Obesity and metabolic disturbances in adamantinomatous craniopharyngioma patients
(2017) p.85-99- Abstract
An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of patients have an extended hypopituitarism that needs balanced hormone supplementation. About half of the patient population suffer from hypothalamic damage due to the tumour or operation. These patients suffer from hypothalamic obesity together with increased vascular morbidity and compromised bone health, thirst disorders as well as somnolence... (More)
An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of patients have an extended hypopituitarism that needs balanced hormone supplementation. About half of the patient population suffer from hypothalamic damage due to the tumour or operation. These patients suffer from hypothalamic obesity together with increased vascular morbidity and compromised bone health, thirst disorders as well as somnolence and sleep apnea. Cardiovascular risk factors need up front therapy. There is a need for centralising this rare aggressive and difficult tumour to only a few centres and that it will be managed by a multidisciplinary team with experienced neurosurgeons, endocrinologists, neurooncologists, neuroradiologists, and neuroopthamologists for a better prognosis.
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- author
- Erfurth, Eva Marie LU
- organization
- publishing date
- 2017-04-19
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Bone mineral density, Cardiovascular diseases, Cardiovascular morbidity, Cardiovascular mortality, Cardiovascular risk factors, Childhood craniopharyngioma, Hypothalamic damage, Insulin, Leptin resistance
- host publication
- Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma
- pages
- 15 pages
- publisher
- Springer International Publishing
- external identifiers
-
- scopus:85033352955
- ISBN
- 9783319518886
- 9783319518909
- DOI
- 10.1007/978-3-319-51890-9_6
- language
- English
- LU publication?
- yes
- id
- 5be196cc-d81e-469e-a0b7-8d93242da710
- date added to LUP
- 2017-12-12 15:40:12
- date last changed
- 2024-05-13 03:26:35
@inbook{5be196cc-d81e-469e-a0b7-8d93242da710,
abstract = {{<p>An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of patients have an extended hypopituitarism that needs balanced hormone supplementation. About half of the patient population suffer from hypothalamic damage due to the tumour or operation. These patients suffer from hypothalamic obesity together with increased vascular morbidity and compromised bone health, thirst disorders as well as somnolence and sleep apnea. Cardiovascular risk factors need up front therapy. There is a need for centralising this rare aggressive and difficult tumour to only a few centres and that it will be managed by a multidisciplinary team with experienced neurosurgeons, endocrinologists, neurooncologists, neuroradiologists, and neuroopthamologists for a better prognosis.</p>}},
author = {{Erfurth, Eva Marie}},
booktitle = {{Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma}},
isbn = {{9783319518886}},
keywords = {{Bone mineral density; Cardiovascular diseases; Cardiovascular morbidity; Cardiovascular mortality; Cardiovascular risk factors; Childhood craniopharyngioma; Hypothalamic damage; Insulin; Leptin resistance}},
language = {{eng}},
month = {{04}},
pages = {{85--99}},
publisher = {{Springer International Publishing}},
title = {{Obesity and metabolic disturbances in adamantinomatous craniopharyngioma patients}},
url = {{http://dx.doi.org/10.1007/978-3-319-51890-9_6}},
doi = {{10.1007/978-3-319-51890-9_6}},
year = {{2017}},
}