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''Sponge" nanoparticle dispersions in aqueous mixtures of diglycerol monooleate, glycerol dioleate, and polysorbate 80

Barauskas, Justas LU ; Misiunas, Audrius LU ; Gunnarsson, Torsten; Tiberg, Fredrik LU and Johnsson, Markus LU (2006) In Langmuir 22(14). p.6328-6334
Abstract
Lipid nanoparticles of nonlamellar lyotropic phases have a wide solubilizing and encapsulating spectrum for a range of substances thanks to their nanostructured interior featuring both lipophilic and hydrophilic domains. As a consequence, these systems have emerged as promising drug delivery systems in various pharmaceutical and diagnostic applications. Here we present the phase behavior and dispersion properties of a novel three-component lipid system composed of diglycerol monooleate (DGMO), glycerol dioleate (GDO), and polysorbate 80 (P80) which shows several advantageous features relating to drug delivery applications including: spontaneous dispersion formation with a narrow size distribution and tunable particle phase-structure. The... (More)
Lipid nanoparticles of nonlamellar lyotropic phases have a wide solubilizing and encapsulating spectrum for a range of substances thanks to their nanostructured interior featuring both lipophilic and hydrophilic domains. As a consequence, these systems have emerged as promising drug delivery systems in various pharmaceutical and diagnostic applications. Here we present the phase behavior and dispersion properties of a novel three-component lipid system composed of diglycerol monooleate (DGMO), glycerol dioleate (GDO), and polysorbate 80 (P80) which shows several advantageous features relating to drug delivery applications including: spontaneous dispersion formation with a narrow size distribution and tunable particle phase-structure. The obtained phase diagram shows the presence of lamellar (L-alpha), hexagonal (H-2), and reverse bicontinuous cubic (V-2) liquid crystalline phases and an inverse micellar (L-2) solution. A particularly interesting observation is the presence of a phase region where two liquid phases coexist, most likely the L-2 and L-3 ("sponge phase"). These two phase structures appear also to coexist in the submicron particles formed in the dilute water region, where the L-3 element appears to stabilize nanoparticles with inner L-2 structure. Increasing the fraction of the dispersing P80 component results in the growth of the more water rich L-3 "surface phase" at the expense of the size of the inner L-2 core. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
22
issue
14
pages
6328 - 6334
publisher
The American Chemical Society
external identifiers
  • wos:000238558500051
  • scopus:33746550283
ISSN
0743-7463
DOI
10.1021/la060295f
language
English
LU publication?
yes
id
585b006b-76dd-425a-9c29-cb5712a33152 (old id 404831)
date added to LUP
2007-09-25 13:34:45
date last changed
2019-04-10 01:54:17
@article{585b006b-76dd-425a-9c29-cb5712a33152,
  abstract     = {Lipid nanoparticles of nonlamellar lyotropic phases have a wide solubilizing and encapsulating spectrum for a range of substances thanks to their nanostructured interior featuring both lipophilic and hydrophilic domains. As a consequence, these systems have emerged as promising drug delivery systems in various pharmaceutical and diagnostic applications. Here we present the phase behavior and dispersion properties of a novel three-component lipid system composed of diglycerol monooleate (DGMO), glycerol dioleate (GDO), and polysorbate 80 (P80) which shows several advantageous features relating to drug delivery applications including: spontaneous dispersion formation with a narrow size distribution and tunable particle phase-structure. The obtained phase diagram shows the presence of lamellar (L-alpha), hexagonal (H-2), and reverse bicontinuous cubic (V-2) liquid crystalline phases and an inverse micellar (L-2) solution. A particularly interesting observation is the presence of a phase region where two liquid phases coexist, most likely the L-2 and L-3 ("sponge phase"). These two phase structures appear also to coexist in the submicron particles formed in the dilute water region, where the L-3 element appears to stabilize nanoparticles with inner L-2 structure. Increasing the fraction of the dispersing P80 component results in the growth of the more water rich L-3 "surface phase" at the expense of the size of the inner L-2 core.},
  author       = {Barauskas, Justas and Misiunas, Audrius and Gunnarsson, Torsten and Tiberg, Fredrik and Johnsson, Markus},
  issn         = {0743-7463},
  language     = {eng},
  number       = {14},
  pages        = {6328--6334},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {''Sponge" nanoparticle dispersions in aqueous mixtures of diglycerol monooleate, glycerol dioleate, and polysorbate 80},
  url          = {http://dx.doi.org/10.1021/la060295f},
  volume       = {22},
  year         = {2006},
}