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Automatic T2* determination for quantification of iron load in heart and liver : a comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods

Hedström, Erik LU ; Voigt, Tobias; Greil, Gerald; Schaeffter, Tobias and Nagel, Eike (2017) In Clinical Physiology and Functional Imaging2002-01-01+01:00 37(3). p.299-304
Abstract

PURPOSE: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients.

METHODS: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm(3) , 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference.

RESULTS: Phantoms: MLE showed low variability between NSA1... (More)

PURPOSE: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients.

METHODS: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm(3) , 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference.

RESULTS: Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: <0·31 ms, CI < ±0·35 ms).

PATIENTS: No differences were found between methods in heart (MLE versus all: <-0·22 ms, CI < ±0·75 ms) or liver (MLE versus all: <0·12 ms, CI < ±0·26 ms).

CONCLUSIONS: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.

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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
37
issue
3
pages
299 - 304
publisher
Wiley Online Library
external identifiers
  • scopus:84983121061
ISSN
1475-0961
DOI
10.1111/cpf.12303
language
English
LU publication?
no
id
56791212-7861-45dc-82d9-0999acb68596
date added to LUP
2017-02-02 11:41:10
date last changed
2018-01-07 11:47:47
@article{56791212-7861-45dc-82d9-0999acb68596,
  abstract     = {<p>PURPOSE: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients.</p><p>METHODS: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm(3) , 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference.</p><p>RESULTS: Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: &lt;0·31 ms, CI &lt; ±0·35 ms).</p><p>PATIENTS: No differences were found between methods in heart (MLE versus all: &lt;-0·22 ms, CI &lt; ±0·75 ms) or liver (MLE versus all: &lt;0·12 ms, CI &lt; ±0·26 ms).</p><p>CONCLUSIONS: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.</p>},
  author       = {Hedström, Erik and Voigt, Tobias and Greil, Gerald and Schaeffter, Tobias and Nagel, Eike},
  issn         = {1475-0961},
  language     = {eng},
  number       = {3},
  pages        = {299--304},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Automatic T2* determination for quantification of iron load in heart and liver : a comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods},
  url          = {http://dx.doi.org/10.1111/cpf.12303},
  volume       = {37},
  year         = {2017},
}