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A new understanding of pancreatitis-associated pulmonary injury

Zhao, Xia LU ; Shi, Changbin LU ; Wang, Xiangdong LU and Andersson, Roland LU (2006) In Journal of Organ Dysfuntion 2(3). p.156-165
Abstract
Pancreatitis-associated lung injury (PALI) is one of the earliest organ dysfunctions occurring in patients with severe acute pancreatitis. In this review we explore potential mechanisms of endothelial barrier dysfunction, neutrophil and monocyte/macrophage activation, adhesion molecule expression, initial factors, mast cell involvement and intracellular signaling in PALI. Different regulatory mechanisms exist in PALI and sepsis-induced lung injury. Endothelial barrier dysfunction occurs early on in acute pancreatitis and tumor necrosis factor (TNF)-agr and monocyte chemoattractive protein-1 levels in the circulation gradually increase in acute pancreatitis. Leukocytes from the circulation, lung tissue and bronchoalveolar fluid exhibit... (More)
Pancreatitis-associated lung injury (PALI) is one of the earliest organ dysfunctions occurring in patients with severe acute pancreatitis. In this review we explore potential mechanisms of endothelial barrier dysfunction, neutrophil and monocyte/macrophage activation, adhesion molecule expression, initial factors, mast cell involvement and intracellular signaling in PALI. Different regulatory mechanisms exist in PALI and sepsis-induced lung injury. Endothelial barrier dysfunction occurs early on in acute pancreatitis and tumor necrosis factor (TNF)-agr and monocyte chemoattractive protein-1 levels in the circulation gradually increase in acute pancreatitis. Leukocytes from the circulation, lung tissue and bronchoalveolar fluid exhibit different expression and activation patterns in the development of PALI. Mast cells seem to be involved in the initiation of leukocyte activation during the initial phase of PALI. Activation of the protein kinase C (PKC) signaling pathway could play an important role in the pathogenesis of PALI. Inhibition of PKC may be one candidate to prevent and treat the development of PALI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adhesion molecules, mast cells, acute respiratory distress syndrome, Acute pancreatitis, lung injury, protein kinase C
in
Journal of Organ Dysfuntion
volume
2
issue
3
pages
156 - 165
publisher
Informa Healthcare
external identifiers
  • scopus:33748455055
ISSN
1747-1060
DOI
10.1080/17471060600799520
language
English
LU publication?
yes
id
5b68563e-eef6-44a0-b0e3-f4ce67630f15 (old id 1137135)
date added to LUP
2008-06-10 11:54:57
date last changed
2019-02-20 04:29:49
@article{5b68563e-eef6-44a0-b0e3-f4ce67630f15,
  abstract     = {Pancreatitis-associated lung injury (PALI) is one of the earliest organ dysfunctions occurring in patients with severe acute pancreatitis. In this review we explore potential mechanisms of endothelial barrier dysfunction, neutrophil and monocyte/macrophage activation, adhesion molecule expression, initial factors, mast cell involvement and intracellular signaling in PALI. Different regulatory mechanisms exist in PALI and sepsis-induced lung injury. Endothelial barrier dysfunction occurs early on in acute pancreatitis and tumor necrosis factor (TNF)-agr and monocyte chemoattractive protein-1 levels in the circulation gradually increase in acute pancreatitis. Leukocytes from the circulation, lung tissue and bronchoalveolar fluid exhibit different expression and activation patterns in the development of PALI. Mast cells seem to be involved in the initiation of leukocyte activation during the initial phase of PALI. Activation of the protein kinase C (PKC) signaling pathway could play an important role in the pathogenesis of PALI. Inhibition of PKC may be one candidate to prevent and treat the development of PALI.},
  author       = {Zhao, Xia and Shi, Changbin and Wang, Xiangdong and Andersson, Roland},
  issn         = {1747-1060},
  keyword      = {adhesion molecules,mast cells,acute respiratory distress syndrome,Acute pancreatitis,lung injury,protein kinase C},
  language     = {eng},
  number       = {3},
  pages        = {156--165},
  publisher    = {Informa Healthcare},
  series       = {Journal of Organ Dysfuntion},
  title        = {A new understanding of pancreatitis-associated pulmonary injury},
  url          = {http://dx.doi.org/10.1080/17471060600799520},
  volume       = {2},
  year         = {2006},
}