Cortical thickness changes following spatial navigation training in adulthood and aging
(2012) In NeuroImage 59(4). p.3389-3397- Abstract
- A widespread network involving cortical and subcortical brain structures forms the neural substrate of human spatial navigation. Most studies investigating plasticity of this network have focused on the hippocampus. Here, we investigate age differences in cortical thickness changes evoked by four months of spatial navigation training in 91 men aged 20-30 or 60-70 years. Cortical thickness was automatically measured before, immediately after, and four months after termination of training. Younger as well as older navigators evidenced large improvements in navigation performance that were partly maintained after termination of training. Importantly, training-related cortical thickening in left precuneus and paracentral lobule were observed... (More)
- A widespread network involving cortical and subcortical brain structures forms the neural substrate of human spatial navigation. Most studies investigating plasticity of this network have focused on the hippocampus. Here, we investigate age differences in cortical thickness changes evoked by four months of spatial navigation training in 91 men aged 20-30 or 60-70 years. Cortical thickness was automatically measured before, immediately after, and four months after termination of training. Younger as well as older navigators evidenced large improvements in navigation performance that were partly maintained after termination of training. Importantly, training-related cortical thickening in left precuneus and paracentral lobule were observed in young navigators only. Thus, spatial navigation training appears to affect cortical brain structure of young adults, but there is reduced potential for experience-dependent cortical alterations in old age. (C) 2011 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2515753
- author
- Wenger, Elisabeth ; Schaefer, Sabine ; Noack, Hannes ; Kuehn, Simone ; Mårtensson, Johan LU ; Heinze, Hans-Jochen ; Duezel, Emrah ; Backman, Lars ; Lindenberger, Ulman and Lövdén, Martin LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Spatial navigation, Aging, Cortical thickness, Plasticity
- in
- NeuroImage
- volume
- 59
- issue
- 4
- pages
- 3389 - 3397
- publisher
- Elsevier
- external identifiers
-
- wos:000301090100035
- scopus:84855174302
- pmid:22108645
- ISSN
- 1095-9572
- DOI
- 10.1016/j.neuroimage.2011.11.015
- language
- English
- LU publication?
- yes
- id
- 5e59f6c0-2706-42d0-b0b0-0ba8b931f311 (old id 2515753)
- date added to LUP
- 2016-04-01 11:00:04
- date last changed
- 2022-03-12 19:02:54
@article{5e59f6c0-2706-42d0-b0b0-0ba8b931f311, abstract = {{A widespread network involving cortical and subcortical brain structures forms the neural substrate of human spatial navigation. Most studies investigating plasticity of this network have focused on the hippocampus. Here, we investigate age differences in cortical thickness changes evoked by four months of spatial navigation training in 91 men aged 20-30 or 60-70 years. Cortical thickness was automatically measured before, immediately after, and four months after termination of training. Younger as well as older navigators evidenced large improvements in navigation performance that were partly maintained after termination of training. Importantly, training-related cortical thickening in left precuneus and paracentral lobule were observed in young navigators only. Thus, spatial navigation training appears to affect cortical brain structure of young adults, but there is reduced potential for experience-dependent cortical alterations in old age. (C) 2011 Elsevier Inc. All rights reserved.}}, author = {{Wenger, Elisabeth and Schaefer, Sabine and Noack, Hannes and Kuehn, Simone and Mårtensson, Johan and Heinze, Hans-Jochen and Duezel, Emrah and Backman, Lars and Lindenberger, Ulman and Lövdén, Martin}}, issn = {{1095-9572}}, keywords = {{Spatial navigation; Aging; Cortical thickness; Plasticity}}, language = {{eng}}, number = {{4}}, pages = {{3389--3397}}, publisher = {{Elsevier}}, series = {{NeuroImage}}, title = {{Cortical thickness changes following spatial navigation training in adulthood and aging}}, url = {{http://dx.doi.org/10.1016/j.neuroimage.2011.11.015}}, doi = {{10.1016/j.neuroimage.2011.11.015}}, volume = {{59}}, year = {{2012}}, }