Cytidine deaminase activity in synovial fluid of patients with rheumatoid arthritis: relation to lactoferrin, acidosis, and cartilage proteoglycan release
Månsson, Bengt LU
; Geborek, Pierre
LU
; Saxne, Tore
LU
and Björnsson, Sven
LU
(1990)
In Annals of the Rheumatic Diseases
49(8).
p.594-597
- Abstract
- It is claimed that cytidine deaminase activity reflects local granulocyte turnover or activity in the synovial fluid of patients with rheumatoid arthritis, but cytidine deaminase is not a granulocyte specific enzyme. Lactoferrin is a granulocyte specific protein that is released from the secondary granulae during activation. We measured cytidine deaminase activity and lactoferrin concentrations in 33 rheumatic synovial fluid samples. Cytidine deaminase activity and lactoferrin concentrations correlated closely, indicating that both analyses reflect similar events in the joint-that is, result in their release from granulocytes. Cytidine deaminase activity and granulocyte concentrations correlated less closely, suggesting that there are... (More)
- It is claimed that cytidine deaminase activity reflects local granulocyte turnover or activity in the synovial fluid of patients with rheumatoid arthritis, but cytidine deaminase is not a granulocyte specific enzyme. Lactoferrin is a granulocyte specific protein that is released from the secondary granulae during activation. We measured cytidine deaminase activity and lactoferrin concentrations in 33 rheumatic synovial fluid samples. Cytidine deaminase activity and lactoferrin concentrations correlated closely, indicating that both analyses reflect similar events in the joint-that is, result in their release from granulocytes. Cytidine deaminase activity and granulocyte concentrations correlated less closely, suggesting that there are additional factors besides the cell number which contribute to this release. Joint acidosis may be one such factor, as pH and cytidine deaminase activity correlated inversely. There was no association with synovial fluid proteoglycan concentrations, a marker of cartilage degradation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105389
- author
- Månsson, Bengt
LU
; Geborek, Pierre
LU
; Saxne, Tore
LU
and Björnsson, Sven
LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of the Rheumatic Diseases
- volume
- 49
- issue
- 8
- pages
- 594 - 597
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:2396864
- scopus:0025350514
- ISSN
- 1468-2060
- DOI
- 10.1136/ard.49.8.594
- language
- English
- LU publication?
- yes
- id
- 5991d616-4f5a-453d-aae4-de8cb3b8919f (old id 1105389)
- alternative location
- http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1004171&blobtype=pdf
- date added to LUP
- 2016-04-01 16:13:10
- date last changed
- 2021-08-22 03:32:20
@article{5991d616-4f5a-453d-aae4-de8cb3b8919f,
abstract = {{It is claimed that cytidine deaminase activity reflects local granulocyte turnover or activity in the synovial fluid of patients with rheumatoid arthritis, but cytidine deaminase is not a granulocyte specific enzyme. Lactoferrin is a granulocyte specific protein that is released from the secondary granulae during activation. We measured cytidine deaminase activity and lactoferrin concentrations in 33 rheumatic synovial fluid samples. Cytidine deaminase activity and lactoferrin concentrations correlated closely, indicating that both analyses reflect similar events in the joint-that is, result in their release from granulocytes. Cytidine deaminase activity and granulocyte concentrations correlated less closely, suggesting that there are additional factors besides the cell number which contribute to this release. Joint acidosis may be one such factor, as pH and cytidine deaminase activity correlated inversely. There was no association with synovial fluid proteoglycan concentrations, a marker of cartilage degradation.}},
author = {{Månsson, Bengt and Geborek, Pierre and Saxne, Tore and Björnsson, Sven}},
issn = {{1468-2060}},
language = {{eng}},
number = {{8}},
pages = {{594--597}},
publisher = {{BMJ Publishing Group}},
series = {{Annals of the Rheumatic Diseases}},
title = {{Cytidine deaminase activity in synovial fluid of patients with rheumatoid arthritis: relation to lactoferrin, acidosis, and cartilage proteoglycan release}},
url = {{http://dx.doi.org/10.1136/ard.49.8.594}},
doi = {{10.1136/ard.49.8.594}},
volume = {{49}},
year = {{1990}},
}