RNA and metabolic disorders
(2020) p.175-199- Abstract
Obesity is reaching levels never seen before in the world population, causing a rise in the incidence of metabolic disorders. The increase of visceral storage of adipose tissue is related to chronic inflammation and deregulation of the metabolism, causing insulin resistance, dyslipidemia and endothelial dysfunction. These pathologies, when they appear together, are known as metabolic syndrome and are associated with an increased risk of atherosclerotic cardiovascular disease, and type 2 Diabetes Mellitus. Recent studies have demonstrated a close link between maternal nutrition and chronic metabolic disease, suggesting epigenetic mechanisms that could affect the way we face this problem in the future. In such context, is of great... (More)
Obesity is reaching levels never seen before in the world population, causing a rise in the incidence of metabolic disorders. The increase of visceral storage of adipose tissue is related to chronic inflammation and deregulation of the metabolism, causing insulin resistance, dyslipidemia and endothelial dysfunction. These pathologies, when they appear together, are known as metabolic syndrome and are associated with an increased risk of atherosclerotic cardiovascular disease, and type 2 Diabetes Mellitus. Recent studies have demonstrated a close link between maternal nutrition and chronic metabolic disease, suggesting epigenetic mechanisms that could affect the way we face this problem in the future. In such context, is of great importance to fully understand the mechanisms that control expression of the genes involved. In this work we will focus on the role of RNA as a key regulatory element in the control of gene expression in metabolic disorders.
(Less)
- author
- Verma, Gaurav LU and González-Rico, Susana
- organization
- publishing date
- 2020
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Adipogenesis, Epigenetics, Gene regulation, LncRNA, Metabolic syndrome, MiRNA, PiRNA, RNA, SiRNA, Transcriptional control
- host publication
- RNA-Based Regulation in Human Health and Disease
- pages
- 25 pages
- publisher
- ScienceDirect, Elsevier
- external identifiers
-
- scopus:85147600301
- ISBN
- 9780128171936
- DOI
- 10.1016/B978-0-12-817193-6.00008-X
- language
- English
- LU publication?
- yes
- id
- 5e5b25b1-ad02-43a1-8f0e-e176658ce31d
- date added to LUP
- 2023-02-20 15:32:08
- date last changed
- 2023-02-20 15:32:48
@inbook{5e5b25b1-ad02-43a1-8f0e-e176658ce31d,
abstract = {{<p>Obesity is reaching levels never seen before in the world population, causing a rise in the incidence of metabolic disorders. The increase of visceral storage of adipose tissue is related to chronic inflammation and deregulation of the metabolism, causing insulin resistance, dyslipidemia and endothelial dysfunction. These pathologies, when they appear together, are known as metabolic syndrome and are associated with an increased risk of atherosclerotic cardiovascular disease, and type 2 Diabetes Mellitus. Recent studies have demonstrated a close link between maternal nutrition and chronic metabolic disease, suggesting epigenetic mechanisms that could affect the way we face this problem in the future. In such context, is of great importance to fully understand the mechanisms that control expression of the genes involved. In this work we will focus on the role of RNA as a key regulatory element in the control of gene expression in metabolic disorders.</p>}},
author = {{Verma, Gaurav and González-Rico, Susana}},
booktitle = {{RNA-Based Regulation in Human Health and Disease}},
isbn = {{9780128171936}},
keywords = {{Adipogenesis; Epigenetics; Gene regulation; LncRNA; Metabolic syndrome; MiRNA; PiRNA; RNA; SiRNA; Transcriptional control}},
language = {{eng}},
pages = {{175--199}},
publisher = {{ScienceDirect, Elsevier}},
title = {{RNA and metabolic disorders}},
url = {{http://dx.doi.org/10.1016/B978-0-12-817193-6.00008-X}},
doi = {{10.1016/B978-0-12-817193-6.00008-X}},
year = {{2020}},
}