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Work disability in newly diagnosed patients with primary sjögren syndrome

Mandl, Thomas LU ; Jorgensen, Tanja Schjodt; Skougaard, Marie; Olsson, Peter LU and Kristensen, Lars Erik LU (2017) In Journal of Rheumatology 44(2). p.209-215
Abstract

Objective. To study longterm work disability and possible predictors in newly diagnosed patients with primary Sjogren syndrome (pSS). Methods. Because we wanted to include only patients with full work availability potential, eligible patients were aged 18-62 years. Fifty-one patients (mean age 46 yrs, range 18-61 yrs, 50 women) diagnosed with pSS between January 2001 and December 2012 were included in the study. For each patient we randomly selected 4 reference subjects from the general population and matched for age, sex, and area of residence. We linked data to the Swedish Social Insurance Agency and calculated the proportion as well as net days of work disability in 30-day intervals from 12 months before pSS diagnosis until 24 months... (More)

Objective. To study longterm work disability and possible predictors in newly diagnosed patients with primary Sjogren syndrome (pSS). Methods. Because we wanted to include only patients with full work availability potential, eligible patients were aged 18-62 years. Fifty-one patients (mean age 46 yrs, range 18-61 yrs, 50 women) diagnosed with pSS between January 2001 and December 2012 were included in the study. For each patient we randomly selected 4 reference subjects from the general population and matched for age, sex, and area of residence. We linked data to the Swedish Social Insurance Agency and calculated the proportion as well as net days of work disability in 30-day intervals from 12 months before pSS diagnosis until 24 months after . Results. Work disability was increased in patients with pSS in comparison to general population comparators. At diagnosis, 26% of patients were work-disabled, while 37% and 41% were disabled at 12 and 24 months after diagnosis, respectively (p < 0.05 and p < 0.05 vs baseline). Prior work disability status at diagnosis (OR 15.4, 95% CI 2.9-81.9; p = 0.001), concomitant fibromyalgia (OR 10.5, 95% CI 2.0-56.0; p = 0.006), and each additional year of age (OR 1.1, 95% CI 1.0-1.2; p = 0.009) were found to be associated with work disability 24 months after diagnosis. Conclusion. Patients with pSS showed an increased work disability, in comparison with the general population, which increased significantly during the first 2 years after diagnosis. Work disability at diagnosis, concomitant fibromyalgia, and increasing age, but not anti-SSA/anti-SSB antibodies or disease activity, were associated with longterm work disability.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Primary sjogren syndrome, Work disability
in
Journal of Rheumatology
volume
44
issue
2
pages
7 pages
publisher
J Rheumatol Publ Co
external identifiers
  • scopus:85011715999
  • wos:000393909300013
ISSN
0315-162X
DOI
10.3899/jrheum.160932
language
English
LU publication?
yes
id
58ee68ea-9db0-4512-a37d-0566a1663c92
date added to LUP
2017-02-20 10:14:02
date last changed
2018-01-07 11:51:04
@article{58ee68ea-9db0-4512-a37d-0566a1663c92,
  abstract     = {<p>Objective. To study longterm work disability and possible predictors in newly diagnosed patients with primary Sjogren syndrome (pSS). Methods. Because we wanted to include only patients with full work availability potential, eligible patients were aged 18-62 years. Fifty-one patients (mean age 46 yrs, range 18-61 yrs, 50 women) diagnosed with pSS between January 2001 and December 2012 were included in the study. For each patient we randomly selected 4 reference subjects from the general population and matched for age, sex, and area of residence. We linked data to the Swedish Social Insurance Agency and calculated the proportion as well as net days of work disability in 30-day intervals from 12 months before pSS diagnosis until 24 months after . Results. Work disability was increased in patients with pSS in comparison to general population comparators. At diagnosis, 26% of patients were work-disabled, while 37% and 41% were disabled at 12 and 24 months after diagnosis, respectively (p &lt; 0.05 and p &lt; 0.05 vs baseline). Prior work disability status at diagnosis (OR 15.4, 95% CI 2.9-81.9; p = 0.001), concomitant fibromyalgia (OR 10.5, 95% CI 2.0-56.0; p = 0.006), and each additional year of age (OR 1.1, 95% CI 1.0-1.2; p = 0.009) were found to be associated with work disability 24 months after diagnosis. Conclusion. Patients with pSS showed an increased work disability, in comparison with the general population, which increased significantly during the first 2 years after diagnosis. Work disability at diagnosis, concomitant fibromyalgia, and increasing age, but not anti-SSA/anti-SSB antibodies or disease activity, were associated with longterm work disability.</p>},
  author       = {Mandl, Thomas and Jorgensen, Tanja Schjodt and Skougaard, Marie and Olsson, Peter and Kristensen, Lars Erik},
  issn         = {0315-162X},
  keyword      = {Primary sjogren syndrome,Work disability},
  language     = {eng},
  month        = {02},
  number       = {2},
  pages        = {209--215},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {Work disability in newly diagnosed patients with primary sjögren syndrome},
  url          = {http://dx.doi.org/10.3899/jrheum.160932},
  volume       = {44},
  year         = {2017},
}