Sphingomyelinase and ceramidase in the intestinal tract
(2007) In European Journal of Lipid Science and Technology 109(10). p.987-993- Abstract
- Sphingomyelin (SM) has emerged as an important source of lipid messengers affecting cell proliferation, differentiation and apoptosis. SM is present in mammalian cell membranes as a lipid constituent and also found as a component of dietary products such as milk, egg and meat. Digestion of SM has been found to have important implications in colon cancer development, gut maturation, and cholesterol absorption. SM in the intestine is sequentially digested by alkaline sphingomyelinase and neutral ceramidase before absorption. In the last decade, rapid progress has been made in many aspects of these two enzymes. The review intends to provide a short summary of the current knowledge on the properties, functions and the pathological changes of... (More)
- Sphingomyelin (SM) has emerged as an important source of lipid messengers affecting cell proliferation, differentiation and apoptosis. SM is present in mammalian cell membranes as a lipid constituent and also found as a component of dietary products such as milk, egg and meat. Digestion of SM has been found to have important implications in colon cancer development, gut maturation, and cholesterol absorption. SM in the intestine is sequentially digested by alkaline sphingomyelinase and neutral ceramidase before absorption. In the last decade, rapid progress has been made in many aspects of these two enzymes. The review intends to provide a short summary of the current knowledge on the properties, functions and the pathological changes of the enzymes in the intestinal tract. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/653171
- author
- Duan, Rui-Dong LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cholesterol absorption, cancer, intestine, sphingomyelinase, ceramidase
- in
- European Journal of Lipid Science and Technology
- volume
- 109
- issue
- 10
- pages
- 987 - 993
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000250496800005
- scopus:35548930265
- ISSN
- 1438-7697
- DOI
- 10.1002/ejlt.200700074
- language
- English
- LU publication?
- yes
- id
- 5b4ae15b-b1a8-4e4a-9295-f4c00a5a1153 (old id 653171)
- date added to LUP
- 2016-04-01 12:18:06
- date last changed
- 2024-01-08 15:44:31
@article{5b4ae15b-b1a8-4e4a-9295-f4c00a5a1153,
abstract = {{Sphingomyelin (SM) has emerged as an important source of lipid messengers affecting cell proliferation, differentiation and apoptosis. SM is present in mammalian cell membranes as a lipid constituent and also found as a component of dietary products such as milk, egg and meat. Digestion of SM has been found to have important implications in colon cancer development, gut maturation, and cholesterol absorption. SM in the intestine is sequentially digested by alkaline sphingomyelinase and neutral ceramidase before absorption. In the last decade, rapid progress has been made in many aspects of these two enzymes. The review intends to provide a short summary of the current knowledge on the properties, functions and the pathological changes of the enzymes in the intestinal tract.}},
author = {{Duan, Rui-Dong}},
issn = {{1438-7697}},
keywords = {{cholesterol absorption; cancer; intestine; sphingomyelinase; ceramidase}},
language = {{eng}},
number = {{10}},
pages = {{987--993}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Lipid Science and Technology}},
title = {{Sphingomyelinase and ceramidase in the intestinal tract}},
url = {{http://dx.doi.org/10.1002/ejlt.200700074}},
doi = {{10.1002/ejlt.200700074}},
volume = {{109}},
year = {{2007}},
}