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Increasing number of long-lived ancestors associates with up to a decade of healthspan extension and a healthy metabolomic profile in mid-life

van den Berg, Niels ; Rodríguez-Girondo, Mar ; van Dijk, Ingrid Kirsten LU ; Slagboom, P Eline and Beekman, Marian (2022)
Abstract
Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-generational data from two databases, LLS (Netherlands), and SEDD (Sweden). We study healthspan in 2,143 families containing index persons and two ancestral generations, comprising 17,539 persons with 25 follow-up years. Our results provide strong evidence that an increasing number of long-lived ancestors associates with up to a decade of healthspan... (More)
Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-generational data from two databases, LLS (Netherlands), and SEDD (Sweden). We study healthspan in 2,143 families containing index persons and two ancestral generations, comprising 17,539 persons with 25 follow-up years. Our results provide strong evidence that an increasing number of long-lived ancestors associates with up to a decade of healthspan extension. Further evidence indicates that members of long-lived families have a delayed onset of medication use, multimorbidity and, in mid-life, healthier metabolomic profiles than their partners. We conclude that in longevity families, both lifespan and healthspan are quantitatively linked to ancestral longevity, making such families highly suitable to identify protective mechanisms of multimorbidity. (Less)
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author
; ; ; and
organization
publishing date
type
Working paper/Preprint
publication status
published
subject
publisher
bioRxiv
DOI
10.1101/2022.09.08.507098
project
An Age-Old Advantage? Healthy aging in two centuries of Swedish and Dutch long-lived families (1813-2021). Riksbankens Jubileumsfond.
language
English
LU publication?
yes
id
5e320d29-7972-4e72-9ff8-2b89ae6e57a3
date added to LUP
2022-09-14 17:12:32
date last changed
2022-09-15 10:16:26
@misc{5e320d29-7972-4e72-9ff8-2b89ae6e57a3,
  abstract     = {{Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-generational data from two databases, LLS (Netherlands), and SEDD (Sweden). We study healthspan in 2,143 families containing index persons and two ancestral generations, comprising 17,539 persons with 25 follow-up years. Our results provide strong evidence that an increasing number of long-lived ancestors associates with up to a decade of healthspan extension. Further evidence indicates that members of long-lived families have a delayed onset of medication use, multimorbidity and, in mid-life, healthier metabolomic profiles than their partners. We conclude that in longevity families, both lifespan and healthspan are quantitatively linked to ancestral longevity, making such families highly suitable to identify protective mechanisms of multimorbidity.}},
  author       = {{van den Berg, Niels and Rodríguez-Girondo, Mar and van Dijk, Ingrid Kirsten and Slagboom, P Eline and Beekman, Marian}},
  language     = {{eng}},
  month        = {{09}},
  note         = {{Preprint}},
  publisher    = {{bioRxiv}},
  title        = {{Increasing number of long-lived ancestors associates with up to a decade of healthspan extension and a healthy metabolomic profile in mid-life}},
  url          = {{http://dx.doi.org/10.1101/2022.09.08.507098}},
  doi          = {{10.1101/2022.09.08.507098}},
  year         = {{2022}},
}