Mild cognitive impairment and Parkinson's disease - something to remember
(2014) In Journal of Parkinson's Disease 4(4). p.6-651- Abstract
Cognitive impairment is common in Parkinson's disease (PD), and many patients will eventually develop a dementia, which has a devastating impact on the patient and their family. As such, there has been much interest in identifying a prodromal state to inform prognosis and facilitate earlier management, similar to the concept of 'MCI' in the Alzheimer's field. However, grouping the early cognitive deficits of PD together as 'PD-MCI' may not be the best way forward as it implies a single aetiological basis with one clinical consequence. In this review, we argue that cognitive deficits in PD arise from a number of different pathological pathways, only some of which herald a dementing process. This has important implications both for... (More)
Cognitive impairment is common in Parkinson's disease (PD), and many patients will eventually develop a dementia, which has a devastating impact on the patient and their family. As such, there has been much interest in identifying a prodromal state to inform prognosis and facilitate earlier management, similar to the concept of 'MCI' in the Alzheimer's field. However, grouping the early cognitive deficits of PD together as 'PD-MCI' may not be the best way forward as it implies a single aetiological basis with one clinical consequence. In this review, we argue that cognitive deficits in PD arise from a number of different pathological pathways, only some of which herald a dementing process. This has important implications both for treatment of individual patients, and for the design of future disease-modifying therapy trials.
(Less)
- author
- Barker, Roger A LU and Williams-Gray, Caroline H
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- keywords
- Humans, Mild Cognitive Impairment, Neuropsychological Tests, Parkinson Disease, Journal Article, Research Support, Non-U.S. Gov't, Review
- in
- Journal of Parkinson's Disease
- volume
- 4
- issue
- 4
- pages
- 6 pages
- publisher
- IOS Press
- external identifiers
-
- scopus:84914692698
- pmid:25147139
- ISSN
- 1877-718X
- DOI
- 10.3233/JPD-140427
- language
- English
- LU publication?
- no
- id
- 5c53af83-f659-4ea8-800f-49ad12090cfb
- date added to LUP
- 2016-11-24 15:02:47
- date last changed
- 2024-05-03 14:30:48
@article{5c53af83-f659-4ea8-800f-49ad12090cfb,
abstract = {{<p>Cognitive impairment is common in Parkinson's disease (PD), and many patients will eventually develop a dementia, which has a devastating impact on the patient and their family. As such, there has been much interest in identifying a prodromal state to inform prognosis and facilitate earlier management, similar to the concept of 'MCI' in the Alzheimer's field. However, grouping the early cognitive deficits of PD together as 'PD-MCI' may not be the best way forward as it implies a single aetiological basis with one clinical consequence. In this review, we argue that cognitive deficits in PD arise from a number of different pathological pathways, only some of which herald a dementing process. This has important implications both for treatment of individual patients, and for the design of future disease-modifying therapy trials.</p>}},
author = {{Barker, Roger A and Williams-Gray, Caroline H}},
issn = {{1877-718X}},
keywords = {{Humans; Mild Cognitive Impairment; Neuropsychological Tests; Parkinson Disease; Journal Article; Research Support, Non-U.S. Gov't; Review}},
language = {{eng}},
number = {{4}},
pages = {{6--651}},
publisher = {{IOS Press}},
series = {{Journal of Parkinson's Disease}},
title = {{Mild cognitive impairment and Parkinson's disease - something to remember}},
url = {{http://dx.doi.org/10.3233/JPD-140427}},
doi = {{10.3233/JPD-140427}},
volume = {{4}},
year = {{2014}},
}