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Deliveries after malignant disease before pregnancy : Maternal characteristics, pregnancy, and delivery complications

Rad, Zahra Sabeti LU ; Friberg, Britt LU ; Henic, Emir LU ; Rylander, Lars LU ; Ståhl, Olof LU ; Källén, Bengt LU and Lingman, Göran LU (2016) In Journal of Adolescent and Young Adult Oncology 5(3). p.240-247
Abstract

Purpose: Survival after cancer has increased, and the question of risks in later pregnancies has become important. A previous malignancy may affect pregnancy outcome. Methods: Comparison of women with malignant disease before pregnancy with all other women giving birth during 1994-2011. Data were obtained by linkage between Swedish national health registers. Subfertility, evaluated as time to pregnancy, and in vitro fertilization (IVF) before the relevant delivery were studied. The following delivery diagnoses were studied: gestational diabetes, preeclampsia, placenta previa, placenta abruption, placenta retention, bleeding around delivery, and premature rupture of membranes. The rates of cesarean section and vacuum extraction or... (More)

Purpose: Survival after cancer has increased, and the question of risks in later pregnancies has become important. A previous malignancy may affect pregnancy outcome. Methods: Comparison of women with malignant disease before pregnancy with all other women giving birth during 1994-2011. Data were obtained by linkage between Swedish national health registers. Subfertility, evaluated as time to pregnancy, and in vitro fertilization (IVF) before the relevant delivery were studied. The following delivery diagnoses were studied: gestational diabetes, preeclampsia, placenta previa, placenta abruption, placenta retention, bleeding around delivery, and premature rupture of membranes. The rates of cesarean section and vacuum extraction or forceps delivery were also studied. Results: We identified 3931 women with 7176 deliveries and with a malignancy diagnosed at least 1 year before the delivery. The total number of deliveries in Sweden in these years was 1,746,870. Overall, an increased risk of subfertility (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.07-1.28), use of IVF (OR = 1.36, CI 1.21-1.53), delivery complications (OR = 1.17, 95% CI 1.10-1.24), and rate of caesarean sections (OR = 1.27, 95% CI 1.20-1.34) was observed among women with a history of malignancy compared with other women. Conclusion: We found an increased risk of subfertility, pregnancy, and delivery complications in women with a history of malignant disease. Further studies are needed to evaluate the risks of specific treatments and to provide these women with reliable information that could affect their family planning.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
delivery complications, IVF, malignant disease, pregnancy complications, subfertility
in
Journal of Adolescent and Young Adult Oncology
volume
5
issue
3
pages
8 pages
publisher
Mary Ann Liebert Inc.
external identifiers
  • scopus:85000789212
  • wos:000385342800006
ISSN
2156-5333
DOI
10.1089/jayao.2016.0008
language
English
LU publication?
yes
id
5618d757-72d0-4a80-9ac4-60a161eaa2a6
date added to LUP
2016-12-20 14:09:36
date last changed
2017-10-29 04:55:48
@article{5618d757-72d0-4a80-9ac4-60a161eaa2a6,
  abstract     = {<p>Purpose: Survival after cancer has increased, and the question of risks in later pregnancies has become important. A previous malignancy may affect pregnancy outcome. Methods: Comparison of women with malignant disease before pregnancy with all other women giving birth during 1994-2011. Data were obtained by linkage between Swedish national health registers. Subfertility, evaluated as time to pregnancy, and in vitro fertilization (IVF) before the relevant delivery were studied. The following delivery diagnoses were studied: gestational diabetes, preeclampsia, placenta previa, placenta abruption, placenta retention, bleeding around delivery, and premature rupture of membranes. The rates of cesarean section and vacuum extraction or forceps delivery were also studied. Results: We identified 3931 women with 7176 deliveries and with a malignancy diagnosed at least 1 year before the delivery. The total number of deliveries in Sweden in these years was 1,746,870. Overall, an increased risk of subfertility (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.07-1.28), use of IVF (OR = 1.36, CI 1.21-1.53), delivery complications (OR = 1.17, 95% CI 1.10-1.24), and rate of caesarean sections (OR = 1.27, 95% CI 1.20-1.34) was observed among women with a history of malignancy compared with other women. Conclusion: We found an increased risk of subfertility, pregnancy, and delivery complications in women with a history of malignant disease. Further studies are needed to evaluate the risks of specific treatments and to provide these women with reliable information that could affect their family planning.</p>},
  author       = {Rad, Zahra Sabeti and Friberg, Britt and Henic, Emir and Rylander, Lars and Ståhl, Olof and Källén, Bengt and Lingman, Göran},
  issn         = {2156-5333},
  keyword      = {delivery complications,IVF,malignant disease,pregnancy complications,subfertility},
  language     = {eng},
  month        = {09},
  number       = {3},
  pages        = {240--247},
  publisher    = {Mary Ann Liebert Inc.},
  series       = {Journal of Adolescent and Young Adult Oncology},
  title        = {Deliveries after malignant disease before pregnancy : Maternal characteristics, pregnancy, and delivery complications},
  url          = {http://dx.doi.org/10.1089/jayao.2016.0008},
  volume       = {5},
  year         = {2016},
}