Antioxidant and anti-inflammatory effects of Urtica pilulifera extracts in type2 diabetic rats
(2013) In Journal of Ethnopharmacology 145(1). p.269-277- Abstract
- Ethnopharmacological relevance: "Urtica pilulifera has been traditionally used in Egyptian system as an herbal remedy to be a diuretic, antiasthmatic, anti-inflammatory, hypoglycemic, hemostatic, antidandruff and astringent" Aim of the study: To evaluate the potential effects of ethyl acetate (EA), chloroform (CHLOR) and hexane (HEXA) extracts of Urtica piluliferaas oral anti-diabetic agents as well as to evaluate their possible antioxidant and anti-inflammatory effects in type2 diabetic rat model. Material and methods: Type2 diabetes was induced by a high fat diet and low dose streptozotocin (STZ). Diabetic adult male albino rats were allocated into groups and treated according to the following schedule; Pioglitazone HCL (PIO), EA, CHLOR... (More)
- Ethnopharmacological relevance: "Urtica pilulifera has been traditionally used in Egyptian system as an herbal remedy to be a diuretic, antiasthmatic, anti-inflammatory, hypoglycemic, hemostatic, antidandruff and astringent" Aim of the study: To evaluate the potential effects of ethyl acetate (EA), chloroform (CHLOR) and hexane (HEXA) extracts of Urtica piluliferaas oral anti-diabetic agents as well as to evaluate their possible antioxidant and anti-inflammatory effects in type2 diabetic rat model. Material and methods: Type2 diabetes was induced by a high fat diet and low dose streptozotocin (STZ). Diabetic adult male albino rats were allocated into groups and treated according to the following schedule; Pioglitazone HCL (PIO), EA, CHLOR and HEXA extracts of Urtica piluilifera at two doses of 250 and 500 mg/ kg were used. In addition, a normal control group and a diabetic control one were used for comparison. Blood glucose, insulin resistance, antioxidant enzymes, 8-hydroxy-2-deoxyguanosine (8-OHdG) as well as C-reactive protein and tumor necrosis factor-a levels were evaluated. Results: EA and CHLOR extracts of Urtica pilulifera exhibited a significant hypoglycemia associated with antioxidant and anti-inflammatory effects in diabetic rats; however, HEXA extract showed no beneficial effect. These activities are responsible, at least partly, for improvements that have been seen in hyperglycemia and insulin resistance of diabetic rats. Conclusion: Our results encourage the traditional use of Urtica pilulifera extract as an antioxidant and anti-inflammatory agent as an additional therapy of diabetes. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3470615
- author
- Abo-elmatty, Dina M. ; Essawy, Soha S. ; Badr, Jihan M. and Sterner, Olov LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Urtica pilulifera, Diabetes, Streptozotocin, Rat
- in
- Journal of Ethnopharmacology
- volume
- 145
- issue
- 1
- pages
- 269 - 277
- publisher
- Elsevier
- external identifiers
-
- wos:000313604800035
- scopus:84871288018
- ISSN
- 1872-7573
- DOI
- 10.1016/j.jep.2012.11.002
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 57ac6f9a-0521-4841-9ecb-6248b8e0b93c (old id 3470615)
- date added to LUP
- 2016-04-01 10:25:34
- date last changed
- 2022-04-12 06:11:23
@article{57ac6f9a-0521-4841-9ecb-6248b8e0b93c,
abstract = {{Ethnopharmacological relevance: "Urtica pilulifera has been traditionally used in Egyptian system as an herbal remedy to be a diuretic, antiasthmatic, anti-inflammatory, hypoglycemic, hemostatic, antidandruff and astringent" Aim of the study: To evaluate the potential effects of ethyl acetate (EA), chloroform (CHLOR) and hexane (HEXA) extracts of Urtica piluliferaas oral anti-diabetic agents as well as to evaluate their possible antioxidant and anti-inflammatory effects in type2 diabetic rat model. Material and methods: Type2 diabetes was induced by a high fat diet and low dose streptozotocin (STZ). Diabetic adult male albino rats were allocated into groups and treated according to the following schedule; Pioglitazone HCL (PIO), EA, CHLOR and HEXA extracts of Urtica piluilifera at two doses of 250 and 500 mg/ kg were used. In addition, a normal control group and a diabetic control one were used for comparison. Blood glucose, insulin resistance, antioxidant enzymes, 8-hydroxy-2-deoxyguanosine (8-OHdG) as well as C-reactive protein and tumor necrosis factor-a levels were evaluated. Results: EA and CHLOR extracts of Urtica pilulifera exhibited a significant hypoglycemia associated with antioxidant and anti-inflammatory effects in diabetic rats; however, HEXA extract showed no beneficial effect. These activities are responsible, at least partly, for improvements that have been seen in hyperglycemia and insulin resistance of diabetic rats. Conclusion: Our results encourage the traditional use of Urtica pilulifera extract as an antioxidant and anti-inflammatory agent as an additional therapy of diabetes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.}},
author = {{Abo-elmatty, Dina M. and Essawy, Soha S. and Badr, Jihan M. and Sterner, Olov}},
issn = {{1872-7573}},
keywords = {{Urtica pilulifera; Diabetes; Streptozotocin; Rat}},
language = {{eng}},
number = {{1}},
pages = {{269--277}},
publisher = {{Elsevier}},
series = {{Journal of Ethnopharmacology}},
title = {{Antioxidant and anti-inflammatory effects of Urtica pilulifera extracts in type2 diabetic rats}},
url = {{http://dx.doi.org/10.1016/j.jep.2012.11.002}},
doi = {{10.1016/j.jep.2012.11.002}},
volume = {{145}},
year = {{2013}},
}