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GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.

Rehn, Martin LU ; Krarup, Peter-Martin ; Christensen, Lise H ; Seidelin, Jakob B ; Ågren, Magnus S and Syk, Ingvar LU (2015) In Surgical Infections 16(6). p.702-708
Abstract
Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Surgical Infections
volume
16
issue
6
pages
702 - 708
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:26171681
  • wos:000365530800007
  • scopus:84948694543
  • pmid:26171681
ISSN
1557-8674
DOI
10.1089/sur.2014.248
language
English
LU publication?
yes
id
57f868cc-4c35-489b-b705-91f746c1f445 (old id 7744557)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26171681?dopt=Abstract
date added to LUP
2016-04-01 11:14:29
date last changed
2022-04-05 01:07:13
@article{57f868cc-4c35-489b-b705-91f746c1f445,
  abstract     = {{Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.}},
  author       = {{Rehn, Martin and Krarup, Peter-Martin and Christensen, Lise H and Seidelin, Jakob B and Ågren, Magnus S and Syk, Ingvar}},
  issn         = {{1557-8674}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{702--708}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Surgical Infections}},
  title        = {{GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.}},
  url          = {{http://dx.doi.org/10.1089/sur.2014.248}},
  doi          = {{10.1089/sur.2014.248}},
  volume       = {{16}},
  year         = {{2015}},
}