Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery-the influence of external oxytocin
(2009) In Gynecological Endocrinology 25(3). p.188-193- Abstract
- The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F2 and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.520.37 oxytocin receptor/actin; medianSEM) than those delivered with ongoing labour at term (1.010.34; p=0.015) and those at preterm (1.080.25; p=0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to... (More)
- The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F2 and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.520.37 oxytocin receptor/actin; medianSEM) than those delivered with ongoing labour at term (1.010.34; p=0.015) and those at preterm (1.080.25; p=0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to patients receiving oxytocin during labour (p=0.007). These patients had higher oxytocin peptide mRNA levels than those without labour at term (p=0.009). PGF2 receptor mRNA concentrations were 27.803.55, 11.462.87 and 19.545.52 PGF receptor/actin, respectively, for the groups. Women without labour at term had higher concentration than those with labour (p=0.005). Our results suggest that oxytocin, its receptor and the PGF2 receptor are involved in the regulation of labour through a paracrine mechanism. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1427947
- author
- Liedman, Ragner LU ; Hansson, Stefan LU ; Igidbashian, Sarah and Åkerlund, Mats LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- oxytocin receptor, oxytocin, mRNA expression, PGF2 receptor, preterm and term delivery, estrogen receptor and, progesterone receptor
- in
- Gynecological Endocrinology
- volume
- 25
- issue
- 3
- pages
- 188 - 193
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000265294400008
- pmid:19347709
- scopus:67651235458
- ISSN
- 0951-3590
- DOI
- 10.1080/09513590802573213
- language
- English
- LU publication?
- yes
- id
- 5b2b73db-2639-437b-898a-19558959ac1e (old id 1427947)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19347709?dopt=Abstract
- date added to LUP
- 2016-04-01 12:37:39
- date last changed
- 2022-01-27 07:39:28
@article{5b2b73db-2639-437b-898a-19558959ac1e, abstract = {{The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F2 and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.520.37 oxytocin receptor/actin; medianSEM) than those delivered with ongoing labour at term (1.010.34; p=0.015) and those at preterm (1.080.25; p=0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to patients receiving oxytocin during labour (p=0.007). These patients had higher oxytocin peptide mRNA levels than those without labour at term (p=0.009). PGF2 receptor mRNA concentrations were 27.803.55, 11.462.87 and 19.545.52 PGF receptor/actin, respectively, for the groups. Women without labour at term had higher concentration than those with labour (p=0.005). Our results suggest that oxytocin, its receptor and the PGF2 receptor are involved in the regulation of labour through a paracrine mechanism.}}, author = {{Liedman, Ragner and Hansson, Stefan and Igidbashian, Sarah and Åkerlund, Mats}}, issn = {{0951-3590}}, keywords = {{oxytocin receptor; oxytocin; mRNA expression; PGF2 receptor; preterm and term delivery; estrogen receptor and; progesterone receptor}}, language = {{eng}}, number = {{3}}, pages = {{188--193}}, publisher = {{Informa Healthcare}}, series = {{Gynecological Endocrinology}}, title = {{Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery-the influence of external oxytocin}}, url = {{http://dx.doi.org/10.1080/09513590802573213}}, doi = {{10.1080/09513590802573213}}, volume = {{25}}, year = {{2009}}, }