Angels and demons: neurotrophic factors and epilepsy
(2006) In Trends in Pharmacological Sciences 27(12). p.631-638- Abstract
- Several lines of evidence indicate that neurotrophic factors (NTFs) could be key causal mediators in the development of acquired epileptic syndromes. Yet the trophic properties of NTFs indicate that they might be used to treat epilepsy-associated damage. Accordingly, different NTFs, or even the same NTF, could produce functionally contrasting effects in the context of epilepsy. Recent experimental evidence begins to shed light on the mechanisms underlying these contrasting effects. Understanding these mechanisms will be instrumental for the development of effective therapies, which must be based on a careful consideration of the biological properties of NTFs. Here, we critically evaluate new information emerging in this area and discuss... (More)
- Several lines of evidence indicate that neurotrophic factors (NTFs) could be key causal mediators in the development of acquired epileptic syndromes. Yet the trophic properties of NTFs indicate that they might be used to treat epilepsy-associated damage. Accordingly, different NTFs, or even the same NTF, could produce functionally contrasting effects in the context of epilepsy. Recent experimental evidence begins to shed light on the mechanisms underlying these contrasting effects. Understanding these mechanisms will be instrumental for the development of effective therapies, which must be based on a careful consideration of the biological properties of NTFs. Here, we critically evaluate new information emerging in this area and discuss its implications for clinical treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/683543
- author
- Simonato, Michele ; Tongiorgi, Enrico and Kokaia, Merab LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Pharmacological Sciences
- volume
- 27
- issue
- 12
- pages
- 631 - 638
- publisher
- Elsevier
- external identifiers
-
- wos:000242680400005
- scopus:33750937896
- ISSN
- 0165-6147
- DOI
- 10.1016/j.tips.2006.10.002
- language
- English
- LU publication?
- yes
- id
- 5652f52e-44dc-42e5-96b4-aceaffdd96b4 (old id 683543)
- date added to LUP
- 2016-04-01 16:52:53
- date last changed
- 2022-03-22 21:46:22
@article{5652f52e-44dc-42e5-96b4-aceaffdd96b4,
abstract = {{Several lines of evidence indicate that neurotrophic factors (NTFs) could be key causal mediators in the development of acquired epileptic syndromes. Yet the trophic properties of NTFs indicate that they might be used to treat epilepsy-associated damage. Accordingly, different NTFs, or even the same NTF, could produce functionally contrasting effects in the context of epilepsy. Recent experimental evidence begins to shed light on the mechanisms underlying these contrasting effects. Understanding these mechanisms will be instrumental for the development of effective therapies, which must be based on a careful consideration of the biological properties of NTFs. Here, we critically evaluate new information emerging in this area and discuss its implications for clinical treatment.}},
author = {{Simonato, Michele and Tongiorgi, Enrico and Kokaia, Merab}},
issn = {{0165-6147}},
language = {{eng}},
number = {{12}},
pages = {{631--638}},
publisher = {{Elsevier}},
series = {{Trends in Pharmacological Sciences}},
title = {{Angels and demons: neurotrophic factors and epilepsy}},
url = {{http://dx.doi.org/10.1016/j.tips.2006.10.002}},
doi = {{10.1016/j.tips.2006.10.002}},
volume = {{27}},
year = {{2006}},
}