Advanced

Angels and demons: neurotrophic factors and epilepsy

Simonato, Michele; Tongiorgi, Enrico and Kokaia, Merab LU (2006) In Trends in Pharmacological Sciences 27(12). p.631-638
Abstract
Several lines of evidence indicate that neurotrophic factors (NTFs) could be key causal mediators in the development of acquired epileptic syndromes. Yet the trophic properties of NTFs indicate that they might be used to treat epilepsy-associated damage. Accordingly, different NTFs, or even the same NTF, could produce functionally contrasting effects in the context of epilepsy. Recent experimental evidence begins to shed light on the mechanisms underlying these contrasting effects. Understanding these mechanisms will be instrumental for the development of effective therapies, which must be based on a careful consideration of the biological properties of NTFs. Here, we critically evaluate new information emerging in this area and discuss... (More)
Several lines of evidence indicate that neurotrophic factors (NTFs) could be key causal mediators in the development of acquired epileptic syndromes. Yet the trophic properties of NTFs indicate that they might be used to treat epilepsy-associated damage. Accordingly, different NTFs, or even the same NTF, could produce functionally contrasting effects in the context of epilepsy. Recent experimental evidence begins to shed light on the mechanisms underlying these contrasting effects. Understanding these mechanisms will be instrumental for the development of effective therapies, which must be based on a careful consideration of the biological properties of NTFs. Here, we critically evaluate new information emerging in this area and discuss its implications for clinical treatment. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Pharmacological Sciences
volume
27
issue
12
pages
631 - 638
publisher
Elsevier
external identifiers
  • wos:000242680400005
  • scopus:33750937896
ISSN
0165-6147
DOI
10.1016/j.tips.2006.10.002
language
English
LU publication?
yes
id
5652f52e-44dc-42e5-96b4-aceaffdd96b4 (old id 683543)
date added to LUP
2008-01-03 15:54:05
date last changed
2019-10-13 04:16:33
@article{5652f52e-44dc-42e5-96b4-aceaffdd96b4,
  abstract     = {Several lines of evidence indicate that neurotrophic factors (NTFs) could be key causal mediators in the development of acquired epileptic syndromes. Yet the trophic properties of NTFs indicate that they might be used to treat epilepsy-associated damage. Accordingly, different NTFs, or even the same NTF, could produce functionally contrasting effects in the context of epilepsy. Recent experimental evidence begins to shed light on the mechanisms underlying these contrasting effects. Understanding these mechanisms will be instrumental for the development of effective therapies, which must be based on a careful consideration of the biological properties of NTFs. Here, we critically evaluate new information emerging in this area and discuss its implications for clinical treatment.},
  author       = {Simonato, Michele and Tongiorgi, Enrico and Kokaia, Merab},
  issn         = {0165-6147},
  language     = {eng},
  number       = {12},
  pages        = {631--638},
  publisher    = {Elsevier},
  series       = {Trends in Pharmacological Sciences},
  title        = {Angels and demons: neurotrophic factors and epilepsy},
  url          = {http://dx.doi.org/10.1016/j.tips.2006.10.002},
  volume       = {27},
  year         = {2006},
}