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Obesity and metabolic disturbances in adamantinomatous craniopharyngioma patients

Erfurth, Eva Marie LU (2017) In Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma p.85-99
Abstract

An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of patients have an extended hypopituitarism that needs balanced hormone supplementation. About half of the patient population suffer from hypothalamic damage due to the tumour or operation. These patients suffer from hypothalamic obesity together with increased vascular morbidity and compromised bone health, thirst disorders as well as somnolence... (More)

An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of patients have an extended hypopituitarism that needs balanced hormone supplementation. About half of the patient population suffer from hypothalamic damage due to the tumour or operation. These patients suffer from hypothalamic obesity together with increased vascular morbidity and compromised bone health, thirst disorders as well as somnolence and sleep apnea. Cardiovascular risk factors need up front therapy. There is a need for centralising this rare aggressive and difficult tumour to only a few centres and that it will be managed by a multidisciplinary team with experienced neurosurgeons, endocrinologists, neurooncologists, neuroradiologists, and neuroopthamologists for a better prognosis.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Bone mineral density, Cardiovascular diseases, Cardiovascular morbidity, Cardiovascular mortality, Cardiovascular risk factors, Childhood craniopharyngioma, Hypothalamic damage, Insulin, Leptin resistance
in
Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma
pages
15 pages
publisher
Springer International Publishing
external identifiers
  • scopus:85033352955
ISBN
9783319518886
9783319518909
DOI
10.1007/978-3-319-51890-9_6
language
English
LU publication?
yes
id
5be196cc-d81e-469e-a0b7-8d93242da710
date added to LUP
2017-12-12 15:40:12
date last changed
2018-01-07 12:28:34
@inbook{5be196cc-d81e-469e-a0b7-8d93242da710,
  abstract     = {<p>An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of patients have an extended hypopituitarism that needs balanced hormone supplementation. About half of the patient population suffer from hypothalamic damage due to the tumour or operation. These patients suffer from hypothalamic obesity together with increased vascular morbidity and compromised bone health, thirst disorders as well as somnolence and sleep apnea. Cardiovascular risk factors need up front therapy. There is a need for centralising this rare aggressive and difficult tumour to only a few centres and that it will be managed by a multidisciplinary team with experienced neurosurgeons, endocrinologists, neurooncologists, neuroradiologists, and neuroopthamologists for a better prognosis.</p>},
  author       = {Erfurth, Eva Marie},
  isbn         = {9783319518886},
  keyword      = {Bone mineral density,Cardiovascular diseases,Cardiovascular morbidity,Cardiovascular mortality,Cardiovascular risk factors,Childhood craniopharyngioma,Hypothalamic damage,Insulin,Leptin resistance},
  language     = {eng},
  month        = {04},
  pages        = {85--99},
  publisher    = {Springer International Publishing},
  series       = {Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma},
  title        = {Obesity and metabolic disturbances in adamantinomatous craniopharyngioma patients},
  url          = {http://dx.doi.org/10.1007/978-3-319-51890-9_6},
  year         = {2017},
}