Long-term outcome of the Surgisis® (Biodesign®) anal fistula plug for complex cryptoglandular and Crohn’s fistulas
Aho Fält, Ursula LU
; Zawadzki, Antoni
LU
; Starck, Marianne
LU
; Bohe, Måns
LU
and Johnson, Louis B.
LU
(2021)
In Colorectal Disease
23(1).
p.178-185
- Abstract
Aim: To evaluate the long-term success rate of treatment with the Surgisis® (Biodesign®) anal fistula plug for complex anal fistulas, assess fistula plug failure over time and compare success rates for fistula plug between a group of patients with cryptoglandular fistula and another group with Crohn's fistula. Method: This is a single-centre study of consecutive patients treated with the Surgisis® (Biodesign®) anal fistula plug between May 2006 and October 2009. All patients had complex anal fistulas in need of surgical treatment. The patients were assessed preoperatively by physical examination and three-dimensional (3D) endoanal ultrasound, and treated with a loose seton. Postoperative... (More)
Aim: To evaluate the long-term success rate of treatment with the Surgisis® (Biodesign®) anal fistula plug for complex anal fistulas, assess fistula plug failure over time and compare success rates for fistula plug between a group of patients with cryptoglandular fistula and another group with Crohn's fistula. Method: This is a single-centre study of consecutive patients treated with the Surgisis® (Biodesign®) anal fistula plug between May 2006 and October 2009. All patients had complex anal fistulas in need of surgical treatment. The patients were assessed preoperatively by physical examination and three-dimensional (3D) endoanal ultrasound, and treated with a loose seton. Postoperative assessment by clinical examination and 3D endoanal ultrasound was performed at 2 weeks, 3 months and 6–12 months. Long-term follow-up was carried out in 2017 using a questionnaire, and clinical examination combined with 3D endoanal ultrasound was performed if the questionnaire indicated any signs of fistula recurrence. Results: A total of 95 patients were included; 30 had quiescent Crohn's disease. Overall, 151 plug procedures were performed. Long-term follow-up was undertaken in 90 (95%) patients; the results showed that after a median period of 110 months, the overall healing rate after one to five plug procedures was 38%. No statistically significant difference in success rate was found between the cryptoglandular fistula group and the Crohn's fistula group (P = 0.37). No further healing was observed after the use of three plugs. Conclusion: Considering its low morbidity in a complex disease with high recurrence rates over time, the anal fistula plug may still be considered as one of the first-line treatments for patients with complex anal fistulas.
(Less)
- author
- Aho Fält, Ursula
LU
; Zawadzki, Antoni
LU
; Starck, Marianne
LU
; Bohe, Måns
LU
and Johnson, Louis B.
LU
- organization
- publishing date
- 2021-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anal fistula plug, Complex anal fistula, Crohn's disease
- in
- Colorectal Disease
- volume
- 23
- issue
- 1
- pages
- 178 - 185
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:33155391
- scopus:85098069161
- ISSN
- 1462-8910
- DOI
- 10.1111/codi.15429
- project
- Anal fistulae - Three-dimensional endoanal ultrasound and outcomes of collagen plug treatment
- Treatment of complex anal fistulas
- language
- English
- LU publication?
- yes
- id
- 59a6e189-4e8b-4b8c-8b62-2a720d51145c
- date added to LUP
- 2021-01-08 10:36:45
- date last changed
- 2024-06-13 03:41:06
@article{59a6e189-4e8b-4b8c-8b62-2a720d51145c,
abstract = {{<p>Aim: To evaluate the long-term success rate of treatment with the Surgisis<sup>®</sup> (Biodesign<sup>®</sup>) anal fistula plug for complex anal fistulas, assess fistula plug failure over time and compare success rates for fistula plug between a group of patients with cryptoglandular fistula and another group with Crohn's fistula. Method: This is a single-centre study of consecutive patients treated with the Surgisis<sup>®</sup> (Biodesign<sup>®</sup>) anal fistula plug between May 2006 and October 2009. All patients had complex anal fistulas in need of surgical treatment. The patients were assessed preoperatively by physical examination and three-dimensional (3D) endoanal ultrasound, and treated with a loose seton. Postoperative assessment by clinical examination and 3D endoanal ultrasound was performed at 2 weeks, 3 months and 6–12 months. Long-term follow-up was carried out in 2017 using a questionnaire, and clinical examination combined with 3D endoanal ultrasound was performed if the questionnaire indicated any signs of fistula recurrence. Results: A total of 95 patients were included; 30 had quiescent Crohn's disease. Overall, 151 plug procedures were performed. Long-term follow-up was undertaken in 90 (95%) patients; the results showed that after a median period of 110 months, the overall healing rate after one to five plug procedures was 38%. No statistically significant difference in success rate was found between the cryptoglandular fistula group and the Crohn's fistula group (P = 0.37). No further healing was observed after the use of three plugs. Conclusion: Considering its low morbidity in a complex disease with high recurrence rates over time, the anal fistula plug may still be considered as one of the first-line treatments for patients with complex anal fistulas.</p>}},
author = {{Aho Fält, Ursula and Zawadzki, Antoni and Starck, Marianne and Bohe, Måns and Johnson, Louis B.}},
issn = {{1462-8910}},
keywords = {{anal fistula plug; Complex anal fistula; Crohn's disease}},
language = {{eng}},
number = {{1}},
pages = {{178--185}},
publisher = {{Wiley-Blackwell}},
series = {{Colorectal Disease}},
title = {{Long-term outcome of the Surgisis<sup>®</sup> (Biodesign<sup>®</sup>) anal fistula plug for complex cryptoglandular and Crohn’s fistulas}},
url = {{http://dx.doi.org/10.1111/codi.15429}},
doi = {{10.1111/codi.15429}},
volume = {{23}},
year = {{2021}},
}