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Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

Banerjee, Jennifer J. ; Aerne, Birgit L. ; Holder, Maxine V. ; Hauri, Simon LU ; Gstaiger, Matthias and Tapon, Nicolas (2017) In eLife 6.
Abstract

Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates.... (More)

Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
eLife
volume
6
article number
e25014
publisher
eLife Sciences Publications
external identifiers
  • pmid:28665270
  • wos:000404592700001
  • scopus:85022319467
ISSN
2050-084X
DOI
10.7554/eLife.25014
language
English
LU publication?
yes
id
59f3da3f-9e51-4709-8cdd-12cf2c06440c
date added to LUP
2017-08-09 15:14:13
date last changed
2025-01-07 18:24:53
@article{59f3da3f-9e51-4709-8cdd-12cf2c06440c,
  abstract     = {{<p>Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.</p>}},
  author       = {{Banerjee, Jennifer J. and Aerne, Birgit L. and Holder, Maxine V. and Hauri, Simon and Gstaiger, Matthias and Tapon, Nicolas}},
  issn         = {{2050-084X}},
  language     = {{eng}},
  month        = {{06}},
  publisher    = {{eLife Sciences Publications}},
  series       = {{eLife}},
  title        = {{Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division}},
  url          = {{http://dx.doi.org/10.7554/eLife.25014}},
  doi          = {{10.7554/eLife.25014}},
  volume       = {{6}},
  year         = {{2017}},
}