  • scopus:85153287776
ISSN
1044-579X
DOI
10.1016/j.semcancer.2023.04.007
language
English
LU publication?
yes
id
5614e63d-2166-4543-a82f-067f851c0508
date added to LUP
2023-06-12 15:26:33
date last changed
2024-04-19 23:50:03
@article{5614e63d-2166-4543-a82f-067f851c0508,
  abstract     = {{<p>Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known as endothelial-mesenchymal transition (EndoMT). This plasticity of ECs is mediated by various cytokines, including transforming growth factor-β (TGF-β), and modulated by other stimuli depending on the cellular contexts. Recent lines of evidence have shown that EndoMT is involved in various steps of tumor progression, including tumor angiogenesis, intravasation and extravasation of cancer cells, formation of cancer-associated fibroblasts, and cancer therapy resistance. In this review, we summarize current updates on EndoMT, highlight the roles of EndoMT in tumor progression and metastasis, and underline targeting EndoMT as a potential therapeutic strategy.</p>}},
  author       = {{Watabe, Tetsuro and Takahashi, Kazuki and Pietras, Kristian and Yoshimatsu, Yasuhiro}},
  issn         = {{1044-579X}},
  keywords     = {{Cancer therapy resistance; EMT; EndoMT; Metastasis; TGF-β; Tumor angiogenesis; Tumor microenvironment}},
  language     = {{eng}},
  pages        = {{130--138}},
  publisher    = {{Academic Press}},
  series       = {{Seminars in Cancer Biology}},
  title        = {{Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system}},
  url          = {{http://dx.doi.org/10.1016/j.semcancer.2023.04.007}},
  doi          = {{10.1016/j.semcancer.2023.04.007}},
  volume       = {{92}},
  year         = {{2023}},
}