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Does next-generation sequencing of cyst fluid improve management of pancreatic cystic neoplasms?

Aronsson, Linus LU ; Andersson, Roland LU ; Swahn, Fredrik LU and Ansari, Daniel LU (2017) In Scandinavian Journal of Gastroenterology 52(10). p.1049-1051
Abstract

Pancreatic cystic lesions represent a heterogeneous group of diseases ranging from benign to malignant lesions. They are increasingly being detected due to the widespread use of cross-sectional imaging. Their management is a challenge because it is often not possible to reliably discriminate between malignant and nonmalignant lesions using current imaging technology. Next-generation sequencing (NGS) has the ability of both whole genome and targeted sequencing at a low cost and from a limited amount of DNA. NGS of cyst fluid aspired by endoscopic ultrasonography-guided fine-needle aspiration provides a valuable tool in biomarker research and may in the future help improve diagnosis and management of pancreatic cystic lesions.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarker, cyst fluid, next-generation sequencing, Pancreatic cystic lesions
in
Scandinavian Journal of Gastroenterology
volume
52
issue
10
pages
3 pages
publisher
Taylor & Francis
external identifiers
  • pmid:28678564
  • wos:000417656400003
  • scopus:85028673488
ISSN
0036-5521
DOI
10.1080/00365521.2017.1349175
language
English
LU publication?
yes
id
5a9a59e5-8c54-433d-b53b-90889e3ac5c2
date added to LUP
2017-10-02 15:24:16
date last changed
2025-01-07 21:39:30
@article{5a9a59e5-8c54-433d-b53b-90889e3ac5c2,
  abstract     = {{<p>Pancreatic cystic lesions represent a heterogeneous group of diseases ranging from benign to malignant lesions. They are increasingly being detected due to the widespread use of cross-sectional imaging. Their management is a challenge because it is often not possible to reliably discriminate between malignant and nonmalignant lesions using current imaging technology. Next-generation sequencing (NGS) has the ability of both whole genome and targeted sequencing at a low cost and from a limited amount of DNA. NGS of cyst fluid aspired by endoscopic ultrasonography-guided fine-needle aspiration provides a valuable tool in biomarker research and may in the future help improve diagnosis and management of pancreatic cystic lesions.</p>}},
  author       = {{Aronsson, Linus and Andersson, Roland and Swahn, Fredrik and Ansari, Daniel}},
  issn         = {{0036-5521}},
  keywords     = {{biomarker; cyst fluid; next-generation sequencing; Pancreatic cystic lesions}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{1049--1051}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Does next-generation sequencing of cyst fluid improve management of pancreatic cystic neoplasms?}},
  url          = {{http://dx.doi.org/10.1080/00365521.2017.1349175}},
  doi          = {{10.1080/00365521.2017.1349175}},
  volume       = {{52}},
  year         = {{2017}},
}