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Continuous separation of cells and particles in microfluidic systems

Lenshof, Andreas LU and Laurell, Thomas LU (2010) In Chemical Society Reviews 39(3). p.1203-1217
Abstract
The progress in microfabrication and lab-on-a-chip technologies has been a major area of development for new approaches to bioanalytics and integrated concepts for cell biology. Fundamental advances in the development of elastomer based microfluidics have been driving factors for making microfluidic technology available to a larger scientific community in the past years. In line with this, microfluidic separation of cells and particles is currently developing rapidly where key areas of interest are found in designing lab-on-a-chip systems that offer controlled microenvironments for studies of fundamental cell biology. More recently industrial interests are seen in the development of micro chip based flow cytometry technology both for... (More)
The progress in microfabrication and lab-on-a-chip technologies has been a major area of development for new approaches to bioanalytics and integrated concepts for cell biology. Fundamental advances in the development of elastomer based microfluidics have been driving factors for making microfluidic technology available to a larger scientific community in the past years. In line with this, microfluidic separation of cells and particles is currently developing rapidly where key areas of interest are found in designing lab-on-a-chip systems that offer controlled microenvironments for studies of fundamental cell biology. More recently industrial interests are seen in the development of micro chip based flow cytometry technology both for preclinical research and clinical diagnostics. This critical review outlines the most recent developments in microfluidic technology for cell and particle separation in continuous flow based systems. (130 references) (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemical Society Reviews
volume
39
issue
3
pages
1203 - 1217
publisher
Royal Society of Chemistry
external identifiers
  • wos:000274920300021
  • pmid:20179832
  • scopus:77952472317
ISSN
0306-0012
DOI
10.1039/b915999c
language
English
LU publication?
yes
id
57220614-476a-4bf4-870e-24c23b1b18bc (old id 1568302)
date added to LUP
2010-03-18 11:32:40
date last changed
2018-10-21 03:02:23
@article{57220614-476a-4bf4-870e-24c23b1b18bc,
  abstract     = {The progress in microfabrication and lab-on-a-chip technologies has been a major area of development for new approaches to bioanalytics and integrated concepts for cell biology. Fundamental advances in the development of elastomer based microfluidics have been driving factors for making microfluidic technology available to a larger scientific community in the past years. In line with this, microfluidic separation of cells and particles is currently developing rapidly where key areas of interest are found in designing lab-on-a-chip systems that offer controlled microenvironments for studies of fundamental cell biology. More recently industrial interests are seen in the development of micro chip based flow cytometry technology both for preclinical research and clinical diagnostics. This critical review outlines the most recent developments in microfluidic technology for cell and particle separation in continuous flow based systems. (130 references)},
  author       = {Lenshof, Andreas and Laurell, Thomas},
  issn         = {0306-0012},
  language     = {eng},
  number       = {3},
  pages        = {1203--1217},
  publisher    = {Royal Society of Chemistry},
  series       = {Chemical Society Reviews},
  title        = {Continuous separation of cells and particles in microfluidic systems},
  url          = {http://dx.doi.org/10.1039/b915999c},
  volume       = {39},
  year         = {2010},
}