Clinical features of registry-ascertained alcohol use disorders that reflect familial risk
(2016) In Drug and Alcohol Dependence 164. p.135-142- Abstract
Background: Alcohol Use Disorder (AUD) is clinically heterogeneous. Using a large epidemiological sample ascertained via public registries, is it possible to identify clinical and historical features of AUD that reflect familial risk? Methods: Using registration in national medical, legal or pharmacy registries, we identified four kinds of relative pairs (n = 683,223) starting with a proband with AUD: cousins, half-siblings, full-siblings and monozygotic cotwins. Using linear hazard regression, we examined the interaction between five clinical/historical features of AUD in the proband and risk for AUD in these relatives. Results: Increased risk for AUD in relatives was predicted by the proband's early age at first registration, total... (More)
Background: Alcohol Use Disorder (AUD) is clinically heterogeneous. Using a large epidemiological sample ascertained via public registries, is it possible to identify clinical and historical features of AUD that reflect familial risk? Methods: Using registration in national medical, legal or pharmacy registries, we identified four kinds of relative pairs (n = 683,223) starting with a proband with AUD: cousins, half-siblings, full-siblings and monozygotic cotwins. Using linear hazard regression, we examined the interaction between five clinical/historical features of AUD in the proband and risk for AUD in these relatives. Results: Increased risk for AUD in relatives was predicted by the proband's early age at first registration, total number of registrations, recurrence, history of drug abuse and ascertainment in the medical versus the legal or pharmacy registry. In multivariate models, age at first registration, number of registrations, recurrence and history of drug abuse remained significant and in aggregate strongly predicted the risk for AUD in relatives. The risk for AUD in siblings of AUD probands in the highest decile of genetic risk predicted by these four indices was more than twice as great as that predicted in siblings of probands in the lowest risk decile. Conclusions: In an epidemiological sample, familial risk for AUD can be assessed by simple clinical and historical variables.
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- author
- Kendler, Kenneth S. ; Ohlsson, Henrik LU ; Edwards, Alexis C. ; Karriker-Jaffe, Katherine J. ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2016-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Age at onset, Alcohol use disorder, Familial risk, Number of registrations
- in
- Drug and Alcohol Dependence
- volume
- 164
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84971350992
- wos:000378468800018
- pmid:27234657
- ISSN
- 0376-8716
- DOI
- 10.1016/j.drugalcdep.2016.05.003
- language
- English
- LU publication?
- yes
- id
- 58f5c16c-be72-4d63-8680-694662dac019
- date added to LUP
- 2016-06-16 13:56:44
- date last changed
- 2024-04-05 02:13:48
@article{58f5c16c-be72-4d63-8680-694662dac019,
abstract = {{<p>Background: Alcohol Use Disorder (AUD) is clinically heterogeneous. Using a large epidemiological sample ascertained via public registries, is it possible to identify clinical and historical features of AUD that reflect familial risk? Methods: Using registration in national medical, legal or pharmacy registries, we identified four kinds of relative pairs (n = 683,223) starting with a proband with AUD: cousins, half-siblings, full-siblings and monozygotic cotwins. Using linear hazard regression, we examined the interaction between five clinical/historical features of AUD in the proband and risk for AUD in these relatives. Results: Increased risk for AUD in relatives was predicted by the proband's early age at first registration, total number of registrations, recurrence, history of drug abuse and ascertainment in the medical versus the legal or pharmacy registry. In multivariate models, age at first registration, number of registrations, recurrence and history of drug abuse remained significant and in aggregate strongly predicted the risk for AUD in relatives. The risk for AUD in siblings of AUD probands in the highest decile of genetic risk predicted by these four indices was more than twice as great as that predicted in siblings of probands in the lowest risk decile. Conclusions: In an epidemiological sample, familial risk for AUD can be assessed by simple clinical and historical variables.</p>}},
author = {{Kendler, Kenneth S. and Ohlsson, Henrik and Edwards, Alexis C. and Karriker-Jaffe, Katherine J. and Sundquist, Jan and Sundquist, Kristina}},
issn = {{0376-8716}},
keywords = {{Age at onset; Alcohol use disorder; Familial risk; Number of registrations}},
language = {{eng}},
month = {{07}},
pages = {{135--142}},
publisher = {{Elsevier}},
series = {{Drug and Alcohol Dependence}},
title = {{Clinical features of registry-ascertained alcohol use disorders that reflect familial risk}},
url = {{http://dx.doi.org/10.1016/j.drugalcdep.2016.05.003}},
doi = {{10.1016/j.drugalcdep.2016.05.003}},
volume = {{164}},
year = {{2016}},
}