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Mitochondria and cell death

Van Aken, Olivier LU (2017) p.343-371
Abstract

This chapter discusses the current body of evidence that supports a role for mitochondria in plant cell death. In plants, a reduction of mitochondrial function and adenosine triphosphate (ATP) levels by suppression of autophagy triggered necrosis instead of developmental programmed cell death (PCD). PCD is found to be closely associated with mitochondrial reactive oxygen species (mtROS) production in plants. A key mechanism of PCD in animal systems is the excessive swelling of mitochondria; a phenomenon termed the mitochondrial permeability transition (mPT). Mitochondria are known to trigger nuclear gene expression of stress-related genes and significant evidence points towards a role for ROS in getting signals out of the mitochondria.... (More)

This chapter discusses the current body of evidence that supports a role for mitochondria in plant cell death. In plants, a reduction of mitochondrial function and adenosine triphosphate (ATP) levels by suppression of autophagy triggered necrosis instead of developmental programmed cell death (PCD). PCD is found to be closely associated with mitochondrial reactive oxygen species (mtROS) production in plants. A key mechanism of PCD in animal systems is the excessive swelling of mitochondria; a phenomenon termed the mitochondrial permeability transition (mPT). Mitochondria are known to trigger nuclear gene expression of stress-related genes and significant evidence points towards a role for ROS in getting signals out of the mitochondria. Many pro- and antiapoptotic proteins that are associated with mitochondria were identified in non-plant systems, and a push in the plant field was initiated to find out how much of this mitochondrial pathway is conserved. Plant mitochondria become an increasingly important metabolic hub during developmental leaf senescence.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Autophagy, Developmental leaf senescence, Mitochondrial permeability transition pore, Mitochondrial programmed cell death pathway conservation, Mitochondrial reactive oxygen species role
host publication
Annual Plant Reviews, Volume 50
pages
29 pages
publisher
Interscience Wiley
external identifiers
  • scopus:85049180305
ISBN
9781118906576
9781118906583
language
English
LU publication?
yes
id
58d34754-7e24-4485-b2d0-376e5b635410
date added to LUP
2018-07-19 12:08:49
date last changed
2019-02-20 11:22:32
@inbook{58d34754-7e24-4485-b2d0-376e5b635410,
  abstract     = {<p>This chapter discusses the current body of evidence that supports a role for mitochondria in plant cell death. In plants, a reduction of mitochondrial function and adenosine triphosphate (ATP) levels by suppression of autophagy triggered necrosis instead of developmental programmed cell death (PCD). PCD is found to be closely associated with mitochondrial reactive oxygen species (mtROS) production in plants. A key mechanism of PCD in animal systems is the excessive swelling of mitochondria; a phenomenon termed the mitochondrial permeability transition (mPT). Mitochondria are known to trigger nuclear gene expression of stress-related genes and significant evidence points towards a role for ROS in getting signals out of the mitochondria. Many pro- and antiapoptotic proteins that are associated with mitochondria were identified in non-plant systems, and a push in the plant field was initiated to find out how much of this mitochondrial pathway is conserved. Plant mitochondria become an increasingly important metabolic hub during developmental leaf senescence.</p>},
  author       = {Van Aken, Olivier},
  isbn         = {9781118906576},
  keyword      = {Autophagy,Developmental leaf senescence,Mitochondrial permeability transition pore,Mitochondrial programmed cell death pathway conservation,Mitochondrial reactive oxygen species role},
  language     = {eng},
  month        = {01},
  pages        = {343--371},
  publisher    = {Interscience Wiley},
  title        = {Mitochondria and cell death},
  year         = {2017},
}