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Does next-generation sequencing of cyst fluid improve management of pancreatic cystic neoplasms?

Aronsson, Linus LU ; Andersson, Roland LU ; Swahn, Fredrik LU and Ansari, Daniel LU (2017) In Scandinavian Journal of Gastroenterology 52(10). p.1049-1051
Abstract

Pancreatic cystic lesions represent a heterogeneous group of diseases ranging from benign to malignant lesions. They are increasingly being detected due to the widespread use of cross-sectional imaging. Their management is a challenge because it is often not possible to reliably discriminate between malignant and nonmalignant lesions using current imaging technology. Next-generation sequencing (NGS) has the ability of both whole genome and targeted sequencing at a low cost and from a limited amount of DNA. NGS of cyst fluid aspired by endoscopic ultrasonography-guided fine-needle aspiration provides a valuable tool in biomarker research and may in the future help improve diagnosis and management of pancreatic cystic lesions.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarker, cyst fluid, next-generation sequencing, Pancreatic cystic lesions
in
Scandinavian Journal of Gastroenterology
volume
52
issue
10
pages
3 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85028673488
  • wos:000417656400003
ISSN
0036-5521
DOI
10.1080/00365521.2017.1349175
language
English
LU publication?
yes
id
5a9a59e5-8c54-433d-b53b-90889e3ac5c2
date added to LUP
2017-10-02 15:24:16
date last changed
2018-01-16 13:20:17
@article{5a9a59e5-8c54-433d-b53b-90889e3ac5c2,
  abstract     = {<p>Pancreatic cystic lesions represent a heterogeneous group of diseases ranging from benign to malignant lesions. They are increasingly being detected due to the widespread use of cross-sectional imaging. Their management is a challenge because it is often not possible to reliably discriminate between malignant and nonmalignant lesions using current imaging technology. Next-generation sequencing (NGS) has the ability of both whole genome and targeted sequencing at a low cost and from a limited amount of DNA. NGS of cyst fluid aspired by endoscopic ultrasonography-guided fine-needle aspiration provides a valuable tool in biomarker research and may in the future help improve diagnosis and management of pancreatic cystic lesions.</p>},
  author       = {Aronsson, Linus and Andersson, Roland and Swahn, Fredrik and Ansari, Daniel},
  issn         = {0036-5521},
  keyword      = {biomarker,cyst fluid,next-generation sequencing,Pancreatic cystic lesions},
  language     = {eng},
  month        = {10},
  number       = {10},
  pages        = {1049--1051},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Does next-generation sequencing of cyst fluid improve management of pancreatic cystic neoplasms?},
  url          = {http://dx.doi.org/10.1080/00365521.2017.1349175},
  volume       = {52},
  year         = {2017},
}