Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood
(2012) In Neurobiology of Aging 33.- Abstract
- It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after... (More)
- It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1937038
- author
- Lövdén, Martin LU ; Schaefer, Sabine ; Noack, Hannes ; Bodammer, Nils Christian ; Kühn, Simone ; Heinze, Hans-Jochen ; Düzel, Emrah ; Bäckman, Lars and Lindenberger, Ulman
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurobiology of Aging
- volume
- 33
- publisher
- Elsevier
- external identifiers
-
- wos:000299786000027
- scopus:84855760423
- pmid:21497950
- ISSN
- 1558-1497
- DOI
- 10.1016/j.neurobiolaging.2011.02.013
- language
- English
- LU publication?
- yes
- id
- 5a39fd93-b2d5-4149-bb01-6a0604b2c641 (old id 1937038)
- date added to LUP
- 2016-04-01 10:19:13
- date last changed
- 2022-04-27 20:50:23
@article{5a39fd93-b2d5-4149-bb01-6a0604b2c641, abstract = {{It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.}}, author = {{Lövdén, Martin and Schaefer, Sabine and Noack, Hannes and Bodammer, Nils Christian and Kühn, Simone and Heinze, Hans-Jochen and Düzel, Emrah and Bäckman, Lars and Lindenberger, Ulman}}, issn = {{1558-1497}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Neurobiology of Aging}}, title = {{Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood}}, url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2011.02.013}}, doi = {{10.1016/j.neurobiolaging.2011.02.013}}, volume = {{33}}, year = {{2012}}, }