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γ-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis

Tossman, Ulf ; Wieloch, Tadeusz LU and Ungerstedt, Urban (1985) In Neuroscience Letters 62(2). p.231-235
Abstract

Extracellular levels of striatal γ-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric period. The results demonstrate that events associated with the onset of isoelectricity during hypoglycemia trigger an increase in extracellular concentrations of GABA and taurine. The discrepancy in time-course of these changes may reflect differences in compartmentation, function and metabolism of the two amino acids.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
extracellular concentration, hypoglycemia, microdialysis, rat, taurine, γ-aminobutyric acid
in
Neuroscience Letters
volume
62
issue
2
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:4088534
  • scopus:0022368111
ISSN
0304-3940
DOI
10.1016/0304-3940(85)90360-X
language
English
LU publication?
yes
id
57c075e8-98ae-4c30-b9ae-185c46d8adf2
date added to LUP
2019-06-13 17:48:14
date last changed
2021-01-03 09:10:58
@article{57c075e8-98ae-4c30-b9ae-185c46d8adf2,
  abstract     = {<p>Extracellular levels of striatal γ-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric period. The results demonstrate that events associated with the onset of isoelectricity during hypoglycemia trigger an increase in extracellular concentrations of GABA and taurine. The discrepancy in time-course of these changes may reflect differences in compartmentation, function and metabolism of the two amino acids.</p>},
  author       = {Tossman, Ulf and Wieloch, Tadeusz and Ungerstedt, Urban},
  issn         = {0304-3940},
  language     = {eng},
  month        = {12},
  number       = {2},
  pages        = {231--235},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {γ-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis},
  url          = {http://dx.doi.org/10.1016/0304-3940(85)90360-X},
  doi          = {10.1016/0304-3940(85)90360-X},
  volume       = {62},
  year         = {1985},
}