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Mild cognitive impairment and Parkinson's disease - something to remember

Barker, Roger A LU and Williams-Gray, Caroline H (2014) In Journal of Parkinson's Disease 4(4). p.6-651
Abstract

Cognitive impairment is common in Parkinson's disease (PD), and many patients will eventually develop a dementia, which has a devastating impact on the patient and their family. As such, there has been much interest in identifying a prodromal state to inform prognosis and facilitate earlier management, similar to the concept of 'MCI' in the Alzheimer's field. However, grouping the early cognitive deficits of PD together as 'PD-MCI' may not be the best way forward as it implies a single aetiological basis with one clinical consequence. In this review, we argue that cognitive deficits in PD arise from a number of different pathological pathways, only some of which herald a dementing process. This has important implications both for... (More)

Cognitive impairment is common in Parkinson's disease (PD), and many patients will eventually develop a dementia, which has a devastating impact on the patient and their family. As such, there has been much interest in identifying a prodromal state to inform prognosis and facilitate earlier management, similar to the concept of 'MCI' in the Alzheimer's field. However, grouping the early cognitive deficits of PD together as 'PD-MCI' may not be the best way forward as it implies a single aetiological basis with one clinical consequence. In this review, we argue that cognitive deficits in PD arise from a number of different pathological pathways, only some of which herald a dementing process. This has important implications both for treatment of individual patients, and for the design of future disease-modifying therapy trials.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Humans, Mild Cognitive Impairment, Neuropsychological Tests, Parkinson Disease, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Journal of Parkinson's Disease
volume
4
issue
4
pages
6 pages
publisher
IOS Press
external identifiers
  • scopus:84914692698
ISSN
1877-718X
DOI
10.3233/JPD-140427
language
English
LU publication?
no
id
5c53af83-f659-4ea8-800f-49ad12090cfb
date added to LUP
2016-11-24 15:02:47
date last changed
2017-09-10 05:12:08
@article{5c53af83-f659-4ea8-800f-49ad12090cfb,
  abstract     = {<p>Cognitive impairment is common in Parkinson's disease (PD), and many patients will eventually develop a dementia, which has a devastating impact on the patient and their family. As such, there has been much interest in identifying a prodromal state to inform prognosis and facilitate earlier management, similar to the concept of 'MCI' in the Alzheimer's field. However, grouping the early cognitive deficits of PD together as 'PD-MCI' may not be the best way forward as it implies a single aetiological basis with one clinical consequence. In this review, we argue that cognitive deficits in PD arise from a number of different pathological pathways, only some of which herald a dementing process. This has important implications both for treatment of individual patients, and for the design of future disease-modifying therapy trials.</p>},
  author       = {Barker, Roger A and Williams-Gray, Caroline H},
  issn         = {1877-718X},
  keyword      = {Humans,Mild Cognitive Impairment,Neuropsychological Tests,Parkinson Disease,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {4},
  pages        = {6--651},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Mild cognitive impairment and Parkinson's disease - something to remember},
  url          = {http://dx.doi.org/10.3233/JPD-140427},
  volume       = {4},
  year         = {2014},
}