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Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation

Nogal, Ana ; Asnicar, Francesco ; Vijay, Amrita ; Kouraki, Afroditi ; Visconti, Alessia ; Louca, Panayiotis ; Wong, Kari ; Baleanu, Andrei Florin ; Giordano, Francesca and Wolf, Jonathan , et al. (2023) In Gut microbes 15(1).
Abstract

Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and trauma patients. We report low concordance between circulating and fecal SCFAs, significant postprandial changes in most circulating SCFAs, and a heritable genetic component (average h2 : serum = 14%(SD = 14%); stool = 12%(SD = 6%)). Furthermore, we find that gut microbiome can accurately predict their fecal levels (AUC>0.71)... (More)

Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and trauma patients. We report low concordance between circulating and fecal SCFAs, significant postprandial changes in most circulating SCFAs, and a heritable genetic component (average h2 : serum = 14%(SD = 14%); stool = 12%(SD = 6%)). Furthermore, we find that gut microbiome can accurately predict their fecal levels (AUC>0.71) while presenting weaker associations with serum. Finally, we report different correlation patterns with inflammatory markers depending on the type of inflammatory response (chronic or acute trauma). Our results illustrate the breadth of the physiological relevance of SCFAs on human inflammatory and metabolic responses highlighting the need for a deeper understanding of this important class of molecules.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gut microbiota, heritability, inflammatory response, postprandial, Short-chain fatty acids
in
Gut microbes
volume
15
issue
1
article number
2240050
publisher
Taylor & Francis
external identifiers
  • pmid:37526398
  • scopus:85166069357
ISSN
1949-0976
DOI
10.1080/19490976.2023.2240050
language
English
LU publication?
yes
id
58cac4cb-97b7-4a48-9a89-19eeac23548b
date added to LUP
2023-11-21 13:32:55
date last changed
2024-04-18 16:46:05
@article{58cac4cb-97b7-4a48-9a89-19eeac23548b,
  abstract     = {{<p>Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and trauma patients. We report low concordance between circulating and fecal SCFAs, significant postprandial changes in most circulating SCFAs, and a heritable genetic component (average h<sup>2</sup> : serum = 14%(SD = 14%); stool = 12%(SD = 6%)). Furthermore, we find that gut microbiome can accurately predict their fecal levels (AUC&gt;0.71) while presenting weaker associations with serum. Finally, we report different correlation patterns with inflammatory markers depending on the type of inflammatory response (chronic or acute trauma). Our results illustrate the breadth of the physiological relevance of SCFAs on human inflammatory and metabolic responses highlighting the need for a deeper understanding of this important class of molecules.</p>}},
  author       = {{Nogal, Ana and Asnicar, Francesco and Vijay, Amrita and Kouraki, Afroditi and Visconti, Alessia and Louca, Panayiotis and Wong, Kari and Baleanu, Andrei Florin and Giordano, Francesca and Wolf, Jonathan and Hadjigeorgiou, George and Davies, Richard and Michelotti, Gregory A. and Franks, Paul W. and Berry, Sarah E. and Falchi, Mario and Ikram, Adeel and Ollivere, Benjamin J. and Zheng, Amy and Nightingale, Jessica and Mangino, Massimo and Segata, Nicola and Bulsiewicz, William J. and Spector, Tim D. and Valdes, Ana M. and Menni, Cristina}},
  issn         = {{1949-0976}},
  keywords     = {{gut microbiota; heritability; inflammatory response; postprandial; Short-chain fatty acids}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Taylor & Francis}},
  series       = {{Gut microbes}},
  title        = {{Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation}},
  url          = {{http://dx.doi.org/10.1080/19490976.2023.2240050}},
  doi          = {{10.1080/19490976.2023.2240050}},
  volume       = {{15}},
  year         = {{2023}},
}