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Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus

Bjarnegard, N; Bengtsson, Christine LU ; Brodszki, Jana LU ; Sturfelt, Gunnar LU ; Nived, Ola LU and Lanne, T (2006) In Lupus 15(10). p.644-650
Abstract
Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls. Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P < 0.01), after correction for mean... (More)
Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls. Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P < 0.01), after correction for mean arterial pressure and body mass index, 9.5 m/s versus 8.5 m/s (P < 0.05). Other parameters were similar, arm PWV, 8.4 versus 8.5 m/s, AIx 34 versus 33% and calculated central aortic pulse pressure 48 versus 43 mmHg, in SLE and controls, respectively (NS). Aortic PWV was positively associated to C-reactive protein (CRP) and complement factor 3 (C3). Women with SLE have increased stiffness of their elastic central arteries. This may be one factor contributing to the increased cardiovascular risk seen in this cohort. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arteries, blood pressure, elasticity, pulse, SLE, women
in
Lupus
volume
15
issue
10
pages
644 - 650
publisher
SAGE Publications Ltd
external identifiers
  • wos:000241952100002
  • scopus:33750594398
ISSN
0961-2033
DOI
10.1177/0961203306071402
language
English
LU publication?
yes
id
5b8f2124-4303-4ade-acc3-0361953f6820 (old id 1134453)
date added to LUP
2008-05-16 15:56:56
date last changed
2019-01-20 04:00:36
@article{5b8f2124-4303-4ade-acc3-0361953f6820,
  abstract     = {Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls. Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P &lt; 0.01), after correction for mean arterial pressure and body mass index, 9.5 m/s versus 8.5 m/s (P &lt; 0.05). Other parameters were similar, arm PWV, 8.4 versus 8.5 m/s, AIx 34 versus 33% and calculated central aortic pulse pressure 48 versus 43 mmHg, in SLE and controls, respectively (NS). Aortic PWV was positively associated to C-reactive protein (CRP) and complement factor 3 (C3). Women with SLE have increased stiffness of their elastic central arteries. This may be one factor contributing to the increased cardiovascular risk seen in this cohort.},
  author       = {Bjarnegard, N and Bengtsson, Christine and Brodszki, Jana and Sturfelt, Gunnar and Nived, Ola and Lanne, T},
  issn         = {0961-2033},
  keyword      = {arteries,blood pressure,elasticity,pulse,SLE,women},
  language     = {eng},
  number       = {10},
  pages        = {644--650},
  publisher    = {SAGE Publications Ltd},
  series       = {Lupus},
  title        = {Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1177/0961203306071402},
  volume       = {15},
  year         = {2006},
}