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Cancer dissemination--lessons from leukocytes

Madsen, Chris D LU and Sahai, Erik (2010) In Developmental Cell 19(1). p.13-26
Abstract

Cancer cells can move through tissues in a variety of different ways. In some cases, an epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory properties. However, it is also becoming apparent that some cancer cells move in an amoeboid way similar to leukocytes. This theme will be the focus of the review, where we will discuss the similarities and differences between the mechanisms used by cancer cells and leukocytes to cross parenchymal basement membranes, move through interstitial tissue, and enter and exit the vasculature. Further, we propose that the ability to switch between different migratory mechanisms is critical for cells to relocate from one tissue to another.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Actins, Animals, Basement Membrane, Cell Adhesion, Cell Movement, Connective Tissue, Endothelial Cells, Humans, Integrins, Leukocytes, Lymphatic Metastasis, Models, Biological, Neoplasm Invasiveness, Neoplasms, Neoplastic Cells, Circulating, Peptide Hydrolases, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Developmental Cell
volume
19
issue
1
pages
13 - 26
publisher
Cell Press
external identifiers
  • scopus:77954897360
ISSN
1534-5807
DOI
10.1016/j.devcel.2010.06.013
language
English
LU publication?
no
id
5abac59a-b491-4f7f-a4e1-547c9ebc99e5
date added to LUP
2016-12-06 10:16:57
date last changed
2018-06-17 05:18:08
@article{5abac59a-b491-4f7f-a4e1-547c9ebc99e5,
  abstract     = {<p>Cancer cells can move through tissues in a variety of different ways. In some cases, an epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory properties. However, it is also becoming apparent that some cancer cells move in an amoeboid way similar to leukocytes. This theme will be the focus of the review, where we will discuss the similarities and differences between the mechanisms used by cancer cells and leukocytes to cross parenchymal basement membranes, move through interstitial tissue, and enter and exit the vasculature. Further, we propose that the ability to switch between different migratory mechanisms is critical for cells to relocate from one tissue to another.</p>},
  author       = {Madsen, Chris D and Sahai, Erik},
  issn         = {1534-5807},
  keyword      = {Actins,Animals,Basement Membrane,Cell Adhesion,Cell Movement,Connective Tissue,Endothelial Cells,Humans,Integrins,Leukocytes,Lymphatic Metastasis,Models, Biological,Neoplasm Invasiveness,Neoplasms,Neoplastic Cells, Circulating,Peptide Hydrolases,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  month        = {07},
  number       = {1},
  pages        = {13--26},
  publisher    = {Cell Press},
  series       = {Developmental Cell},
  title        = {Cancer dissemination--lessons from leukocytes},
  url          = {http://dx.doi.org/10.1016/j.devcel.2010.06.013},
  volume       = {19},
  year         = {2010},
}