Prophylactic 3-hour graduated infusion schedule minimizes risk of carboplatin hypersensitivity reactions - A prospective study
(2018) In Gynecologic Oncology 148(2). p.363-367- Abstract
Objective: Aim of this study was observation of hypersensitivity reaction (HSR) frequency by using a 3-hour graduated infusion protocol with appropriate premedication as a prophylactic measure in patients with gynecological cancer receiving carboplatin retreatment in second line or above. None of the patients had experienced HSRs to platinum previously. Method: All the patients in this study received premedication with corticosteroids and anti-histamines followed by carboplatin as 3-hour graduated infusion. Carboplatin was administered either as monotherapy or in combination with other chemotherapeutic agents. Results: Ninety-nine patients with ovarian (n = 71), fallopian tube (n = 9), peritoneal (n = 9) and other gynecological cancers... (More)
Objective: Aim of this study was observation of hypersensitivity reaction (HSR) frequency by using a 3-hour graduated infusion protocol with appropriate premedication as a prophylactic measure in patients with gynecological cancer receiving carboplatin retreatment in second line or above. None of the patients had experienced HSRs to platinum previously. Method: All the patients in this study received premedication with corticosteroids and anti-histamines followed by carboplatin as 3-hour graduated infusion. Carboplatin was administered either as monotherapy or in combination with other chemotherapeutic agents. Results: Ninety-nine patients with ovarian (n = 71), fallopian tube (n = 9), peritoneal (n = 9) and other gynecological cancers (5 uterine cancer, 5 abdominal cancer of gynecological origin) were retreated by a total of 611. cycles of carboplatin administered as monotherapy (210. cycles) or combination regime (401. cycles). HSRs were recorded in only 11. cycles (1.8%) in a total of 11 patients. While 8 of these patients had grade 1or 2 reactions (8.1%), only 3 patients had grade 3 reactions (3%). After pause in the infusion and complete resolution of HSR symptoms, an attempt of retreatment using this infusion protocol with extra premedication was successful in 6 of these patients without any reoccurrence of HSRs. Conclusion: In this prospective study, we report that prophylactic 3-hour graduated infusion rate with appropriate premedication is associated with low frequency of HSRs in gynecological cancer patients requiring carboplatin retreatment in second line or above.
(Less)
- author
- Koul, Anjila LU ; Forsland, Eva L. and Bjurberg, Maria LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Carboplatin, Hypersensitivity reactions, Ovarian cancer
- in
- Gynecologic Oncology
- volume
- 148
- issue
- 2
- pages
- 363 - 367
- publisher
- Academic Press
- external identifiers
-
- scopus:85036563675
- pmid:29208369
- ISSN
- 0090-8258
- DOI
- 10.1016/j.ygyno.2017.11.032
- language
- English
- LU publication?
- yes
- id
- 5a14fd45-0c17-454c-93b7-f8ca98eb0666
- date added to LUP
- 2018-01-10 14:41:02
- date last changed
- 2024-03-01 11:09:44
@article{5a14fd45-0c17-454c-93b7-f8ca98eb0666,
abstract = {{<p>Objective: Aim of this study was observation of hypersensitivity reaction (HSR) frequency by using a 3-hour graduated infusion protocol with appropriate premedication as a prophylactic measure in patients with gynecological cancer receiving carboplatin retreatment in second line or above. None of the patients had experienced HSRs to platinum previously. Method: All the patients in this study received premedication with corticosteroids and anti-histamines followed by carboplatin as 3-hour graduated infusion. Carboplatin was administered either as monotherapy or in combination with other chemotherapeutic agents. Results: Ninety-nine patients with ovarian (n = 71), fallopian tube (n = 9), peritoneal (n = 9) and other gynecological cancers (5 uterine cancer, 5 abdominal cancer of gynecological origin) were retreated by a total of 611. cycles of carboplatin administered as monotherapy (210. cycles) or combination regime (401. cycles). HSRs were recorded in only 11. cycles (1.8%) in a total of 11 patients. While 8 of these patients had grade 1or 2 reactions (8.1%), only 3 patients had grade 3 reactions (3%). After pause in the infusion and complete resolution of HSR symptoms, an attempt of retreatment using this infusion protocol with extra premedication was successful in 6 of these patients without any reoccurrence of HSRs. Conclusion: In this prospective study, we report that prophylactic 3-hour graduated infusion rate with appropriate premedication is associated with low frequency of HSRs in gynecological cancer patients requiring carboplatin retreatment in second line or above.</p>}},
author = {{Koul, Anjila and Forsland, Eva L. and Bjurberg, Maria}},
issn = {{0090-8258}},
keywords = {{Carboplatin; Hypersensitivity reactions; Ovarian cancer}},
language = {{eng}},
number = {{2}},
pages = {{363--367}},
publisher = {{Academic Press}},
series = {{Gynecologic Oncology}},
title = {{Prophylactic 3-hour graduated infusion schedule minimizes risk of carboplatin hypersensitivity reactions - A prospective study}},
url = {{http://dx.doi.org/10.1016/j.ygyno.2017.11.032}},
doi = {{10.1016/j.ygyno.2017.11.032}},
volume = {{148}},
year = {{2018}},
}