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Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden.

Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2012) In Neurodegenerative Diseases 10(1-4). p.277-284
Abstract
Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple... (More)
Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks depended on the age at hospitalization for PD. Conclusions: A 33% overall excess risk of PD was noted among patients with an autoimmune disorder; the risk was increased during the first 10 years of follow-up after hospitalization of autoimmune disorders. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurodegenerative Diseases
volume
10
issue
1-4
pages
277 - 284
publisher
Karger
external identifiers
  • wos:000303660600060
  • pmid:22205172
  • scopus:84860223114
  • pmid:22205172
ISSN
1660-2862
DOI
10.1159/000333222
language
English
LU publication?
yes
id
5c85b5e6-7ed7-4c11-820b-f55f498b1fcb (old id 2273487)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22205172?dopt=Abstract
date added to LUP
2016-04-01 09:52:46
date last changed
2025-10-14 09:26:49
@article{5c85b5e6-7ed7-4c11-820b-f55f498b1fcb,
  abstract     = {{Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions of autoimmune disorders, 932 patients developed subsequent PD, giving an overall SIR of 1.33 and 1.19 for PD diagnosed later than 1 year after follow-up. Six types of autoimmune disorders showed an increased risk. These conditions included: amyotrophic lateral sclerosis, Graves's disease/hyperthyroidism, Hashimoto's disease/hypothyroidism, multiple sclerosis, pernicious anemia, and polymyalgia rheumatica. The risks depended on the age at hospitalization for PD. Conclusions: A 33% overall excess risk of PD was noted among patients with an autoimmune disorder; the risk was increased during the first 10 years of follow-up after hospitalization of autoimmune disorders.}},
  author       = {{Li, Xinjun and Sundquist, Jan and Sundquist, Kristina}},
  issn         = {{1660-2862}},
  language     = {{eng}},
  number       = {{1-4}},
  pages        = {{277--284}},
  publisher    = {{Karger}},
  series       = {{Neurodegenerative Diseases}},
  title        = {{Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden.}},
  url          = {{https://lup.lub.lu.se/search/files/1347888/2369909.pdf}},
  doi          = {{10.1159/000333222}},
  volume       = {{10}},
  year         = {{2012}},
}