Advanced

Clinical features of registry-ascertained alcohol use disorders that reflect familial risk

Kendler, Kenneth S.; Ohlsson, Henrik LU ; Edwards, Alexis C.; Karriker-Jaffe, Katherine J.; Sundquist, Jan LU and Sundquist, Kristina LU (2016) In Drug and Alcohol Dependence 164. p.135-142
Abstract

Background: Alcohol Use Disorder (AUD) is clinically heterogeneous. Using a large epidemiological sample ascertained via public registries, is it possible to identify clinical and historical features of AUD that reflect familial risk? Methods: Using registration in national medical, legal or pharmacy registries, we identified four kinds of relative pairs (n = 683,223) starting with a proband with AUD: cousins, half-siblings, full-siblings and monozygotic cotwins. Using linear hazard regression, we examined the interaction between five clinical/historical features of AUD in the proband and risk for AUD in these relatives. Results: Increased risk for AUD in relatives was predicted by the proband's early age at first registration, total... (More)

Background: Alcohol Use Disorder (AUD) is clinically heterogeneous. Using a large epidemiological sample ascertained via public registries, is it possible to identify clinical and historical features of AUD that reflect familial risk? Methods: Using registration in national medical, legal or pharmacy registries, we identified four kinds of relative pairs (n = 683,223) starting with a proband with AUD: cousins, half-siblings, full-siblings and monozygotic cotwins. Using linear hazard regression, we examined the interaction between five clinical/historical features of AUD in the proband and risk for AUD in these relatives. Results: Increased risk for AUD in relatives was predicted by the proband's early age at first registration, total number of registrations, recurrence, history of drug abuse and ascertainment in the medical versus the legal or pharmacy registry. In multivariate models, age at first registration, number of registrations, recurrence and history of drug abuse remained significant and in aggregate strongly predicted the risk for AUD in relatives. The risk for AUD in siblings of AUD probands in the highest decile of genetic risk predicted by these four indices was more than twice as great as that predicted in siblings of probands in the lowest risk decile. Conclusions: In an epidemiological sample, familial risk for AUD can be assessed by simple clinical and historical variables.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age at onset, Alcohol use disorder, Familial risk, Number of registrations
in
Drug and Alcohol Dependence
volume
164
pages
8 pages
publisher
Elsevier
external identifiers
  • Scopus:84971350992
  • WOS:000378468800018
ISSN
0376-8716
DOI
10.1016/j.drugalcdep.2016.05.003
language
English
LU publication?
yes
id
58f5c16c-be72-4d63-8680-694662dac019
date added to LUP
2016-06-16 13:56:44
date last changed
2017-01-01 08:28:11
@article{58f5c16c-be72-4d63-8680-694662dac019,
  abstract     = {<p>Background: Alcohol Use Disorder (AUD) is clinically heterogeneous. Using a large epidemiological sample ascertained via public registries, is it possible to identify clinical and historical features of AUD that reflect familial risk? Methods: Using registration in national medical, legal or pharmacy registries, we identified four kinds of relative pairs (n = 683,223) starting with a proband with AUD: cousins, half-siblings, full-siblings and monozygotic cotwins. Using linear hazard regression, we examined the interaction between five clinical/historical features of AUD in the proband and risk for AUD in these relatives. Results: Increased risk for AUD in relatives was predicted by the proband's early age at first registration, total number of registrations, recurrence, history of drug abuse and ascertainment in the medical versus the legal or pharmacy registry. In multivariate models, age at first registration, number of registrations, recurrence and history of drug abuse remained significant and in aggregate strongly predicted the risk for AUD in relatives. The risk for AUD in siblings of AUD probands in the highest decile of genetic risk predicted by these four indices was more than twice as great as that predicted in siblings of probands in the lowest risk decile. Conclusions: In an epidemiological sample, familial risk for AUD can be assessed by simple clinical and historical variables.</p>},
  author       = {Kendler, Kenneth S. and Ohlsson, Henrik and Edwards, Alexis C. and Karriker-Jaffe, Katherine J. and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0376-8716},
  keyword      = {Age at onset,Alcohol use disorder,Familial risk,Number of registrations},
  language     = {eng},
  month        = {07},
  pages        = {135--142},
  publisher    = {Elsevier},
  series       = {Drug and Alcohol Dependence},
  title        = {Clinical features of registry-ascertained alcohol use disorders that reflect familial risk},
  url          = {http://dx.doi.org/10.1016/j.drugalcdep.2016.05.003},
  volume       = {164},
  year         = {2016},
}