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Diagnostic evaluation of three cardiac software packages using a consecutive group of patients

Johansson, Lena LU ; Lomsky, Milan; Marving, Jens; Ohlsson, Mattias LU ; Svensson, Sven-Eric and Edenbrandt, Lars LU (2011) In EJNMMI Research 1(1). p.1-7
Abstract

Purpose: The aim of this study was to compare the diagnostic performance of the three software packages 4DMSPECT (4DM), Emory Cardiac Toolbox (ECTb), and Cedars Quantitative Perfusion SPECT (QPS) for quantification of myocardial perfusion scintigram (MPS) using a large group of consecutive patients. Methods: We studied 1,052 consecutive patients who underwent 2-day stress/rest 99mTc-sestamibi MPS studies. The reference/gold-standard classifications for the MPS studies were obtained from three physicians, with more than 25 years each of experience in nuclear cardiology, who re-evaluated all MPS images. Automatic processing was carried out using 4DM, ECTb, and QPS software packages. Total stress defect extent (TDE) and summed stress score... (More)

Purpose: The aim of this study was to compare the diagnostic performance of the three software packages 4DMSPECT (4DM), Emory Cardiac Toolbox (ECTb), and Cedars Quantitative Perfusion SPECT (QPS) for quantification of myocardial perfusion scintigram (MPS) using a large group of consecutive patients. Methods: We studied 1,052 consecutive patients who underwent 2-day stress/rest 99mTc-sestamibi MPS studies. The reference/gold-standard classifications for the MPS studies were obtained from three physicians, with more than 25 years each of experience in nuclear cardiology, who re-evaluated all MPS images. Automatic processing was carried out using 4DM, ECTb, and QPS software packages. Total stress defect extent (TDE) and summed stress score (SSS) based on a 17-segment model were obtained from the software packages. Receiver-operating characteristic (ROC) analysis was performed. Results: A total of 734 patients were classified as normal and the remaining 318 were classified as having infarction and/or ischemia. The performance of the software packages calculated as the area under the SSS ROC curve were 0.87 for 4DM, 0.80 for QPS, and 0.76 for ECTb (QPS vs. ECTb p = 0.03; other differences p < 0.0001). The area under the TDE ROC curve were 0.87 for 4DM, 0.82 for QPS, and 0.76 for ECTb (QPS vs. ECTb p = 0.0005; other differences p < 0.0001). Conclusion: There are considerable differences in performance between the three software packages with 4DM showing the best performance and ECTb the worst. These differences in performance should be taken in consideration when software packages are used in clinical routine or in clinical studies.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Automatic quantification, Coronary artery disease, Myocardial perfusion imaging, Software, SPECT
in
EJNMMI Research
volume
1
issue
1
pages
7 pages
publisher
BioMed Central
external identifiers
  • scopus:84875912203
ISSN
2191-219X
DOI
10.1186/2191-219X-1-22
language
English
LU publication?
yes
id
59c6933e-dee0-490e-84d5-ab13de1b7865
date added to LUP
2017-05-17 08:13:12
date last changed
2017-05-22 09:41:25
@article{59c6933e-dee0-490e-84d5-ab13de1b7865,
  abstract     = {<p>Purpose: The aim of this study was to compare the diagnostic performance of the three software packages 4DMSPECT (4DM), Emory Cardiac Toolbox (ECTb), and Cedars Quantitative Perfusion SPECT (QPS) for quantification of myocardial perfusion scintigram (MPS) using a large group of consecutive patients. Methods: We studied 1,052 consecutive patients who underwent 2-day stress/rest 99mTc-sestamibi MPS studies. The reference/gold-standard classifications for the MPS studies were obtained from three physicians, with more than 25 years each of experience in nuclear cardiology, who re-evaluated all MPS images. Automatic processing was carried out using 4DM, ECTb, and QPS software packages. Total stress defect extent (TDE) and summed stress score (SSS) based on a 17-segment model were obtained from the software packages. Receiver-operating characteristic (ROC) analysis was performed. Results: A total of 734 patients were classified as normal and the remaining 318 were classified as having infarction and/or ischemia. The performance of the software packages calculated as the area under the SSS ROC curve were 0.87 for 4DM, 0.80 for QPS, and 0.76 for ECTb (QPS vs. ECTb p = 0.03; other differences p &lt; 0.0001). The area under the TDE ROC curve were 0.87 for 4DM, 0.82 for QPS, and 0.76 for ECTb (QPS vs. ECTb p = 0.0005; other differences p &lt; 0.0001). Conclusion: There are considerable differences in performance between the three software packages with 4DM showing the best performance and ECTb the worst. These differences in performance should be taken in consideration when software packages are used in clinical routine or in clinical studies.</p>},
  author       = {Johansson, Lena and Lomsky, Milan and Marving, Jens and Ohlsson, Mattias and Svensson, Sven-Eric and Edenbrandt, Lars},
  issn         = {2191-219X},
  keyword      = {Automatic quantification,Coronary artery disease,Myocardial perfusion imaging,Software,SPECT},
  language     = {eng},
  number       = {1},
  pages        = {1--7},
  publisher    = {BioMed Central},
  series       = {EJNMMI Research},
  title        = {Diagnostic evaluation of three cardiac software packages using a consecutive group of patients},
  url          = {http://dx.doi.org/10.1186/2191-219X-1-22},
  volume       = {1},
  year         = {2011},
}