Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden.
(2012) In Neurodegenerative Diseases 10(1-4). p.277-284- Abstract
- Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple... (More)
- Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks depended on the age at hospitalization for PD. Conclusions: A 33% overall excess risk of PD was noted among patients with an autoimmune disorder; the risk was increased during the first 10 years of follow-up after hospitalization of autoimmune disorders. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2273487
- author
- Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurodegenerative Diseases
- volume
- 10
- issue
- 1-4
- pages
- 277 - 284
- publisher
- Karger
- external identifiers
-
- wos:000303660600060
- pmid:22205172
- scopus:84860223114
- pmid:22205172
- ISSN
- 1660-2862
- DOI
- 10.1159/000333222
- language
- English
- LU publication?
- yes
- id
- 5c85b5e6-7ed7-4c11-820b-f55f498b1fcb (old id 2273487)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22205172?dopt=Abstract
- date added to LUP
- 2016-04-01 09:52:46
- date last changed
- 2022-04-27 08:18:45
@article{5c85b5e6-7ed7-4c11-820b-f55f498b1fcb, abstract = {{Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks depended on the age at hospitalization for PD. Conclusions: A 33% overall excess risk of PD was noted among patients with an autoimmune disorder; the risk was increased during the first 10 years of follow-up after hospitalization of autoimmune disorders.}}, author = {{Li, Xinjun and Sundquist, Jan and Sundquist, Kristina}}, issn = {{1660-2862}}, language = {{eng}}, number = {{1-4}}, pages = {{277--284}}, publisher = {{Karger}}, series = {{Neurodegenerative Diseases}}, title = {{Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden.}}, url = {{https://lup.lub.lu.se/search/files/1347888/2369909.pdf}}, doi = {{10.1159/000333222}}, volume = {{10}}, year = {{2012}}, }