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Risks of Depression and Suicide After Diagnosis With Heart Failure : A National Cohort Study

Crump, Casey LU ; Sundquist, Jan LU ; Kendler, Kenneth S. ; Sieh, Weiva ; Edwards, Alexis C. LU and Sundquist, Kristina LU (2022) In JACC: Heart Failure 10(11). p.819-827
Abstract

Background: Heart failure (HF) has been associated with psychosocial distress, but other long-term mental health sequelae are unclear. Objectives: In this study, the authors sought to determine risks of major depression and suicide, susceptible time periods, and sex-specific differences after HF diagnosis in a large population-based cohort. Methods: A national cohort study was conducted of all 154,572 persons diagnosed with HF at ages 18-75 years during 2002-2017 in Sweden and 1,545,720 age- and sex-matched population-based control subjects who were followed up for major depression and suicide ascertained from nationwide inpatient, outpatient, and death records through 2018. Poisson regression was used to compute incidence rate ratios... (More)

Background: Heart failure (HF) has been associated with psychosocial distress, but other long-term mental health sequelae are unclear. Objectives: In this study, the authors sought to determine risks of major depression and suicide, susceptible time periods, and sex-specific differences after HF diagnosis in a large population-based cohort. Methods: A national cohort study was conducted of all 154,572 persons diagnosed with HF at ages 18-75 years during 2002-2017 in Sweden and 1,545,720 age- and sex-matched population-based control subjects who were followed up for major depression and suicide ascertained from nationwide inpatient, outpatient, and death records through 2018. Poisson regression was used to compute incidence rate ratios (IRRs) while adjusting for sociodemographic factors and comorbidities. Results: HF was associated with increased risks of major depression and death by suicide in both men and women, with highest risks in the first 3 months, then declining to modest risks at ≥12 months after HF diagnosis. Within 3 months after HF diagnosis, adjusted IRRs for new-onset major depression were 3.34 (95% CI: 3.04-3.68) in men and 2.78 (95% CI: 2.51-3.09) in women, and for suicide death were 4.47 (95% CI: 2.62-7.62) in men and 2.82 (95% CI: 1.11-7.12) in women. These risks were elevated regardless of age at HF diagnosis. HF was associated with significantly more depression cases in women (P < 0.001). Conclusions: In this large national cohort, HF was associated with substantially increased risks of depression and suicide in men and women, with highest risks occurring within 3 months after HF diagnosis. Men and women with HF need timely detection and treatment of depression and suicidality.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular diseases, depression, heart failure, suicide
in
JACC: Heart Failure
volume
10
issue
11
pages
9 pages
publisher
Elsevier
external identifiers
  • pmid:36328649
  • scopus:85140249225
ISSN
2213-1779
DOI
10.1016/j.jchf.2022.07.007
language
English
LU publication?
yes
id
562996cf-97fc-4f9b-9b3a-8f2211899183
date added to LUP
2022-12-13 11:32:19
date last changed
2024-04-18 16:20:16
@article{562996cf-97fc-4f9b-9b3a-8f2211899183,
  abstract     = {{<p>Background: Heart failure (HF) has been associated with psychosocial distress, but other long-term mental health sequelae are unclear. Objectives: In this study, the authors sought to determine risks of major depression and suicide, susceptible time periods, and sex-specific differences after HF diagnosis in a large population-based cohort. Methods: A national cohort study was conducted of all 154,572 persons diagnosed with HF at ages 18-75 years during 2002-2017 in Sweden and 1,545,720 age- and sex-matched population-based control subjects who were followed up for major depression and suicide ascertained from nationwide inpatient, outpatient, and death records through 2018. Poisson regression was used to compute incidence rate ratios (IRRs) while adjusting for sociodemographic factors and comorbidities. Results: HF was associated with increased risks of major depression and death by suicide in both men and women, with highest risks in the first 3 months, then declining to modest risks at ≥12 months after HF diagnosis. Within 3 months after HF diagnosis, adjusted IRRs for new-onset major depression were 3.34 (95% CI: 3.04-3.68) in men and 2.78 (95% CI: 2.51-3.09) in women, and for suicide death were 4.47 (95% CI: 2.62-7.62) in men and 2.82 (95% CI: 1.11-7.12) in women. These risks were elevated regardless of age at HF diagnosis. HF was associated with significantly more depression cases in women (P &lt; 0.001). Conclusions: In this large national cohort, HF was associated with substantially increased risks of depression and suicide in men and women, with highest risks occurring within 3 months after HF diagnosis. Men and women with HF need timely detection and treatment of depression and suicidality.</p>}},
  author       = {{Crump, Casey and Sundquist, Jan and Kendler, Kenneth S. and Sieh, Weiva and Edwards, Alexis C. and Sundquist, Kristina}},
  issn         = {{2213-1779}},
  keywords     = {{cardiovascular diseases; depression; heart failure; suicide}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{819--827}},
  publisher    = {{Elsevier}},
  series       = {{JACC: Heart Failure}},
  title        = {{Risks of Depression and Suicide After Diagnosis With Heart Failure : A National Cohort Study}},
  url          = {{http://dx.doi.org/10.1016/j.jchf.2022.07.007}},
  doi          = {{10.1016/j.jchf.2022.07.007}},
  volume       = {{10}},
  year         = {{2022}},
}