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Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk : A population-based study in Swedish cohorts

Arage, Getachew ; Dekkers, Koen F. ; Rašo, Luka Marko ; Hammar, Ulf ; Ericson, Ulrika LU ; Larsson, Susanna C. ; Engel, Hanna ; Baldanzi, Gabriel LU ; Pertiwi, Kamalita and Sayols-Baixeras, Sergi , et al. (2025) In Metabolism: Clinical and Experimental 168.
Abstract

Background: Higher meat intake has been associated with adverse health outcomes, including cardiovascular disease (CVD). This study investigated plasma metabolites associated with meat intake and their relation with cardiometabolic biomarkers, subclinical CVD markers, and incident CVD. Methods: Associations between self-reported meat intake and 1272 plasma metabolites were investigated in the SCAPIS cohort (n = 8,819; ages 50–64). Meat-associated metabolites were further examined for relation with subclinical CVD markers in the POEM cohort (n = 502; age 50) and incident CVD in the EpiHealth cohort (n = 2,278; ages 45–75; 107 incident cases over 9.6 years follow-up). Meat intake was categorized into white, unprocessed red, and processed... (More)

Background: Higher meat intake has been associated with adverse health outcomes, including cardiovascular disease (CVD). This study investigated plasma metabolites associated with meat intake and their relation with cardiometabolic biomarkers, subclinical CVD markers, and incident CVD. Methods: Associations between self-reported meat intake and 1272 plasma metabolites were investigated in the SCAPIS cohort (n = 8,819; ages 50–64). Meat-associated metabolites were further examined for relation with subclinical CVD markers in the POEM cohort (n = 502; age 50) and incident CVD in the EpiHealth cohort (n = 2,278; ages 45–75; 107 incident cases over 9.6 years follow-up). Meat intake was categorized into white, unprocessed red, and processed red meat. Linear regression analyzed associations between meat intake, metabolites and cardiometabolic biomarkers, and subclinical CVD markers, while Cox models evaluated association between meat-associated metabolites and incident CVD. Results: After correction for multiple testing, 458, 368, and 403 metabolites were associated with white, unprocessed red, and processed red meat, respectively. Processed red meat-associated metabolites were associated with higher levels of fasting insulin, hemoglobin A1c, and lipoprotein(a), and were inversely associated with maximal oxygen consumption. Two metabolites, 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) (hazard ratios (HR: 1.32; 95 % CI: 1.08, 1.62)) and glutamine degradant (HR: 1.35; 95 % CI: 1.07, 1.72), that were inversely associated with intake of all meat types, were also associated with a higher risk of incident CVD. Conclusions: This study provides comprehensive analysis of self-reported meat intake and plasma metabolites. The findings may enhance our understanding of the relationship between meat intake and CVD, and provide insights into underlying mechanisms.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular Disease, Meat intake, Plasma metabolomics, Population-based epidemiological study
in
Metabolism: Clinical and Experimental
volume
168
article number
156188
publisher
Elsevier
external identifiers
  • pmid:40081615
  • scopus:105002489301
ISSN
0026-0495
DOI
10.1016/j.metabol.2025.156188
language
English
LU publication?
yes
id
572c0fdb-9e18-4ac7-b5bc-25bf66e940b9
date added to LUP
2025-08-06 10:18:49
date last changed
2025-08-06 10:57:00
@article{572c0fdb-9e18-4ac7-b5bc-25bf66e940b9,
  abstract     = {{<p>Background: Higher meat intake has been associated with adverse health outcomes, including cardiovascular disease (CVD). This study investigated plasma metabolites associated with meat intake and their relation with cardiometabolic biomarkers, subclinical CVD markers, and incident CVD. Methods: Associations between self-reported meat intake and 1272 plasma metabolites were investigated in the SCAPIS cohort (n = 8,819; ages 50–64). Meat-associated metabolites were further examined for relation with subclinical CVD markers in the POEM cohort (n = 502; age 50) and incident CVD in the EpiHealth cohort (n = 2,278; ages 45–75; 107 incident cases over 9.6 years follow-up). Meat intake was categorized into white, unprocessed red, and processed red meat. Linear regression analyzed associations between meat intake, metabolites and cardiometabolic biomarkers, and subclinical CVD markers, while Cox models evaluated association between meat-associated metabolites and incident CVD. Results: After correction for multiple testing, 458, 368, and 403 metabolites were associated with white, unprocessed red, and processed red meat, respectively. Processed red meat-associated metabolites were associated with higher levels of fasting insulin, hemoglobin A1c, and lipoprotein(a), and were inversely associated with maximal oxygen consumption. Two metabolites, 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) (hazard ratios (HR: 1.32; 95 % CI: 1.08, 1.62)) and glutamine degradant (HR: 1.35; 95 % CI: 1.07, 1.72), that were inversely associated with intake of all meat types, were also associated with a higher risk of incident CVD. Conclusions: This study provides comprehensive analysis of self-reported meat intake and plasma metabolites. The findings may enhance our understanding of the relationship between meat intake and CVD, and provide insights into underlying mechanisms.</p>}},
  author       = {{Arage, Getachew and Dekkers, Koen F. and Rašo, Luka Marko and Hammar, Ulf and Ericson, Ulrika and Larsson, Susanna C. and Engel, Hanna and Baldanzi, Gabriel and Pertiwi, Kamalita and Sayols-Baixeras, Sergi and Landberg, Rikard and Sundström, Johan and Smith, J. Gustav and Engström, Gunnar and Ärnlöv, Johan and Orho-Melander, Marju and Lind, Lars and Fall, Tove and Ahmad, Shafqat}},
  issn         = {{0026-0495}},
  keywords     = {{Cardiovascular Disease; Meat intake; Plasma metabolomics; Population-based epidemiological study}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Metabolism: Clinical and Experimental}},
  title        = {{Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk : A population-based study in Swedish cohorts}},
  url          = {{http://dx.doi.org/10.1016/j.metabol.2025.156188}},
  doi          = {{10.1016/j.metabol.2025.156188}},
  volume       = {{168}},
  year         = {{2025}},
}